期刊
DIABETES & METABOLISM JOURNAL
卷 46, 期 4, 页码 658-662出版社
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2021.0232
关键词
Diabetes mellitus; type 2; Glucagon-like peptide-1 receptor; Sodium-glucose transporter 2 inhibitors
In Korea, the combination of SGLT2i and GLP-1RA has been shown to significantly lower blood sugar levels in patients with type 2 diabetes, with good tolerability and safety.
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are novel anti -dia-betic drugs whose glucose-lowering effect and cardiovascular and renal benefits were evidenced in clinical trials. We investigated the real-world efficacy and safety of the combination of SGLT2i and GLP-1RA in patients with type 2 diabetes mellitus in Korea. The medical records of 104 patients who maintained the combination for at least 1 year were retrospectively reviewed. The change in glycosylated hemoglobin (HbA1c) after 6 months and 1 year of treatment was evaluated. The mean age was 51 years, and 41% were female. The mean baseline HbA1c, body mass index, and duration of diabetes were 9.0%, 28.8 kg/m2 , and 11.7 years, respec-tively. Compared with baseline, the HbA1c decreased by 1.5% (95% confidence interval [CI], 1.27 to 1.74; P<0.001) after 6 months and by 1.4% (95% CI, 1.19 to 1.70; P< 0.001) after 1 year. Over 1 year, the bodyweight change was -2.8 kg (95% CI, -4.21 to -1.47; P< 0.001). The combination of SGLT2i and GLP-1RA is effective and tolerable in type 2 diabetes mellitus patients in real -world practice.
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