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Nanomedicines for Overcoming Cancer Drug Resistance

PHARMACEUTICS (2022)

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Review Oncology

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

Zhaowu Ma et al.

Summary: Rapid progress in molecular cancer biology and the discovery of new oncology drugs have opened new opportunities for cancer target discovery. HIF-1, a crucial signaling pathway related to tumorigenesis, regulates the activity of many transcription factors and downstream molecules that affect tumor growth and metastasis. Overexpression of HIF-1 alpha is strongly associated with poor prognosis in several solid cancers. Pharmacological targeting of the HIF-1 signaling pathway has been considered a new strategy for cancer therapy, but translation into clinically available treatments remains challenging.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Nanoscience & Nanotechnology

Self-Rectifiable and Hypoxia-Assisted Chemo-Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

Yanan Wang et al.

Summary: This study developed a hypoxia-assisted nanoinhibitor for enhanced photodynamic therapy and prevention of tumor metastasis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses

Yanjun Yang et al.

Summary: This study presents a red light-responsive self-destructive carrier for chemo-photodynamic therapy. The carrier achieves dual drug release and degradation of the organosilica matrix upon low-dose red light irradiation, resulting in a synergistic chemo-photodynamic effect. Furthermore, this therapy boosts immunogenic cell death and robust anti-tumor immunity responses.

BIOMATERIALS (2022)

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Article Biochemistry & Molecular Biology

DNA damage response proteins synergistically affect the cancer prognosis and resistance

Meetal Sharma et al.

Summary: Utilizing big data and system biology, this study identified system-level interactions between DNA damage response proteins in cancer cells under oxidative stress, shedding light on the mechanisms causing resistance. The findings suggest the importance of targeting disease-causing networks in combating resistance in cancer research.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Nanoscience & Nanotechnology

Hybrid Membrane Nanovaccines Combined with Immune Checkpoint Blockade to Enhance Cancer Immunotherapy

Peiqi Zhao et al.

Summary: The hybrid membrane nanovaccine combined with immune checkpoint blockade is a powerful strategy for enhancing antitumor immunotherapy by inhibiting tumor growth, eliminating established tumors, and rejecting re-challenged tumors through regulating the immunosuppressive microenvironment and immunological memory effect.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Medicinal

Targeting Regulated Cell Death with Pharmacological Small Molecules: An Update on Autophagy-Dependent Cell Death, Ferroptosis, and Necroptosis in Cancer

Junhao Wu et al.

Summary: Regulated cell death is an important topic in cancer therapy and has led to the discovery of targeted anticancer drugs. Nonapoptotic regulated cell death has been found to be involved in the therapeutic responses of various human cancers. Targeting autophagy-dependent cell death, ferroptosis, and necroptosis can bypass apoptosis resistance and improve cancer treatment.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Nanoscience & Nanotechnology

Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer

Jitu Halder et al.

Summary: Multidrug resistance (MDR) is a growing concern in cancer chemotherapy, with P-glycoprotein (P-gp) overexpression being one of the major reasons. Nanotechnology-based drug delivery systems offer opportunities to overcome MDR by bypassing or inhibiting the P-gp efflux pump.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Article Chemistry, Applied

A new liposomal nanocarrier for co-delivery of gedunin and p-glycoprotein siRNA to target breast cancer stem cells

Mohan Singh Rana et al.

Summary: A new liposomal nanocarrier, Lipo-Ged-siRNA, was developed to co-deliver gedunin and P-glycoprotein siRNA, aiming to improve the anti-proliferative activity of gedunin. Lipo-Ged-siRNA demonstrated stronger anti-proliferative effects and reduced expression of P-gp, as well as affecting the expression of multiple genes in bCSCs.

NATURAL PRODUCT RESEARCH (2022)

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Article Medicine, Research & Experimental

Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy

Guidong Gong et al.

Summary: In this study, a self-assembled nanomicelle with rationally designed building blocks is described, which shows a high efficiency of synergistic chemo-photodynamic therapy in an animal model. The nanomicelle possesses a low hemolysis rate, prolonged blood circulation time, and significantly improved antitumor efficacy.

THERANOSTICS (2022)

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Article Biotechnology & Applied Microbiology

Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer

Longxia Li et al.

Summary: This study investigated the combined application of miR497 and TP in overcoming cisplatin-resistant ovarian cancer (OC) by suppressing the mTOR signaling pathway. Bioinspired hybrid nanoparticles were prepared to deliver miR497 and TP, showing efficient uptake by tumor cells and significant anticancer activity in vitro and in vivo. Mechanistically, the nanoparticles promoted dephosphorylation of the overactivated PI3K/AKT/mTOR signaling pathway and enhanced reactive oxygen species (ROS) generation and macrophage polarization. Overall, this study offers a translational strategy to overcome cisplatin-resistant OC and potentially treat other cisplatin-resistant tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer

Chengyuan Zhang et al.

Summary: Multidrug resistance (MDR) is a major reason for chemotherapy failure, and developing nano-delivery systems for MDR tumors has become important. This review systematically summarizes recent advances in nanotechnology targeting different mechanisms of MDR. However, there are still issues with nano-delivery systems for MDR tumors, such as excessive use of carrier materials, low drug-loading capacity, and limited targeting mechanisms.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Nanoscience & Nanotechnology

Multifunctional Human Serum Albumin Fusion Protein as a Docetaxel Nanocarrier for Chemo-photothermal Synergetic Therapy of Ovarian Cancer

Yiting Shen et al.

Summary: This study developed a recombinant protein integrating His, HSA, enzyme responsive site, and RGD to co-load DTX and Au NPs for cancer therapy. The RHMH18@AuD NPs exhibited favorable biocompatibility and positive chemo-photothermal synergetic therapy efficiency in in vitro and in vivo experiments.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Pharmacology & Pharmacy

RNAi-based therapeutics and tumor targeted delivery in cancer

Goknur Kara et al.

Summary: Over the past decade, non-coding RNA-based therapeutics have shown great potential for targeted therapies in cancer and other diseases. miRNA and siRNA, through RNA interference, have been successful in inhibiting cancer-related genes with high specificity. Nanodelivery strategies play a crucial role in the success of miRNA and siRNA therapeutics, improving targeting and reducing side effects.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Biochemistry & Molecular Biology

The paradigm of drug resistance in cancer: an epigenetic perspective

Swagata Adhikari et al.

Summary: This article reviews the challenges in cancer treatment due to innate and acquired resistance, with a focus on the role of cancer stem cells (CSCs) in therapy resistance. The article discusses in detail the epigenetic alterations associated with drug resistance and the interaction between cancer cells and the microenvironment. Additionally, alternative treatment strategies and epigenome-modifying therapies that show potential in overcoming drug resistance are provided.

BIOSCIENCE REPORTS (2022)

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Review Oncology

Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs

Gerard Milano et al.

Summary: Irinotecan is a topoisomerase inhibitor commonly used in pancreatic cancer treatment. Liposomal irinotecan has demonstrated enhanced efficacy and tolerability in treating metastatic PDAC.

CANCER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Recent Advances of Nanotechnology in the Treatment of Skin Cancer

Abhishek Kanugo

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Targeting metabolism to overcome cancer drug resistance: A promising therapeutic strategy for diffuse large B cell lymphoma

Manfei Pi et al.

Summary: Cancer cell metabolism plays a crucial role in cancer progression and drug resistance. Various signal transduction pathways regulate tumor metabolism, and targeting these pathways could be a promising therapeutic strategy for cancer treatment.

DRUG RESISTANCE UPDATES (2022)

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Article Chemistry, Medicinal

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel

Wei Shi et al.

Summary: Chemotherapy is a crucial treatment for cancer, but resistance can occur. Researchers developed and synthesized compounds with dual inhibition to overcome resistance and improve the bioavailability of oral chemotherapy drugs.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Medicinal

Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment

Zhenwei Zhang et al.

Summary: This review focuses on recent advances in the discovery of novel apoptosis inducers targeting Bcl-2 anti-apoptotic proteins, aiming to overcome existing therapeutic limitations, and introduces strategies and advanced technologies in drug design and optimization.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Cell Biology

Resistance to immunotherapy in human malignancies: Mechanisms, research progresses, challenges, and opportunities

Davood Bashash et al.

Summary: Despite advances in cancer therapies, effective treatment remains a challenge due to cancer cells' mechanisms for survival. Immunotherapy shows promise, but response rates vary by cancer type, highlighting the need to understand resistance mechanisms and develop strategies to overcome them. Ongoing research aims to improve outcomes for cancer patients undergoing immunotherapy.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Chemistry, Physical

Nanoarchitectonics with metal-organic frameworks and platinum nanozymes with improved oxygen evolution for enhanced sonodynamic/chemo-therapy

Qian Ren et al.

Summary: Sonodynamic therapy (SDT) holds great potential in cancer treatment, but faces limitations. This study addresses the limitations by preparing a nanoarchitectonics based on metal-organic frameworks (MOFs) containing platinum (Pt) nanozymes. The results demonstrate that the nanoplatform effectively alleviates tumor hypoxia and enhances the sensitivity of SDT and chemotherapy, leading to remarkable inhibition of tumor growth.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Recent updates on innovative approaches to overcome drug resistance for better outcomes in cancer

Madhu Sharma et al.

Summary: Drug resistance is a significant hindrance in cancer chemotherapy, and this article systematically presents the main aspects of drug resistance and general approaches to reduce it. Recent advancements in developing new therapeutic innovations to combat drug resistance in the tumor microenvironment are highlighted.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Oncology

Resistance to immune checkpoint blockade: Mechanisms, counter-acting approaches, and future directions

Alexander F. Haddad et al.

Summary: Immunotherapies, especially immune checkpoint blockade, have shown promise in treating cancer by unleashing the immune system against cancer cells. However, the efficacy varies across cancer types and some patients do not respond to these therapies. Understanding the underlying mechanisms of resistance is crucial for predicting response and tailoring personalized treatment paradigms.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Cell & Tissue Engineering

Immune evader cancer stem cells direct the perspective approaches to cancer immunotherapy

Hassan Dianat-Moghadam et al.

Summary: Exploration of tumor immunity has led to the development of immune checkpoint inhibitors and cell-based immunotherapies, improving clinical outcomes for certain tumor types. However, the complex tumor microenvironment, cellular heterogeneity, and cancer stem cells contribute to poor clinical efficacy in other tumors. Understanding the immune features of cancer stem cells could lead to therapeutic targets for effective anti-tumor responses.

STEM CELL RESEARCH & THERAPY (2022)

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Review Cell & Tissue Engineering

Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells

Hamed Rezayatmand et al.

Summary: Drug resistance caused by cancer stem cells (CSCs) is the main reason for the failure and relapse of cancer therapy. CSCs possess the ability to self-renew and differentiate into heterogeneous cancer cells, and play a significant role in metastatic dissemination. Although chemotherapy can destroy most tumor cells, CSCs are left mostly intact, leading to resistance to treatment. It is crucial to understand the key features of drug resistance caused by CSCs in order to develop effective treatment strategies, but there are challenges in differentiating CSCs from normal cells.

STEM CELL RESEARCH & THERAPY (2022)

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Review Immunology

Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Mubin Tarannum et al.

Summary: This article summarizes the key challenges and innovative strategies in the clinical application of natural killer cell research.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Actively Targeted Nanomedicines in Breast Cancer: From Pre-Clinal Investigation to Clinic

Ana Isabel Fraguas-Sanchez et al.

Summary: Despite limitations of conventional chemotherapy, active targeted nanomedicine, especially antibody-drug conjugates, show promise in improving the treatment of breast cancer by selectively delivering antineoplastic drugs to tumor cells. Several nanomedicines have been approved or investigated for breast cancer treatment, targeting specific receptors and incorporating different drugs. These nanomedicines can reduce toxicity and improve treatment efficacy.

CANCERS (2022)

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Review Oncology

Dual-Targeted Therapy Circumvents Non-Genetic Drug Resistance to Targeted Therapy

Wei Wang et al.

Summary: The introduction of targeted agents has revolutionized cancer treatment, but drug resistance remains a challenge. This review article discusses the mechanisms of non-genetic resistance and the theoretical basis for overcoming it.

FRONTIERS IN ONCOLOGY (2022)

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Review Pharmacology & Pharmacy

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Deepak Kulkarni et al.

Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy

Tian Zhang et al.

Summary: Immunotherapy based on immune checkpoint inhibitors has become a crucial approach in cancer treatment, but overcoming treatment resistance is a major challenge. The tumor microenvironment (TME) plays a significant role in the pathological behaviors and treatment responses of cancers. This review summarizes five main biophysical cues in the TME that impact immunotherapy resistance and discusses the latest treatment strategies targeting these cues to improve immunotherapy efficacy.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Biochemistry & Molecular Biology

HIF-1-dependent heme synthesis promotes gemcitabine resistance in human non-small cell lung cancers via enhanced ABCB6 expression

Lisha Xiang et al.

Summary: This study found that the expression of ABCB6 in human NSCLCs is associated with poor prognosis and gemcitabine resistance. Activation of HIF-1 alpha/ABCB6 signaling leads to increased catalase levels, reducing the effective levels of reactive oxygen species and promoting gemcitabine resistance. Inhibition of HIF-1 alpha or ABCB6, in combination with gemcitabine, effectively restrains tumor proliferation, increases tumor cell apoptosis, and prolongs animal survival.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Biophysics

Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer

Qingran Guan et al.

Summary: Novel laser-responsive multi-functional nanoparticles (NPs-Lip@PTX/CyA/Ce6) were developed using bovine serum albumins (BSA) as the base material, simultaneously carrying chemotherapeutic drug paclitaxel (PTX) and P-gp inhibitor cyclosporin A (CyA) as the core, and Tf-modified liposomal bilayer loaded with photosensitizer Chlorin e6 (Ce6) as the shell. The NPs-Lip@PTX/CyA/Ce6 exhibited a core-shell structure with good stability in aqueous solution. Upon laser irradiation, the NPs-Lip@PTX/CyA/Ce6 showed laser-responsive release profiles, enabling efficient combinatorial chemophotodynamic therapy and reversal of drug resistance. The NPs-Lip@PTX/CyA/Ce6 demonstrated excellent intracellular ROS productivity and anti-cancer therapy effect without systemic toxicity. In conclusion, this nano-drug delivery system holds promise for clinical applications in compositional chemophotodynamic therapy synergistically.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Biochemistry & Molecular Biology

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial

Lacey J. Padron et al.

Summary: Chemotherapy combined with immunotherapy has improved the treatment of certain solid tumors, however, finding effective regimens for pancreatic ductal adenocarcinoma (PDAC) remains a challenge. A randomized phase 2 trial evaluated the efficacy of nivolumab and sotigalimab with chemotherapy in metastatic PDAC patients. The primary endpoint of 1-year overall survival was met for nivo/chemo but not for sotiga/chemo or sotiga/nivo/chemo. Biomarker analyses identified immune signatures associated with survival for different treatment groups.

NATURE MEDICINE (2022)

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Article Engineering, Biomedical

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

Lifo Ruan et al.

Summary: The use of mitochondrial temperature-responsive drug delivery system can prevent drug efflux, facilitate drug accumulation and mitochondrial targeting in drug-resistant tumors. This technology enhances drug toxicity and reverses drug resistance, representing a significant advancement in combating cancer drug resistance.

BIOACTIVE MATERIALS (2022)

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Review Medicine, Research & Experimental

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Fei Qu et al.

Summary: Skin diseases have a significant impact on patients' quality of life and the global economy. Advanced transdermal drug delivery strategies, such as nanocarrier and microneedle-based systems, offer efficient and targeted drug delivery with reduced side effects and improved functions.

THERANOSTICS (2022)

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Article Medicine, Research & Experimental

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Shouhui Yi et al.

Summary: Combination therapy offers advantages for cancer treatment, but different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo, leading to uncontrollable concentration ratio of therapeutic agents. Multifunctional co-delivery systems can provide targeted delivery and controlled release in response to tumor microenvironment, resulting in better synergistic anticancer effect and potential clinical applications.

THERANOSTICS (2022)

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Review Immunology

Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy

Jii Bum Lee et al.

Summary: Targeting immune evasion through immune checkpoint pathways has revolutionized cancer treatment. This review discusses the historical discovery of CTLA-4 and PD-1 and their potential as anti-cancer therapeutics. It also explores the clinical utility of immune checkpoint inhibitors, particularly in non-small cell lung cancer, and the ongoing research on combination therapy and novel ICIs.

IMMUNE NETWORK (2022)

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Article Oncology

Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models

Sun Min Lim et al.

Summary: In this study, the genetic profiles of osimertinib-resistant NSCLC patient samples were explored using targeted deep sequencing. In vitro and in vivo models with osimertinib resistance revealed potential novel treatment strategies after osimertinib failure.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy

Lulu Li et al.

Summary: The DNA damage response pathway is complex and defects in subordinate pathways can lead to cancer susceptibility. Developing small molecule inhibitors targeting chief proteins in the DDR pathway is crucial for cancer therapy. The action mode of DDR molecule inhibitors in preclinical and clinical cancer therapy, including combination therapy with chemotherapeutic drugs or checkpoint suppression therapy, is significant for cancer treatment.

CURRENT MEDICINAL CHEMISTRY (2021)

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Review Instruments & Instrumentation

Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy

Vahid Alimardani et al.

Summary: Microneedles arrays (MNs) have been introduced as a novel, minimally invasive, and low-cost approach to deliver drugs to tumor tissues in a safe and controlled manner. They have promising potential in cancer therapy applications.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Chemistry, Medicinal

Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp)

Hang Zhang et al.

Summary: This review highlights the recent achievements in drug design and mechanism studies of newly synthetic P-gp inhibitors in the past 5 years, which will help overcome multidrug resistance in cancer chemotherapy.

MEDICINAL RESEARCH REVIEWS (2021)

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Review Engineering, Biomedical

Progress and perspective of microneedle system for anti-cancer drug delivery

Dongdong Li et al.

Summary: Transdermal drug delivery is promising, especially through superficial routes. Microneedles can overcome limitations and deliver drugs into the dermal layer efficiently. They have been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy.

BIOMATERIALS (2021)

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Review Oncology

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Asieh Emami Nejad et al.

Summary: Tumor hypoxia, caused by rapid tumor growth and abnormal blood vessel formation, can activate angiogenesis, increase tumor survival, suppress immunity, and requires management through mechanisms such as altering gene expression. The potential use of cancer stem cells in tumor treatment has been highlighted.

CANCER CELL INTERNATIONAL (2021)

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Article Engineering, Biomedical

Drug-eluting immune checkpoint blockade antibody-nanoparticle conjugate enhances locoregional and systemic combination cancer immunotherapy through T lymphocyte targeting

David M. Francis et al.

Summary: The development of an antibody-nanoparticle conjugate platform has shown promising results in enhancing the delivery of small molecule therapeutics to T lymphocytes, improving both local and systemic anti-tumor effects in cancer immunotherapy.

BIOMATERIALS (2021)

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Review Oncology

The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities

Mohammad-Javad Sanaei et al.

Summary: Immunosurveillance mechanisms and immune checkpoints play crucial roles in the development and treatment of cancer. Immune checkpoint blockades (ICBs) have the potential to enhance cancer treatment, especially when combined with nanoparticles for targeted drug delivery to tumor sites.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Article Chemistry, Applied

An intelligent hypoxia-relieving chitosan-based nanoplatform for enhanced targeted chemo-sonodynamic combination therapy on lung cancer

Peixia Zhang et al.

Summary: CEPH nanoplatform has the potential to enhance the efficacy of oxygen dependent SDT and overcome hypoxia-induced TMT resistance for improved synergistic TMT/SDT, by alleviating hypoxia, suppressing NSCLC cell growth, and enhancing the production of reactive oxygen species through ultrasound activation.

CARBOHYDRATE POLYMERS (2021)

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Review Oncology

Systemic Therapy for Lung Cancer Brain Metastases

Alessia Pellerino et al.

Summary: Systemic therapy for brain metastases is shifting towards targeted therapies, showing impressive results with tyrosine kinase inhibitors. However, resistance and early detection of tumor progression remain major issues in the development of effective new targeted agents. Emerging technologies such as liquid biopsy and radiomics play important roles in monitoring treatment efficacy.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Anticancer drug resistance: An update and perspective

Ruth Nussinov et al.

Summary: Driver mutations play a critical role in cancer initiation and progression, with drug resistance being a common challenge in pharmacological treatment. The emergence of drug resistance can be attributed to a variety of mechanisms, such as mutations occurring in the same or different proteins, and in the same or parallel pathways. The complexity of genetic alterations and tumor microenvironment changes poses challenges in predicting drug resistance and requires further research in precision medicine.

DRUG RESISTANCE UPDATES (2021)

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Article Pharmacology & Pharmacy

Co-delivery of gefitinib and hematoporphyrin by aptamer-modified fluorinated dendrimer for hypoxia alleviation and enhanced synergistic chemo-photodynamic therapy of NSCLC

Fangyin Zhu et al.

Summary: Researchers have synthesized a novel drug carrier APF and prepared nanocomplexes APFHG, which can effectively combat EGFR-TKIs resistance and synergistically treat EGFR mutation-positive NSCLC by co-delivering gefitinib and hematoporphyrin.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Cutaneous toxicity of FDA-approved small-molecule kinase inhibitors

Jiangxia Du et al.

Summary: Small-molecule kinase inhibitors can cause cutaneous toxicities which affect patients' emotional, physical, and psychological health. Future research should focus on the mechanisms of SMKI-induced cutaneous toxicities to discover mechanistically driven therapies.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)

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Article Nanoscience & Nanotechnology

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells

Shiyang Shen et al.

Summary: This study presents a nanoparticle-based strategy for killing CSCs in tumors by inducing CSC differentiation with all-trans retinoic acid release under hypoxic conditions and triggering cell death with camptothecin release in response to increasing reactive oxygen species levels in differentiating CSCs.

NATURE NANOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Hypoxia-responsive pullulan-based nanoparticles as erlotinib carriers

Hriday Bera et al.

Summary: A hypoxia-responsive pullulan-based co-polymer was developed to deliver erlotinib to cervical cancer cells and exhibited faster drug release profile under hypoxic condition.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

High expression of hypoxia inducible factor 1α related with acquired resistant to EGFR tyrosine kinase inhibitors in NSCLC

Qian Jin et al.

Summary: The study found that the expression of HIF-1 alpha in EGFR-TKIs sensitive NSCLC tissue was significantly higher, and the level of HIF-1 alpha increased further after acquiring resistance. There was a negative correlation between HIF-1 alpha level and the occurrence time of acquired resistance as well as the acquired EGFR T790M mutation.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

Active targeting strategy in nanomedicines using anti-EGFR ligands-A promising approach for cancer therapy and diagnosis

Phuoc Vinh Nguyen et al.

Summary: EGFR has emerged as a promising oncomarker for active targeting nanomedicines in cancer therapy. Many novel EGFR-targeted nanomedicines have shown encouraging results in both in vitro and in vivo studies. The review highlights the various applications of these medicines in oncology, emphasizing the contribution of EGFR-targeting ligands to therapy efficacy and addressing current challenges and potential solutions.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Thermo-Triggered In Situ Chitosan-Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection

Jialin She et al.

Summary: The thermo-triggered in situ hydrogel system enhances the efficacy of sonodynamic therapy by reversing the oxygen-deficient status in solid tumors, offering robust treatment effects to effectively eradicate tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

AZD9291 Resistance Reversal Activity of a pH-Sensitive Nanocarrier Dual-Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC

Yu Gu et al.

Summary: The study reveals activation of autophagy and FGFR1 signaling pathways in AZD9291 resistant NSCLC, and demonstrates that the pH-sensitive shell-core nanoparticles CP@NP-cRGD can effectively reverse resistance by inducing apoptosis, G0/G1 phase arrest, and downregulation of p-ERK1/2. The coloaded CQ and PD173074 nanoparticle has shown tumor targeting abilities, low toxicity and promising antitumor effects in mouse models, providing a potential novel approach for overcoming AZD9291 resistance in clinical settings.

ADVANCED SCIENCE (2021)

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Review Oncology

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

Jing Zhou et al.

Summary: The article discusses the resistance mechanisms to anti-EGFR monoclonal antibodies, as well as diverse approaches to reverse resistance to this therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Cell Biology

Drug resistance and Cancer stem cells

Yuan Li et al.

Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Chemistry, Multidisciplinary

Circumventing Drug Resistance Pathways with a Nanoparticle-Based Photodynamic Method

Yan Liu et al.

Summary: Drug resistance is a major obstacle in cancer therapy, but nanoparticle-based photodynamic therapy shows promise in overcoming this challenge. By targeting multiple resistant pathways and inducing cell apoptosis via downstream genes, this therapy may offer a new approach to combat drug resistance in cancer.

NANO LETTERS (2021)

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Article Biotechnology & Applied Microbiology

Tumor cell-secreted exosomal miR-22-3p inhibits transgelin and induces vascular abnormalization to promote tumor budding

Yaju Feng et al.

Summary: Tumor budding is considered a poor prognostic marker in breast cancer patients, and promoting tumor vessel normalization through regulating the structure and function of endothelial cells may help improve therapeutic efficacy.

MOLECULAR THERAPY (2021)

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Review Pharmacology & Pharmacy

DNA Repair Pathways in Cancer Therapy and Resistance

Lan-ya Li et al.

Summary: DNA repair pathways play a crucial role in maintaining genetic stability in mammalian cells exposed to DNA-damaging agents, and their deregulation is associated with cancer development. Targeting DNA repair pathways could be a potential therapeutic approach for enhancing the effectiveness of cancer treatments.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Zhuoran Gong et al.

Summary: Sonodynamic therapy (SDT) combines low-intensity ultrasound and sonosensitizers to treat deeper lesions, showing promise for clinical translation. The development of advanced equipment and smart nanomaterial-based sonosensitizers, as well as multidisciplinary collaboration, will promote the rapid development and clinical translation of SDT.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A Systematic Strategy of Combinational Blow for Overcoming Cascade Drug Resistance via NIR-Light-Triggered Hyperthermia

Lingna Wang et al.

Summary: A systematic combination strategy utilizing near-infrared light-triggered hyperthermia, combined with cisplatin, was proposed to overcome drug resistance. The strategy showed significant efficacy in inhibiting the growth of multidrug-resistant lung cancer in both in vitro and in vivo studies.

ADVANCED MATERIALS (2021)

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Review Engineering, Biomedical

Inorganic chemoreactive nanosonosensitzers with unique physiochemical properties and structural features for versatile sonodynamic nanotherapies

Caihong Dong et al.

Summary: The development of nanomedicine and nanobiotechnology has led to versatile therapeutic modalities like nanosonosensitizer-involved sonodynamic therapy (SDT), which uses ultrasound to induce the production of reactive oxygen species for disease therapy. Inorganic chemoreactive nanosonosensitizers, compared to organic ones, have higher stability and different mechanisms. Challenges include improving SDT efficiency and advancing clinical applications.

BIOMEDICAL MATERIALS (2021)

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Review Genetics & Heredity

The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?

Fatemeh Sadoughi et al.

Summary: DDR is a crucial mechanism in cancer therapy, as error-free DDR can lead to cancer cells escaping cell death and developing resistance to treatment. Targeting different components of DDR can increase the susceptibility of advanced tumors to chemo- and radio-therapy.

DNA REPAIR (2021)

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Review Cell Biology

Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer

Dylan A. Farnsworth et al.

Summary: Mutant EGFR is a molecular driver of non-small cell lung cancer, and tumors with these mutations often rely on sustained oncogene signaling. While inhibiting EGFR with tyrosine kinase inhibitors has shown clinical benefits, resistance remains a challenge. The genetic mechanisms underlying EGFR dependency and factors allowing tumor cells to escape this dependency are still not fully understood.

CELLS (2021)

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Review Oncology

HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies

Xin Wang et al.

Summary: Ovarian cancer is the eighth most commonly diagnosed cancer among women worldwide. HIF-1 alpha plays a crucial role in promoting malignant cell chemoresistance, tumour metastasis, angiogenesis, immunosuppression, and intercellular interactions in ovarian cancer, making it a potential therapeutic target.

FRONTIERS IN ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective

Yongquan Tang et al.

Summary: Cancer stem cells (CSCs) are cells with self-renewal and tumorigenic properties, playing crucial roles in tumor development and resistance to treatment. Targeting CSC signaling pathways is a promising therapeutic strategy, with advancements in cancer omics providing new targets. Nanotechnology for RNAi delivery can enhance efficacy by overcoming limitations of RNAi.

PHARMACEUTICS (2021)

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Review Biotechnology & Applied Microbiology

Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Lei Cao et al.

Summary: This article discussed various mechanisms of drug resistance and recent advances in nanotechnology-based therapeutic strategies, highlighting the potential and advantages of nanomaterials in overcoming drug resistance in tumor chemotherapy.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Kinase drug discovery 20 years after imatinib: progress and future directions

Philip Cohen et al.

Summary: Advances in improving the potency and specificity of small-molecule protein kinase inhibitors over the past 20 years have had a significant impact on the treatment of cancers and non-cancerous conditions. Efforts are being made to address the challenge of drug resistance to kinase inhibitors, and future directions in kinase drug discovery are being discussed.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Chemistry, Multidisciplinary

Synergistic Combination of Bioactive Hydroxyapatite Nanoparticles and the Chemotherapeutic Doxorubicin to Overcome Tumor Multidrug Resistance

Xiulin Dong et al.

Summary: This study demonstrates the potential of bioactive nanoparticles in overcoming multidrug resistance in cancer chemotherapy. By utilizing the synergistic effects of HAPNs and DOX, the efficacy of drug treatment for breast cancer was significantly improved, possibly due to the multiple action mechanisms of HAPNs.

SMALL (2021)

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Article Nanoscience & Nanotechnology

Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor

Chao Shi et al.

Summary: This study focused on enhancing therapeutic efficacy by encapsulating a mitochondria-anchored photosensitizer and a chemotherapy drug in liposomal nanomedicine, inducing mitochondrial dysfunction to overcome multidrug resistance. At a cellular level, the nanomedicine successfully implemented PDT to reduce drug efflux and increase drug uptake in drug-resistant cells, showing great potential in overcoming MDR tumors.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Reversing Chemotherapy Resistance by a Synergy between Lysosomal pH-Activated Mitochondrial Drug Delivery and Erlotinib-Mediated Drug Efflux Inhibition

Furong Cheng et al.

Summary: The study presents a lysosomal pH-activated mitochondrial-targeting polymer nanoparticle (DE-NPs) for overcoming drug resistance by delivering doxorubicin to mitochondria and inhibiting drug efflux through erlotinib. The nanoparticles undergo charge reversal at lysosomal pH, enhancing cellular escape and mitochondrial-targeted drug delivery, leading to a significant anticancer effect in drug-resistant cells. This work highlights the potential of combining mitochondrial drug delivery and drug efflux inhibition as a promising strategy for combating multidrug resistance.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer

Wu Chen et al.

Summary: This study developed nanoparticles to co-deliver osimertinib (OSI) and selumetinib (SEL) in order to effectively treat OSI-resistant non-small cell lung cancer. The nanoparticles, formed through a ROS-responsive PEG-SEL conjugate, demonstrated potential by inhibiting OSI-resistant tumors in vivo.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity

Idoia Mikelez-Alonso et al.

Summary: NK cells are lymphocytes with potent antitumor and antiviral functions, exhibiting memory-like responses. Various NK cell-based immunotherapies have been developed, with nanotechnology considered as an attractive option to enhance NK cell effector functions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Applied

Etherified pullulan-polyethylenimine based nanoscaffolds improved chemosensitivity of erlotinib on hypoxic cancer cells.

Hriday Bera et al.

Summary: The study aimed to develop a hypoxia-responsive polymer for delivering erlotinib to reverse drug resistance in cancer cells, showing rapid drug release and enhanced anti-tumor effects under hypoxic conditions.

CARBOHYDRATE POLYMERS (2021)

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Review Pharmacology & Pharmacy

Novel nanomedicines to overcome cancer multidrug resistance

Zhenwei Su et al.

Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.

DRUG RESISTANCE UPDATES (2021)

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Review Pharmacology & Pharmacy

Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function

Lingyue Gao et al.

Summary: Loss of function of tumor suppressor genes (TSGs) is a key factor in cancer drug resistance, and can be targeted through various mechanisms for therapeutic restoration of TSGs function, offering a novel strategy to overcome cancer drug resistance.

DRUG RESISTANCE UPDATES (2021)

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Review Chemistry, Medicinal

An update of new small-molecule anticancer drugs approved from 2015 to 2020

Xiaoxia Liang et al.

Summary: A high incidence of cancer has led to the development of fifty-six new small-molecule anticancer drugs from 2015 to 2020, categorized into ten groups based on their antitumor targets. Among these drugs, PTK inhibitors have played a key role in changing the paradigm of cancer treatment, with lower toxicity and higher potency.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Nanotechnology of Tyrosine Kinase Inhibitors in Cancer Therapy: A Perspective

Eleonora Russo et al.

Summary: Nanotechnology plays a crucial role in modern cancer therapy, improving drug penetration into tumor tissues, extending blood circulation times, reducing side effects, and minimizing drug accumulation in healthy tissues. Developing new nanoparticle systems for small molecule tyrosine kinase inhibitors is essential to enhance drug solubility and reduce toxicity, especially for first-line cancer therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Multidisciplinary

The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy

Shangui Liu et al.

Summary: Multidrug resistance is a persistent problem in cancer chemotherapy, but targeting the tumor microenvironment with multifunctional nanoparticles shows promise in overcoming this resistance.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Mitochondria-targeted vitamin E succinate delivery for reversal of multidrug resistance

Lina Liang et al.

Summary: The study demonstrated a successful strategy of utilizing vitamin E succinate within nanovesicles to target mitochondria and induce dysfunction, resulting in enhanced killing-effect of doxorubicin hydrochloride towards drug resistant cancer cells. This approach provides a safe and promising method for precise drug delivery and MDR eradication in cancer therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

Meng Yuan et al.

Summary: The study demonstrates that hemoglobin (Hb) as a sonosensitizer shows great potential and has better sensitization efficiency compared to traditional sonosensitizers, effectively avoiding the low ROS quantum yield problem. By integrating with ZIF-8 to form a nanoplatform, it can effectively suppress deep-seated tumors under ultrasound irradiation.

NANO LETTERS (2021)

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Review Biotechnology & Applied Microbiology

Trends in kinase drug discovery: targets, indications and inhibitor design

Misty M. Attwood et al.

Summary: The article analyzes the landscape of approved and investigational therapies that target kinases, highlighting the increasing importance of kinase inhibitors in oncology and beyond. It discusses trends in kinase inhibitor design and points out that there are still substantial unexplored opportunities for this drug class.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Cell Biology

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Yao-Xin Lin et al.

Summary: Clinical evidence suggests that restoration of functional PTEN through mRNA delivery by polymeric nanoparticles can effectively induce immune activation in tumor cells, reversing immunosuppressive tumor microenvironment and enhancing sensitivity to immune checkpoint blockade therapy. In vivo results show that PTEN mRNA nanoparticles promote CD8(+) T cell infiltration, increase proinflammatory cytokine expression, and decrease regulatory T cells and myeloid-derived suppressor cells, resulting in potent antitumor effects and immunological memory in cancer models.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Chemistry, Multidisciplinary

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Dong Li et al.

Summary: Sonodynamic therapy (SDT) is a novel noninvasive therapeutic approach that combines low-intensity ultrasound with sonosensitizers. Compared to phototherapy, SDT offers advantages such as deeper tissue penetration, high accuracy, and reduced side effects. The use of organic sonosensitizers is crucial for therapeutic efficacy, and nanotechnology holds potential for overcoming obstacles and fostering innovation in this field.

SMALL (2021)

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Article Biotechnology & Applied Microbiology

Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer

Peiqi Zhao et al.

Summary: This study developed a combined photothermal immunotherapy strategy using BBPQDs for TNBC treatment, showing enhanced antitumor activity compared to anti-PD-L1 monotherapy. The strategy effectively inhibits tumor recurrence and metastasis by reprogramming the tumor microenvironment and inducing immune memory against tumor rechallenge.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance

Khalil Khalaf et al.

Summary: The tumor microenvironment (TME) is a complex and dynamic tissue containing various components such as blood supply, immune cells, and extracellular matrix, which together create an environment conducive to tumor cell growth and proliferation. Cellular crosstalk, cell-to-ECM communication, exosomes, and specific metabolic patterns play crucial roles in immune evasion and therapy resistance in the TME. In addition, characteristics like hypoxia, metabolic abnormalities, and mechanical forces further contribute to treatment resistance.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

Immune Checkpoints in Cancers: From Signaling to the Clinic

Celine Pisibon et al.

Summary: Immune checkpoint therapies have revolutionized cancer treatment by reactivating the patient's immune system. Despite clear benefits observed in patients, many still fail to respond or develop resistance to these treatments. Understanding the mechanisms of immune checkpoints is essential for overcoming resistance and improving clinical outcomes.

CANCERS (2021)

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Review Oncology

An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor

Yukari Shirai et al.

Summary: HIF-1 is a critical target for cancer therapy due to its association with hypoxia, malignant phenotype, and therapy resistance in tumors. Recent research has focused on uncovering the molecular mechanisms of HIF-1 activation, identifying HIF-1 activators, and developing anticancer drugs targeting HIF-1.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

Li Chen et al.

Summary: Biomimetic nanoparticles (BNPs) integrate biological vectors with functional agents for targeted drug delivery. Natural vectors are deliberately modified to enhance permeability, loading capability, and specificity, making them more effective for delivering contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Medicine, Research & Experimental

Recent progress in nanomedicine for enhanced cancer chemotherapy

Guoqing Wei et al.

Summary: Nanomedicine has shown significant progress in improving cancer chemotherapy, including drug enrichment and tissue penetration, subcellular organelle-targeted chemotherapy, and reversal of multidrug resistance. The advantages of combination therapy in cancer treatment are emphasized.

THERANOSTICS (2021)

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Review Medicine, Research & Experimental

Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance

Xiao Wei et al.

Summary: The primary cause of chemotherapy failure is cancer multidrug resistance (MDR), leading to recurrence and metastasis of cancer. Dual-therapeutic combination using multifunctional nanoplatforms is gaining attention for overcoming resistant cancers. Smart co-delivery nanocarriers can improve drug properties, enhance therapeutic efficacy, and even overcome drug resistance.

THERANOSTICS (2021)

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Review Oncology

EGFR-mutant NSCLC: emerging novel drugs

Lingyun Ye et al.

Summary: Despite significant advances in EGFR-mutant NSCLC, challenges remain, with acquired resistance being a permanent issue. Novel EGFR-TKIs show promise in early-stage NSCLC, with resistance mechanisms being EGFR-dependent or -independent. MET inhibitors combined with EGFR-TKIs offer an effective option for overcoming resistance caused by MET amplification or overexpression. Ongoing research is focused on developing compounds to selectively inhibit EGFR20ins.

CURRENT OPINION IN ONCOLOGY (2021)

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Review Oncology

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

Reem Saleh et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Oncology

Insights into new mechanisms and models of cancer stem cell multidrug resistance

Y. Garcia-Mayea et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Small molecules targeting HIF-1α pathway for cancer therapy in recent years

Wendi Tang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer- Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation

Guangzhi Li et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection

Duo Sun et al.

ACS NANO (2020)

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Article Engineering, Biomedical

Gene/paclitaxel co-delivering nanocarriers prepared by framework-induced self-assembly for the inhibition of highly drug-resistant tumors

Chenglong Wang et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy

Peipei Yang et al.

ACTA BIOMATERIALIA (2020)

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Review Oncology

Mechanisms of immune evasion in bladder cancer

Paul L. Crispen et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Review Pharmacology & Pharmacy

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

Jinyun Dong et al.

DRUG RESISTANCE UPDATES (2020)

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Review Medicine, Research & Experimental

Is there a causal link between PTEN deficient tumors and immunosuppressive tumor microenvironment?

Vildan B. Cetintas et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Synergistic Antitumor Effects on Drug-Resistant Breast Cancer of Paclitaxel/Lapatinib Composite Nanocrystals

Jun Wang et al.

MOLECULES (2020)

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Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Oncology

Understanding genetic determinants of resistance to immune checkpoint blockers

Sandrine Aspeslagh et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Oncology

Resistance to Checkpoint Inhibition in Cancer Immunotherapy

Luisa Barrueto et al.

TRANSLATIONAL ONCOLOGY (2020)

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Review Oncology

Emerging role of PTEN loss in evasion of the immune response to tumours

Thiago Vidotto et al.

BRITISH JOURNAL OF CANCER (2020)

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Review Pharmacology & Pharmacy

Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors

Sabrina Dallavalle et al.

DRUG RESISTANCE UPDATES (2020)

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Review Pharmacology & Pharmacy

Nanomedicine to target multidrug resistant tumors

Elise Lepeltier et al.

DRUG RESISTANCE UPDATES (2020)

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Review Immunology

NK Cell Function Regulation by TGF-β-Induced Epigenetic Mechanisms

Stefano Regis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Autophagy in cancer: Recent advances and future directions

Mohd Ishaq et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Hyperthermia-Triggered On-Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy

Gao Junbin et al.

ADVANCED SCIENCE (2020)

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Review Oncology

DNA Damage/Repair Management in Cancers

Jehad F. Alhmoud et al.

CANCERS (2020)

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Article Nanoscience & Nanotechnology

Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal

Ya-Xuan Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Boosting Natural Killer Cell-Based Cancer Immunotherapy with Selenocystine/Transforming Growth Factor-Beta Inhibitor-Encapsulated Nanoemulsion

Chang Liu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Photoactivated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

Rui Sun et al.

ACS NANO (2020)

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Review Oncology

Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications

Johann S. Bergholz et al.

CLINICAL CANCER RESEARCH (2020)

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Review Pharmacology & Pharmacy

New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma

Michele Dal Bo et al.

DRUG RESISTANCE UPDATES (2020)

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Review Biochemistry & Molecular Biology

PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy

Fabiana Conciatori et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Editorial Material Immunology

Editorial: Molecular Strategies Aimed to Boost NK Cell-Based Immunotherapy of Cancer

Loredana Cifaldi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

Chih Kit Chung et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

Elucidating a Thermoresponsive Multimodal Photo-Chemotherapeutic Nanodelivery Vehicle to Overcome the Barriers of Doxorubicin Therapy

Jyothi B. Nair et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Precisely Assembled Nanoparticles against Cisplatin Resistance via Cancer-Specific Targeting of Mitochondria and Imaging-Guided Chemo-Photothermal Therapy

Gang-Gang Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Pharmacology & Pharmacy

Lymphatic immunomodulation using engineered drug delivery systems for cancer immunotherapy

Margaret P. Manspeaker et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Engineering, Biomedical

Biodegradable Poly(gamma-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy

Ming Zhang et al.

BIOMATERIALS (2020)

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Article Oncology

Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

Yuhong Lu et al.

CANCER RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Spatiotemporally Targeted Nanomedicine Overcomes Hypoxia-Induced Drug Resistance of Tumor Cells after Disrupting Neovasculature

Jinjin Chen et al.

NANO LETTERS (2020)

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Review Biochemistry & Molecular Biology

Chemical strategies to overcome resistance against targeted anticancer therapeutics

Rudolf Pisa et al.

NATURE CHEMICAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review

Yolla Haibe et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Reduction-sensitive platinum (IV)-prodrug nano-sensitizer with an ultra-high drug loading for efficient chemo-radiotherapy of Pt-resistant cervical cancer in vivo

Kejun Luo et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biochemistry & Molecular Biology

Tackling Resistance to Cancer Immunotherapy: What Do We Know?

Soehartati A. Gondhowiardjo et al.

MOLECULES (2020)

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Article Engineering, Biomedical

Near Infrared-Activatable Platinum-Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance

Andrea C. del Valle et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Pharmacology & Pharmacy

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

Nuray Erin et al.

DRUG RESISTANCE UPDATES (2020)

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Article Nanoscience & Nanotechnology

Polyplexes by Polymerized Dequalinium and Bifunctional Aptamer for Mitochondrial Targeting Drug Release to Overcome Drug Resistance

Duo Gao et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Medicine, General & Internal

CPX-351 daunorubicin-cytarabine liposome: a novel formulation to treat patients with newly diagnosed secondary acute myeloid leukemia

Alessandro Cafaro et al.

MINERVA MEDICA (2020)

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Review Oncology

Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance

Sara M. Elgendy et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Chemistry, Multidisciplinary

Microneedles loaded with anti-PD-1-cisplatin nanoparticles for synergistic cancer immuno-chemotherapy

Xinmiao Lan et al.

NANOSCALE (2020)

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Review Oncology

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance

Wanjiru Muriithi et al.

CANCER BIOLOGY & MEDICINE (2020)

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Review Medicine, Research & Experimental

Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer

Dinoop Ravindran Menon et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFRT790M mutation

Weimin Yin et al.

THERANOSTICS (2020)

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Article Chemistry, Physical

Endosome/lysosome-detained supramolecular nanogels as an efflux retarder and autophagy inhibitor for repeated photodynamic therapy of multidrug-resistant cancer

Xiaodong Zhang et al.

NANOSCALE HORIZONS (2020)

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Article Medicine, Research & Experimental

One-pot synthesis of a microporous organosilica-coated cisplatin nanoplatform for HIF-1-targeted combination cancer therapy

Xiaojuan Zhang et al.

THERANOSTICS (2020)

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Review Oncology

A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy

Yu Fujiwara et al.

CANCER DRUG RESISTANCE (2020)

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Review Immunology

Tumour-intrinsic resistance to immune checkpoint blockade

Anusha Kalbasi et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Acquired resistance to cancer immunotherapy

Arianna Draghi et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

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Article Chemistry, Multidisciplinary

The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery

Meng Zheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Pharmacology & Pharmacy

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

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PHARMACEUTICS (2019)

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Article Engineering, Biomedical

Core-matched nanoassemblies for targeted co-delivery of chemotherapy and photosensitizer to treat drug-resistant cancer

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ACTA BIOMATERIALIA (2019)

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Review Biochemistry & Molecular Biology

Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy

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BIOORGANIC & MEDICINAL CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

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EXPERT OPINION ON DRUG DISCOVERY (2019)

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Article Multidisciplinary Sciences

Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Medicine, General & Internal

An Overview of Cancer Drugs Approved by the US Food and Drug Administration Based on the Surrogate End Point of Response Rate

Emerson Y. Chen et al.

JAMA INTERNAL MEDICINE (2019)

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Review Oncology

Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

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CANCERS (2019)

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Article Oncology

Cause-and-Effect relationship between FGFR1 expression and epithelial-mesenchymal transition in EGFR-mutated non-small cell lung cancer cells

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LUNG CANCER (2019)

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Article Medicine, Research & Experimental

Erythrocyte Membrane-Camouflaged IR780 and DTX Coloading Polymeric Nanoparticles for Imaging-Guided Cancer Photo-Chemo Combination Therapy

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MOLECULAR PHARMACEUTICS (2019)

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Article Nanoscience & Nanotechnology

Janus Gold Triangle-Mesoporous Silica Nanoplatforms for Hypoxia-Activated Radio-Chemo-Photothermal Therapy of Liver Cancer

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Medicine, Research & Experimental

A nuclear targeted Dox-aptamer loaded liposome delivery platform for the circumvention of drug resistance in breast cancer

Xin Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Oncology

Treg-mediated acquired resistance to immune checkpoint inhibitors

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CANCER LETTERS (2019)

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Article Immunology

TGF-β regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression

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IMMUNOBIOLOGY (2019)

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Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin

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PLOS ONE (2019)

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Review Oncology

PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition

Daniele Cretella et al.

CANCERS (2019)

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Article Engineering, Biomedical

Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL/FasL signaling

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Article Chemistry, Multidisciplinary

Selectively targeting tumor-associated macrophages and tumor cells with polymeric micelles for enhanced cancer chemo-immunotherapy

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JOURNAL OF CONTROLLED RELEASE (2019)

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Article Nanoscience & Nanotechnology

Iguratimod encapsulated PLGA-NPs improves therapeutic outcome in glioma, glioma stem-like cells and temozolomide resistant glioma cells

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

FGFR1 Induces Acquired Resistance Against Gefitinib By Activating AKT/mTOR Pathway In NSCLC

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ONCOTARGETS AND THERAPY (2019)

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Review Oncology

Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story

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CANCERS (2019)

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Review Biotechnology & Applied Microbiology

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine

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BIOMOLECULES (2019)

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Review Oncology

Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism

Jingjing Zhu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Oncology

Role of osimertinib in the treatment of EGFR-mutation positive non-small-cell lung cancer

Jennifer W. Carlisle et al.

FUTURE ONCOLOGY (2019)

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Review Cell Biology

Cancer stem cells (CSCs) in cancer progression and therapy

Masoud Najafi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Chemistry, Multidisciplinary

Enhancing solid tumor therapy with sequential delivery of dexamethasone and docetaxel engineered in a single carrier to overcome stromal resistance to drug delivery

Lu Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Oncology

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Review Oncology

State-of-the-art strategies for targeting the DNA damage response in cancer

Patrick G. Pilie et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Article Pharmacology & Pharmacy

Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Minglu Zhou et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Article Nanoscience & Nanotechnology

Temporally Controlled Photothermal/Photodynamic and Combined Therapy for Overcoming Multidrug Resistance of Cancer by Polydopamine Nanoclustered Micelles

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

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ADVANCED MATERIALS (2019)

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Review Respiratory System

Resistance to molecularly targeted therapy in non-small-cell lung cancer

Tetsuhiko Asao et al.

RESPIRATORY INVESTIGATION (2019)

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Article Medicine, Research & Experimental

Tumor acidity activated triphenylphosphonium-based mitochondrial targeting nanocarriers for overcoming drug resistance of cancer therapy

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THERANOSTICS (2019)

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Article Medicine, Research & Experimental

pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance

Wenjing Huang et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

A dual pH-sensitive liposomal system with charge-reversal and NO generation for overcoming multidrug resistance in cancer

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NANOSCALE (2019)

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Article Nanoscience & Nanotechnology

Light-Activated ROS-Responsive Nanoplatform Codelivering Apatinib and Doxorubicin for Enhanced Chemo-Photodynamic Therapy of Multidrug-Resistant Tumors

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Oncology

Efficacy and safety findings from DREAM: a phase III study of DHP107 (oral paclitaxel) versus i.v. paclitaxel in patients with advanced gastric cancer after failure of first-line chemotherapy

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ANNALS OF ONCOLOGY (2018)

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Review Oncology

Mechanisms of resistance to immune checkpoint inhibitors

Russell W. Jenkins et al.

BRITISH JOURNAL OF CANCER (2018)

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Review Oncology

Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies

Zheng-Hai Tang et al.

CANCER LETTERS (2018)

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Redox-responsive cisplatin nanogels for anticancer drug delivery

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CHEMICAL COMMUNICATIONS (2018)

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Article Oncology

The challenge of drug resistance in cancer treatment: a current overview

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CLINICAL & EXPERIMENTAL METASTASIS (2018)

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Review Immunology

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

Shetal A. Patel et al.

IMMUNITY (2018)

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Article Pharmacology & Pharmacy

Co-delivery of doxorubicin and imatinib by pH sensitive cleavable PEGylated nanoliposomes with folate-mediated targeting to overcome multidrug resistance

Yan Chen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Oncology

Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR

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LUNG CANCER (2018)

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Article Chemistry, Multidisciplinary

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

Guangbao Yang et al.

NANO LETTERS (2018)

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Review Biotechnology & Applied Microbiology

Kinase inhibitors: the road ahead

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NATURE REVIEWS DRUG DISCOVERY (2018)

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Article Multidisciplinary Sciences

Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models

Folashade Otegbeye et al.

PLOS ONE (2018)

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Article Cell Biology

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

Chao Wang et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Cell & Tissue Engineering

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Lan Thi Hanh Phi et al.

STEM CELLS INTERNATIONAL (2018)

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Review Oncology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations

Judith A. Seidel et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Oncology

Mechanisms and Therapy for Cancer Metastasis to the Brain

Federica Franchino et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis

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INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

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Article Pharmacology & Pharmacy

Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer

Yoann Montigaud et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Medicine, Research & Experimental

Co-delivery of Docetaxel and Disulfonate Tetraphenyl Chlorin in One Nanoparticle Produces Strong Synergism between Chemo- and Photodynamic Therapy in Drug-Sensitive and -Resistant Cancer Cells

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MOLECULAR PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer

Xuejiao Song et al.

NANO LETTERS (2018)

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Review Chemistry, Medicinal

Targeting EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) resistance mutations in NSCLC: Current developments in medicinal chemistry

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MEDICINAL RESEARCH REVIEWS (2018)

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Article Multidisciplinary Sciences

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Nutrition & Dietetics

Selenium, Selenoproteins, and Immunity

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NUTRIENTS (2018)

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Article Chemistry, Multidisciplinary

ATailored DNA Nanoplatform for Synergistic RNAi-/Chemotherapy of Multidrug-Resistant Tumors

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Medicine, Research & Experimental

Erlotinib-Guided Self-Assembled Trifunctional Click Nanotheranostics for Distinguishing Druggable Mutations and Synergistic Therapy of Nonsmall Cell Lung Cancer

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MOLECULAR PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFR(T790M)-Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery

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SMALL (2018)

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Article Pharmacology & Pharmacy

Biodegradable Nanoparticles Mediated Co-delivery of Erlotinib (ELTN) and Fedratinib (FDTN) Toward the Treatment of ELTN-Resistant Non-small Cell Lung Cancer (NSCLC) via Suppression of the JAK2/STAT3 Signaling Pathway

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FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer

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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

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Review Oncology

Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma

Tuba N. Gide et al.

CLINICAL CANCER RESEARCH (2018)

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Article Oncology

A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy

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CANCER RESEARCH (2018)

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Article Oncology

Targeting the Gatekeeper: Osimertinib in EGFR T790M Mutation-Positive Non-Small Cell Lung Cancer

Ferdinandos Skoulidis et al.

CLINICAL CANCER RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

Cynthia I. Chude et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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News Item Oncology

Osimertinib effective in EGFR T790M-positive lung cancer

Susan Mayor

LANCET ONCOLOGY (2017)

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Article Medicine, Research & Experimental

Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance

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MOLECULAR PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat

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NANO LETTERS (2017)

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Article Chemistry, Multidisciplinary

Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy

Wei Zhou et al.

NANOSCALE (2017)

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Article Multidisciplinary Sciences

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

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SCIENCE (2017)

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T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

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NATURE COMMUNICATIONS (2017)

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Article Nanoscience & Nanotechnology

Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer

Fengqiao Li et al.

BIOMATERIALS (2017)

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Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

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Article Nanoscience & Nanotechnology

Trackable Mitochondria-Targeting Nanomicellar Loaded with Doxorubicin for Overcoming Drug Resistance

Ye Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Biochemistry & Molecular Biology

ATP-dependent activity and mitochondrial localization of drug efflux pumps in doxorubicin-resistant breast cancer cells

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Article Engineering, Biomedical

Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer

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BIOMATERIALS (2017)

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Article Biophysics

Bypassing multidrug resistant ovarian cancer using ultrasound responsive doxorubicin/curcumin co-deliver alginate nanodroplets

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COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Nanoscience & Nanotechnology

Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Chemistry, Multidisciplinary

Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

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ADVANCED MATERIALS (2017)

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Article Oncology

MET receptor inhibition: Hope against resistance to targeted therapies?

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BULLETIN DU CANCER (2017)

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Review Pharmacology & Pharmacy

Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance

Maya Bar-Zeev et al.

DRUG RESISTANCE UPDATES (2017)

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Article Oncology

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

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CANCER DISCOVERY (2016)

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Article Oncology

Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

Ruud Weijer et al.

ONCOTARGET (2016)

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Article Chemistry, Multidisciplinary

Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor

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ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

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ACS NANO (2016)

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Review Biochemistry & Molecular Biology

Cytokines in cancer drug resistance: Cues to new therapeutic strategies

Valerie Sloane Jones et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2016)

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Article Oncology

Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals

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CANCER LETTERS (2016)

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Review Oncology

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

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CANCER LETTERS (2016)

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Article Oncology

Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy

Ji Young Yoo et al.

CLINICAL CANCER RESEARCH (2016)

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Review Oncology

Biomarkers of Response and Resistance to DNA Repair Targeted Therapies

Elizabeth H. Stover et al.

CLINICAL CANCER RESEARCH (2016)

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Review Oncology

Dominant mechanisms of primary resistance differ from dominant mechanisms of secondary resistance to targeted therapies

Ksenija Asic

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

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Review Biochemistry & Molecular Biology

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

Kristopher A. Sarosiek et al.

FEBS JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Chao Wang et al.

NANO LETTERS (2016)

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Article Chemistry, Multidisciplinary

Actively targeting D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer

Di Jiang et al.

NANOSCALE (2016)

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Review Immunology

Targeting natural killer cells in cancer immunotherapy

Camille Guillerey et al.

NATURE IMMUNOLOGY (2016)

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Article Oncology

Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia

Dan Douer

ONCOLOGIST (2016)

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Article Chemistry, Multidisciplinary

pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment

Zuhong Li et al.

SMALL (2016)

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Review Oncology

Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory et al.

TRENDS IN CANCER (2016)

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Article Chemistry, Multidisciplinary

Multipronged Design of Light-Triggered Nanoparticles To Overcome Cisplatin Resistance for Efficient Ablation of Resistant Tumor

Yanli Li et al.

ACS NANO (2015)

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Review Medicine, Research & Experimental

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

Michael Goldstein et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Multidisciplinary Sciences

Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

Haiquan Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Oncology

Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Sergey V. Karakashev et al.

CANCER MANAGEMENT AND RESEARCH (2015)

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Article Multidisciplinary Sciences

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Madhav D. Sharma et al.

SCIENCE ADVANCES (2015)

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Article Chemistry, Multidisciplinary

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

Kvar C. L. Black et al.

ACS NANO (2014)

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Review Biotechnology & Applied Microbiology

Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers

Vasilios Tsouris et al.

BIOTECHNOLOGY ADVANCES (2014)

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Review Oncology

Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches

Qiong Wu et al.

CANCER LETTERS (2014)

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Review Oncology

The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets

Steven L. Wood et al.

CANCER TREATMENT REVIEWS (2014)

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Review Nanoscience & Nanotechnology

Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Review Chemistry, Multidisciplinary

Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: Current progress and advances

Nishant S. Gandhi et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Chemistry, Multidisciplinary

ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors

Jiexin Deng et al.

PHARMACEUTICAL RESEARCH (2014)

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Article Multidisciplinary Sciences

被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Oncology

Clinical Comparison between Paclitaxel Liposome (Lipusu®) and Paclitaxel for Treatment of Patients with Metastatic Gastric Cancer

Xu Xu et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

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Article Oncology

Targeting Hypoxia for Sensitization of Tumors to Radio- and Chemotherapy

Khaled Ghattass et al.

CURRENT CANCER DRUG TARGETS (2013)

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Article Chemistry, Multidisciplinary

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

Yiran Zheng et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

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Review Pharmacology & Pharmacy

Collateral sensitivity as a strategy against cancer multidrug resistance

Kristen M. Pluchino et al.

DRUG RESISTANCE UPDATES (2012)

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Review Chemistry, Medicinal

Advances of Paclitaxel Formulations Based on Nanosystem Delivery Technology

C. Luo et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)

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Review Oncology

DNA repair dysregulation from cancer driver to therapeutic target

Nicola J. Curtin

NATURE REVIEWS CANCER (2012)

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Review Oncology

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

Peter Bouwman et al.

NATURE REVIEWS CANCER (2012)

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Article Engineering, Biomedical

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

Kai Xiao et al.

BIOMATERIALS (2011)

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Review Biochemistry & Molecular Biology

Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases

Zhe-Sheng Chen et al.

FEBS JOURNAL (2011)

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Review Oncology

Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance

Yongjian Zhu et al.

CANCER TREATMENT REVIEWS (2009)

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Review Cell Biology

Hypoxia-inducible factors in stem cells and cancer

Jolly Mazumdar et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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Review Chemistry, Multidisciplinary

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

Paolo Decuzzi et al.

PHARMACEUTICAL RESEARCH (2009)

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Review Biotechnology & Applied Microbiology

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

Michelle Longmire et al.

NANOMEDICINE (2008)

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Review Oncology

DNA repair pathways as targets for cancer therapy

Thomas Helleday et al.

NATURE REVIEWS CANCER (2008)

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Review Medicine, General & Internal

Effect of a new leuprorelin formulation on testosterone levels in patients with advanced prostate cancer

R BergeS et al.

CURRENT MEDICAL RESEARCH AND OPINION (2006)

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Review Oncology

Tumour stem cells and drug resistance

M Dean et al.

NATURE REVIEWS CANCER (2005)

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Article Oncology

Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide

T Souslova et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

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Article Medical Laboratory Technology

Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell

G Bosson

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2003)

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Article Biochemistry & Molecular Biology

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

L Rothem et al.

BIOCHEMICAL JOURNAL (2002)

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Article Oncology

Phase IV study of liposomal daunorubicin (DaunoXome) in AIDS-related Kaposi sarcoma

E Rosenthal et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2002)

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Article Biochemistry & Molecular Biology

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

S Arico et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters

U Stein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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