☆ 4.7 Article

PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression

PHARMACEUTICS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Effects of 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone from Syzygium nervosum Seeds on Antiproliferative, DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Cervical Cancer Cell Lines

Kraikrit Utama et al.

Summary: This study investigated the inhibitory effects of the natural product 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) derived from Syzygium nervosum A. Cunn. ex DC. on various cancer cell lines, particularly cervical cancer. DMC displayed significant antiproliferative activity in different cervical cancer cell lines and induced DNA damage, cell cycle arrest, and apoptosis. The findings suggest that DMC has the potential to be developed as a therapeutic agent for antiproliferative cervical cancer treatment.

MOLECULES (2022)

添加到收藏夹

Article Agronomy

Combination Effects of Polyphenols Present in Sugarcane on Proliferation in MCF-7 Human Breast Cancer Cells

Yujiao Yang et al.

Summary: Sugarcane is rich in polyphenols, including quercetin, apigenin, luteolin, tricin, and p-coumaric acid, which have shown inhibitory effects against MCF-7 breast cancer cells. The combination of luteolin and p-coumaric acid exhibited synergistic effects at all tested concentrations, while luteolin combined with apigenin showed synergistic effects at high inhibition rates. synergistic relation among polyphenols present in sugarcane in inhibition of cancer cell growth.

SUGAR TECH (2022)

添加到收藏夹

Article Chemistry, Applied

Phytochemical constituents and in vitro anticancer screening of isolated compounds from Eriocephalus africanus‡

Judie Magura et al.

Summary: The study isolated hesperidin, luteolin, and apigenin from the methanolic extract of Eriocephalus africanus for the first time and found that these flavonoids exhibited dose-dependent cytotoxicity against various cancer cell lines. Hesperidin and luteolin were more effective against MCF-7 cells, while apigenin showed the highest cytotoxic activity against HepG2 cells. This suggests that E. africanus could be a potential source of natural anticancer agents for the development of new therapeutics.

NATURAL PRODUCT RESEARCH (2021)

添加到收藏夹

Article Biology

Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TOR/PI3K/AKT signalling pathway

Weiwei Kuang et al.

Summary: The study found that the phytoestrogen coumestrol has significant toxicity against human skin cancer cells, inducing cell cytotoxicity through apoptosis stimulation. Coumestrol also inhibits cell migration and invasion in skin cancer cells while blocking the m-TOR/PI3K/AKT signaling pathway.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Zhejie Chen et al.

Summary: Polyphenols, as naturally occurring bioactive products, have shown great potential in medical intervention of various diseases due to their special molecular structure. They play a multifaceted role in novel drug delivery systems, acting both as therapeutic agents and essential components of drug carriers. However, the active biochemical characteristics of polyphenols pose challenges for their high-frequency use in drug delivery systems.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel quercetin encapsulated chitosan functionalized copper oxide nanoparticles as anti-breast cancer agent via regulating p53 in rat model

Awny M. Elsayed et al.

Summary: This study introduced a new CuO-ChNPs-Q nanoparticle with potential anti-breast cancer activity, with in vitro results showing greater anticancer effects compared to CuONPs and quercetin, and in vivo experiments demonstrating a significant reduction in breast tumors with CuO-ChNPs-Q treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science

Tarun Sahu et al.

Summary: Nanotechnology, particularly in the field of nanomedicine, has been recognized as a key technology for improving healthcare strategies, especially in drug delivery. Living cells play crucial roles in biological activities, and nanotechnology has been widely utilized in the medical industry with significant potential for future developments in human health.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

添加到收藏夹

Editorial Material Urology & Nephrology

Management of chemotherapy side effects and their long-term sequelae

Isabella M. Zraik et al.

Summary: Various chemotherapy regimens are used to treat testicular cancer, which may lead to acute and late toxicities with general and special side effects. Long-term consequences like hypogonadism, infertility, or the metabolic syndrome should be carefully managed in young male patients.

UROLOGE (2021)

添加到收藏夹

Article Oncology

Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells

Yukyung Hong et al.

Summary: The study suggests that pro-NAG-1 could be a useful biomarker for thyroid cancer and quercetin might be a potential therapeutic target for treating thyroid cancer. The findings indicate that quercetin induced apoptosis by selectively inducing pro-NAG-1 expression, and not mature NAG-1, in thyroid cancer cells. Additionally, the study highlights the importance of identifying novel biomarkers for the diagnosis and treatment of thyroid cancer.

CANCERS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Nanotechnology and its use in imaging and drug delivery (Review)

Serjay Sim et al.

Summary: Nanotechnology exploits the unique properties of materials at the nanoscale, and has gained popularity in various industries. Nanomedicine, the application of nanotechnology in medicine and healthcare, has been used to combat common diseases with recent advances in imaging and drug delivery.

BIOMEDICAL REPORTS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Impact of nanosizing on dermal delivery and antioxidant activity of quercetin nanocrystals

Maria Letizia Manca et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling

Danhong Peng et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats

Yoo-Kyung Song et al.

PHARMACEUTICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Essential Oil ofCymbopogon citratusStapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-anthracene (DMBA)-Induced Breast Cancer in Female Rats

Juan Pedro Rojas-Armas et al.

MOLECULES (2020)

添加到收藏夹

Article Immunology

Activation of the executioner caspases-3 and-7 promotes microglial pyroptosis in models of multiple sclerosis

Brienne A. McKenzie et al.

JOURNAL OF NEUROINFLAMMATION (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Enhancing Curcumin Oral Bioavailability Through Nanoformulations

Vinod S. Ipar et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2019)

添加到收藏夹

Article Medicine, General & Internal

Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells

Firoozeh Niazvand et al.

MEDICINA-LITHUANIA (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells

Madhumitha Kedhari Sundaram et al.

BIOSCIENCE REPORTS (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Fei Tong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles

Kaili. Hu et al.

ACS NANO (2017)

添加到收藏夹

Article Food Science & Technology

Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice

Masuko Kobori et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

添加到收藏夹

Article Medicine, Research & Experimental

The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression

Cheng-lin Luo et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

Miao Lou et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

添加到收藏夹

Review Oncology

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

Mark A. Feitelson et al.

SEMINARS IN CANCER BIOLOGY (2015)

添加到收藏夹

Article Cell Biology

Photosensitized mefloquine induces ROS-mediated DNA damage and apoptosis in keratinocytes under ambient UVB and sunlight exposure

Neera Yadav et al.

CELL BIOLOGY AND TOXICOLOGY (2014)

添加到收藏夹

Article Toxicology

Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO2) nanoparticles

Sijing Xiong et al.

ARCHIVES OF TOXICOLOGY (2013)

添加到收藏夹

Article Oncology

Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells

Haesung Kim et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biodegradable polymeric micelle-encapsulated quercetin suppresses tumor growth and metastasis in both transgenic zebrafish and mouse models

Qinjie Wu et al.

NANOSCALE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ambient UVA-Induced Expression of p53 and Apoptosis in Human Skin Melanoma A375 Cell Line by Quinine

Neera Yadav et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2013)

添加到收藏夹

Article Neurosciences

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Genevieve Bureau et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A simple technique for quantifying apoptosis in 96-well plates

D Ribble et al.

BMC BIOTECHNOLOGY (2005)

添加到收藏夹

Article Biochemical Research Methods

Efficacy of MitoTracker Green™ and CMXRosamine to measure changes in mitochondrial membrane potentials in living cells and tissues

W Pendergrass et al.

CYTOMETRY PART A (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.