期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 32, 期 1, 页码 99-105出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2016.1238362
关键词
Pyrazolo[4,3-e][1,2,4] triazine; sulfonamides; tyrosinase inhibitors; urease inhibitors
资金
- National Science Centre, Poland [10.13039/501100004281, NN405 092340]
A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4] triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their tyrosinase and urease inhibitory activity. Evaluation of prepared derivatives demonstrated that compounds (8b) and (8j) are most potent mushroom tyrosinase inhibitors whereas all of the obtained compounds showed higher urease inhibitory activity than the standard thiourea. The compounds (8a), (8f) and (8i) exhibited excellent enzyme inhibitory activity with IC50 0.037, 0.044 and 0.042 mu M, respectively, while IC50 of thiourea is 20.9 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据