Nucleocapsid Antigenemia in Patients Receiving Anti-CD20 Therapy With Protracted COVID-19

Article Medical Laboratory Technology

Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection

Yu Zhang et al.

Summary: Serum nucleocapsid protein of SARS-CoV-2 is a biomarker for acute infection with high diagnostic sensitivity and specificity, which correlates to disease severity and inversely relates to antibody levels.

CLINICAL CHEMISTRY (2022)

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Editorial Material Medical Laboratory Technology

The Truth about SARS-CoV-2 Cycle Threshold Values Is Rarely Pure and Never Simple

Daniel D. Rhoads et al.

CLINICAL CHEMISTRY (2022)

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Article Immunology

Incidence, Clinical Presentation, Relapses and Outcome of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Patients Treated With Anti-CD20 Monoclonal Antibodies

Jorge Calderon-Parra et al.

Summary: A retrospective cohort study of 422 patients under anti-CD20 treatment found that patients infected with COVID-19 within 6 months post-treatment had higher rates of hospital admission, mortality, and relapse, as well as longer infectivity of the virus.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Biochemical Research Methods

Detection of SARS-CoV-2 nucleocapsid antigen from serum can aid in timing of COVID-19 infection

M. J. Ahava et al.

Summary: This study aimed to characterize the specificity and sensitivity of an enzyme-linked immunosorbent assay for the detection of SARS-CoV-2 nucleocapsid antigen in serum, and to describe the kinetics of antigenemia. The results showed high specificity and sensitivity of the test, providing accurate diagnosis of acute COVID-19.

JOURNAL OF VIROLOGICAL METHODS (2022)

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Article Multidisciplinary Sciences

Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients

Rosa Costa et al.

Summary: A combined kinetic analysis was conducted on 71 critically ill COVID-19 patients to study plasma RNAemia, N-antigenemia, and virus-specific antibodies. The study found a correlation between viral components and viral load in the upper respiratory tract, and observed a parallel decrease in antibody levels with increasing RNAemia and N-antigenemia levels.

SCIENTIFIC REPORTS (2022)

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Article Immunology

Nucleocapsid Antigenemia Is a Marker of Acute SARS-CoV-2 Infection

Hans P. Verkerke et al.

Summary: In this study, we evaluated SARS-CoV-2 nucleocapsid antigenemia as a marker of acute COVID-19 and investigated outliers to gain a better understanding of the phenomenon. The findings suggest that antigenemia can serve as a biomarker for acute SARS-CoV-2 infection and may have diagnostic utility in various contexts.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Immunology

Natural History of Coronavirus Disease 2019: Risk Factors for Hospitalizations and Deaths Among >26 Million US Medicare Beneficiaries

Hector S. Izurieta et al.

Summary: This study found that frailty, comorbid conditions, and race/ethnicity are significant risk factors for COVID-19 hospitalization and death among elderly individuals in the United States.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

Improving the Outcomes of Immunocompromised Patients With Coronavirus Disease 2019

Ghady Haidar et al.

Summary: Recent case studies have shown that immunocompromised individuals are at risk for prolonged SARS-CoV-2 replication, viral evolution, and poor clinical outcomes. The immunologic determinants of this risk, optimal treatment strategies, and use of immunosuppressive medications for COVID-19 in immunocompromised hosts are not well understood. Studies are needed to better understand these factors and improve management of these patients.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Dandan Shan et al.

Summary: The study introduces a highly sensitive Simoa immunoassay for detecting SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva, showing good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.

NATURE COMMUNICATIONS (2021)

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Review Microbiology

Can Testing Predict SARS-CoV-2 Infectivity? The Potential for Certain Methods To Be Surrogates for Replication-Competent Virus

Matthew J. Binnicker

Summary: The importance of molecular methods in diagnosing the disease during the COVID-19 pandemic is discussed, highlighting that molecular tests can continue to detect viral RNA. The challenges of current molecular diagnostic assays in differentiating infectious and noninfectious viral RNA are also addressed.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Editorial Material Medicine, General & Internal