4.6 Article

mRNA vaccines induce rapid antibody responses in mice

期刊

NPJ VACCINES
卷 7, 期 1, 页码 -

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41541-022-00511-y

关键词

-

资金

  1. National Institute of Health [AI124377, AI128751, AI126603, CA260476]
  2. CureVac
  3. Ragon Institute of MGH, MIT, and Harvard

向作者/读者索取更多资源

mRNA vaccines can be developed and produced quickly, and clinical trials have shown that they can rapidly induce antibody responses. Compared to other vaccine modalities, mRNA vaccines can elicit protective antibodies more quickly and stimulate rapid humoral immune responses, which is a unique and advantageous property for controlling infectious disease outbreaks.
mRNA vaccines can be developed and produced quickly, making them prime candidates for immediate outbreak responses. Furthermore, clinical trials have demonstrated rapid protection following mRNA vaccination. Thus, we sought to investigate how quickly mRNA vaccines elicit antibody responses compared to other vaccine modalities. We first compared the immune kinetics of mRNA and DNA vaccines expressing SARS-CoV-2 spike in mice. We observed rapid induction of antigen-specific binding and neutralizing antibodies by day 5 following mRNA (4 mu g/mouse), but not DNA (50 mu g/mouse), immunization. Comparing innate responses hours post immunization, the mRNA vaccine induced increased levels of IL-5, IL-6, and MCP-1 cytokines which maybe promoting humoral responses downstream. We then evaluated the immune kinetics of an HIV-1 mRNA vaccine in comparison to DNA, protein, and rhesus adenovirus 52 (RhAd52) vaccines of the same HIV-1 envelope antigen in mice. Again, induction of envelope-specific antibodies was observed by day 5 following mRNA vaccination, whereas antibodies were detected by day 7-14 following DNA, protein, and RhAd52 vaccination. Thus, eliciting rapid humoral immunity may be a unique and advantageous property of mRNA vaccines for controlling infectious disease outbreaks.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据