☆ 4.7 Review

Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities

PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

Lei Sun et al.

Summary: The rapid development of cell-based theranostics has attracted significant attention. In this study, customized liposomes were combined with neutrophils using nanoengineering method to generate acoustic oxygen-carrying cells called Acouscyte/O-2 for the diagnosis and treatment of cancer. Acouscyte/O-2 not only carries oxygen but also exhibits characteristics such as long circulation, inflammation-triggered recruitment and decomposition. It selectively accumulates in tumors, enhances tumor oxygen levels, and triggers anticancer sonodynamics through ultrasound stimulation, leading to complete tumor obliteration.

ADVANCED MATERIALS (2022)

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Article Engineering, Aerospace

Establishment of super sonic inlet flow pattern monitoring system: A workflow

Yi-Lin Wang et al.

Summary: This paper proposes a workflow for establishing an online monitoring system for supersonic inlet flow patterns using pressure sensors to reduce the negative effects of the buzz flow state. By building an experimental system and training sub classifiers, efficient extraction of highly perturbed signal information and high classification accuracy of different flow patterns are achieved.

AEROSPACE SCIENCE AND TECHNOLOGY (2022)

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Article Critical Care Medicine

The use of ultrasound in the acute setting: Lessons learned after 30 years

Grace F. Rozycki

Summary: This article discusses the crucial events in the development of ultrasound usage by surgeons to assess patients. The lessons learned from these experiences may be valuable in the future when addressing challenges associated with the implementation of ultrasound by surgeons.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2022)

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Article Acoustics

Effect of Ultrasound-Stimulated Microbubbles and Hyperthermia on Tumor Vasculature of Breast Cancer Xenograft

Deepa Sharma et al.

Summary: The present study investigated the treatment effects of ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) on breast tumor vasculature. Results showed that both USMB and HT alone or together significantly reduced tumor blood flow, tumor oxygenation, and vessel count, while increasing cell death response.

JOURNAL OF ULTRASOUND IN MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Detection and Characterization of Sentinel Lymph Node by Ultrasound Molecular Imaging with B7-H3-Targeted Microbubbles in Orthotopic Breast Cancer Model in Mice

Zhongqian Hu et al.

Summary: Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imaging methods, such as B7-H3-targeted molecular-ultrasound imaging, can play a vital role in tumor staging and prognostic evaluation. This study demonstrated the efficacy of B7-H3-targeted microbubbles for SLN detection and characterization in a mouse model of orthotopic breast cancer.

MOLECULAR IMAGING AND BIOLOGY (2022)

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Article Nanoscience & Nanotechnology

Combined legumain- and integrin-targeted nanobubbles for molecular ultrasound imaging of breast cancer

Xue Mi et al.

Summary: In this study, we synthesized nanobubbles with a small size and modified their surface with peptides targeting tumor cells and tumor neovasculature. The dual targeted nanobubbles showed efficient and specific imaging of breast cancer in both in vitro and in vivo experiments, demonstrating their potential for cancer diagnosis and monitoring.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Article Endocrinology & Metabolism

Development of a novel castration-resistant orthotopic prostate cancer model in New Zealand White rabbit

Yu Wang et al.

Summary: In this study, a prostate cancer model was successfully established in immunosuppressed rabbits, providing a clinically relevant intermediate step for assessing preclinical interventions. The minimally invasive ultrasound-guided tumor cell injection proved to be a better method compared to laparotomy, allowing for shorter recovery time for the rabbits.

PROSTATE (2022)

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Article Orthopedics

Diagnostic ultrasound of tendon injuries in the setting of distal radius fractures

Simon Sun et al.

Summary: This study retrospectively analyzed 226 wrists of 221 patients with distal radius fractures, revealing that certain wrist tendons, particularly EPL and FPL, are vulnerable to injury post-fracture. Ultrasound examination is accurate and useful for detecting tendon injuries and sources of tendon irritation, providing valuable guidance for clinical management.

SKELETAL RADIOLOGY (2022)

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Article Oncology

Clinical and Computed Tomography Characteristics for Early Diagnosis of Peripheral Small-cell Lung Cancer

Xiaochuan Zhang et al.

Summary: Through the analysis of clinical and CT characteristics, it was found that male patients with emphysema and peripheral solid nodules with homogeneous density, bronchial cutoff sign, and hilar lymph node enlargement, but without spiculation or vessel convergence, should be highly suspected of having peripheral small-cell lung cancer (pSCLC).

CANCER MANAGEMENT AND RESEARCH (2022)

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Review Medicine, General & Internal

Nanomaterials-Based Urinary Extracellular Vesicles Isolation and Detection for Non-invasive Auxiliary Diagnosis of Prostate Cancer

Na Wang et al.

Summary: Extracellular vesicles (EVs) are natural nanoparticles secreted by cells in the body and can be used as important markers for disease diagnosis and prognosis. Nanomaterial-based platforms have been innovatively explored for the isolation and detection of EVs from urine, providing higher selectivity and sensitivity. This review focuses on the nanomaterials used in the isolation and detection of urinary EVs, and presents urinary EV-derived biomarkers for prostate cancer diagnosis.

FRONTIERS IN MEDICINE (2022)

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Article Oncology

High-intensity focused ultrasound therapy for pediatric and adolescent vulvar lichen sclerosus

Sili He et al.

Summary: The study retrospectively evaluated the efficacy and safety of high-intensity focused ultrasound (HIFU) for vulvar lichen sclerosus (VLS) in pediatric and adolescent patients. The results showed that HIFU was effective and relatively safe for the treatment of VLS, but attention should be paid to possible skin burns.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2022)

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Review Nanoscience & Nanotechnology

Advances in Nanoliposomes for the Diagnosis and Treatment of Liver Cancer

Yitong Li et al.

Summary: Liver cancer is a gradually increasing disease worldwide, and its diagnosis and treatment still face challenges. The emergence of liposomes has provided new possibilities for the treatment of liver cancer.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

FN3 linked nanobubbles as a targeted contrast agent for US imaging of cancer-associated human PD-L1

Uday S. Kumar et al.

Summary: PD-L1 targeted therapies may be effective for various cancers. Non-invasive diagnostic and prognostic molecular imaging platforms can enhance clinical assessment of PD-L1 tumor status. By utilizing ultra-stable nanobubbles as a contrast agent, functionalized with nanobody targeting human PD-L1, molecular imaging of the tumor is possible. The results showed a three-fold increase in contrast signal compared to non-targeted nanobubbles. This research has the potential for clinical translation and prognostic evaluation of patient response to PD-L1 targeted immunotherapy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Medicine, General & Internal

A Novel Technique Using Ultrasonic Shears Versus Traditional Methods of Reduction of Bilateral Labia Minora Hypertrophy: A Retrospective Case-Control Study

Thuan H. Le et al.

Summary: This study compares the clinical outcomes of bilateral labia minora hypertrophy reduction using ultrasonic shears versus traditional methods. The results show that ultrasonic shears significantly reduce the operative time, but no significant differences were found in other outcomes.

MILITARY MEDICINE (2022)

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Article Engineering, Chemical

Effect of OHMIC heating and ultrasound on functional properties of biodegradable gelatin-based films

Victoria Hermes de Vargas et al.

Summary: This study evaluated the effects of ohmic heating and ultrasound on the functional properties of biodegradable gelatin-based films. The results showed that both treatments altered the mechanical properties, structural order, and thermal stability of the films, but had no effect on film thickness, moisture content, water solubility, and biodegradability.

POLYMER ENGINEERING AND SCIENCE (2022)

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Article Chemistry, Analytical

Development of an Accurate and Robust Air-Coupled Ultrasonic Time-of-Flight Measurement Technique

Benjamin Buehling et al.

Summary: This study presents a non-invasive and accurate method for in-air ranging and time-of-flight (ToF) determination that is robust to changing ambient conditions or waveform variations. It utilizes the azimuthal directivity of a laser Doppler vibrometer and autocorrelation technique to determine the in-air travel time and time of entry of the acoustic signal. The same signal is also used as a reference for determining the ToF through the specimen via cross-correlation. Experiments on a polyamide specimen verified the method, achieving a ranging accuracy of <0.1 mm and a transmission ToF accuracy of 0.3 μs.

SENSORS (2022)

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Article Acoustics

AUTOMATIC PLACENTA LOCALIZATION FROM ULTRASOUND IMAGING IN A RESOURCE-LIMITED SETTING USING A PREDEFINED ULTRASOUND ACQUISITION PROTOCOL AND DEEP LEARNING

Martijn Schilpzand et al.

Summary: This study presents a method to automatically detect low-lying placenta or placenta previa from 2-D ultrasound imaging using a deep learning model. The method achieved high accuracy in placenta segmentation and classification, and showed feasibility in resource-limited settings.

ULTRASOUND IN MEDICINE AND BIOLOGY (2022)

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Article Acoustics

QUANTITATIVE ANALYSIS OF ACOUSTIC PRESSURE FOR SONOPHORESIS AND ITS EFFECT ON TRANSDERMAL PENETRATION

Yuta Kurashina et al.

Summary: Ultrasound is a promising non-invasive technique for transdermal delivery, and a new device was designed to investigate the mechanism of sonophoresis. The experiments showed that the acoustic pressure and cavitation onset are sensitive to the subcutaneous support material, and the penetration of particles depends on their size, material, and the hardness of the subcutaneous support.

ULTRASOUND IN MEDICINE AND BIOLOGY (2022)

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Article Obstetrics & Gynecology

Enablers and barriers to introduction of obstetrics ultrasound service at primary care facilities in a resource-limited setting: a qualitative study in four regions of Ethiopia

Meselech Assegid Roro et al.

Summary: This qualitative study examined the facilitators and barriers to introducing obstetric ultrasound in resource-limited settings like Ethiopia. The study found that increased knowledge and skills of providers, improved motivation, increased utilization and improved quality of care were important health system enablers. Perceived limited knowledge and skills of providers and the small size of ultrasound machines were identified as client-related barriers. Overcoming these barriers can help maximize and sustain the use of obstetric ultrasound technology.

BMC PREGNANCY AND CHILDBIRTH (2022)

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Article Pharmacology & Pharmacy

Safety Assessment of Ultrasound-Assisted Intravesical Chemotherapy in Normal Dogs: A Pilot Study

Noboru Sasaki et al.

Summary: Intravesical chemotherapy is a treatment option for non-muscle invasive bladder cancer, and drug delivery technologies can enhance its efficacy. Ultrasound-triggered microbubble cavitation may be an effective drug delivery technology in the urinary bladder. The combination of ultrasound and microbubbles does not increase drug concentration in the plasma and does not cause damage to the urothelium.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Monodisperse magnetic lecithin-PFP submicron bubbles as dual imaging contrast agents for ultrasound (US) and MRI

Hira Waqar et al.

Summary: Magnetic microbubbles synthesized in this study showed a negative contrast effect in MRI and provided good contrast in ultrasound imaging at lower concentrations, with excellent hemocompatibility demonstrated. Optimization of concentration was necessary to achieve the best effect on both modalities.

RSC ADVANCES (2022)

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Article Engineering, Chemical

Ultrasonic Vibration Hot Embossing A Novel Technique for Molding Plastic Microstructure

S-J Liu et al.

Summary: This study proposed a novel hot embossing method using ultrasonic vibration as a heat generator for molding microstructures onto the surface of polymeric plates. The results suggest that ultrasonic vibration hot embossing can provide an effective way of replicating micro-features, although improvements in the design of the ultrasonic vibration machine are needed to make the process feasible.

INTERNATIONAL POLYMER PROCESSING (2022)

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Review Surgery

Systematic Review of Comparison of use of Ultrasonic Scalpel Versus Conventional Haemostatic Techniques in Performing Thyroid Surgery

Hitesh Sarda et al.

Summary: This study compares the application of ultrasonic scalpel and conventional ligature techniques in thyroid surgery and finds that ultrasonic scalpel can reduce operative time and postoperative complications, and improve the safety of surgery.

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY (2022)

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Article Cell Biology

Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment

Martin Gabay et al.

Summary: The main obstacle in treating brain tumors is the lack of effective therapeutic strategies capable of penetrating the blood-brain barrier.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

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Article Nanoscience & Nanotechnology

Brain Delivery of Curcumin Through Low-Intensity Ultrasound-Induced Blood-Brain Barrier Opening via Lipid-PLGA Nanobubbles

Yiran Yan et al.

Summary: This study improved the solubility of curcumin and developed Cur-NBs for brain delivery of curcumin against PD by combining with LIFU-mediated BBB opening. Cur-NBs serve as a platform for potential drugs that have difficulty crossing the BBB to treat PD and other CNS diseases.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biology

Subsequent Ultrasound Vascular Targeting Therapy of Hepatocellular Carcinoma Improves the Treatment Efficacy

Laith R. Sultan et al.

Summary: The study evaluated the use of repeated subsequent AVUS therapy to optimize therapeutic efficacy in treating hepatocellular carcinoma (HCC). Short intervals between subsequent AVUS treatments showed significant improvement in tumor perfusion reduction, while longer intervals resulted in diminished effects. The findings suggest the importance of tumor viability in maximizing the therapeutic effects of targeted tumor vasculature therapies.

BIOLOGY-BASEL (2021)

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Article Nanoscience & Nanotechnology

Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites

Chiao-Ling Cheng et al.

Summary: The blood-brain barrier is a crucial barrier that protects the brain from external substances. Utilizing nanotechnology and ultrasound induction, this barrier can be temporarily opened for potential brain disease treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Endocrinology & Metabolism

Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis

Henrik Heinen et al.

Summary: This study establishes a novel methodology using experimental ultrasound techniques to assess the morphological, functional, and molecular features of breast cancer bone metastases, compared with magnetic resonance imaging and histological analysis. The results show that ultrasound techniques can effectively characterize osteolytic lesions and that molecular ultrasound allows for the non-invasive assessment of increased VEGFR2 expression in skeletal lesions.

BONE (2021)

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Article Oncology

Tumor perfusion enhancement by ultrasound stimulated microbubbles potentiates PD-L1 blockade of MC38 colon cancer in mice

Ningshan Li et al.

Summary: Cancer immunotherapy, particularly through ultrasound stimulated microbubble cavitation (USMC), holds promise in eradicating solid tumors by promoting tumor perfusion, increasing CD8(+) T cells infiltration, and enhancing anti-PD-L1 antibody delivery. The combination therapy of optimized USMC with anti-PD-L1 antibody not only enhances tumor perfusion and vascular normalization, but also significantly increases tumor infiltrating CD8(+) T cells, leading to greater tumor growth inhibition and longer survival compared to monotherapies.

CANCER LETTERS (2021)

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Article Oncology

CMBs carrying PTX and CRISPR/Cas9 targeting C-erbB-2 plasmids interfere with endometrial cancer cells

Siyuan Peng et al.

Summary: The study investigated the effect of CMBs carrying PTX and C-erbB-2 knockout plasmid on endometrial cancer cells, revealing that C-erbB-2 knockout inhibits proliferation, migration, and invasion of HEC-1A cells. Loading PTX and plasmid simultaneously may be a novel combination therapy with great potential. C-erbB-2 may regulate cell proliferation by downregulating expression of P21 and P27 in HEC-1A cells.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Ultrasound-Based Molecular Imaging of Tumors with PTPmu Biomarker-Targeted Nanobubble Contrast Agents

Mette L. Johansen et al.

Summary: In this study, molecularly-targeted nanobubbles directed at a cancer biomarker PTPmu showed more rapid and greater tumor enhancement compared to non-targeted nanobubbles, indicating their potential for recognizing tumors using molecular ultrasound imaging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemical Research Methods

Process validation, current good manufacturing practice production, dosimetry, and toxicity studies of the carbonic anhydrase IX imaging agent [111In]In-XYIMSR-01 for phase I regulatory approval

Ravindra A. De Silva et al.

Summary: In-111-XYIMSR-01 has been demonstrated as a safe and effective imaging agent for tumor diagnosis, with the maximum safe dose for human use determined through animal studies and dosimetry experiments.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2021)

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Article Mechanics

Numerical simulation of a confined cavitating gas bubble driven by ultrasound

Jacqueline Mifsud et al.

Summary: This study investigates the flow disturbance generated by an ultrasonically driven gas bubble confined in a narrow gap, revealing the doubled shear-stress magnitudes during collapse driven by ultrasonic signal and the different collapse regimes identified. The study highlights the differences in physics between acoustically driven bubbles and conventional laser-induced bubbles in experiments.

PHYSICS OF FLUIDS (2021)

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Article Nanoscience & Nanotechnology

Therapeutic efficacy and cardioprotection of nucleolin-targeted doxorubicin-loaded ultrasound nanobubbles in treating triple-negative breast cancer

Kejing Fang et al.

Summary: The AS1411-DOX-NBs showed enhanced tumour cell-killing ability in vitro by increasing the active uptake of drugs, and significantly inhibited the growth of TNBC xenografts while maintaining the weight and health of the mice. Echocardiography and pathological examination confirmed that AS1411-DOX-NBs effectively induced tumour tissue apoptosis and necrosis while reducing DOX-induced cardiotoxicity.

NANOTECHNOLOGY (2021)

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Article Physics, Applied

A Sonic Boom from a Thin Body and Local Heating Regions of an Incoming Supersonic Flow

A. V. Potapkin et al.

Summary: This study numerically solves the problem of sonic boom from a thin body and local heating region of an incoming supersonic flow. The results show that local heating can reduce the level of the sonic boom, with the level depending on the number of heating regions.

TECHNICAL PHYSICS (2021)

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Article Oncology

Ultrasound-mediated microbubbles cavitation enhanced chemotherapy of advanced prostate cancer by increasing the permeability of blood-prostate barrier

Haizhui Xia et al.

Summary: Ultrasound-induced cavitation combined with chemotherapy showed enhanced inhibition of prostate cancer cell viability and increased cell apoptosis, leading to significant tumor growth inhibition and prolonged survival in mice. The improved efficacy of chemotherapy was attributed to increased cell permeability induced by cavitation. Analysis also showed a slight increase in certain types of tumor-infiltrating lymphocytes after cavitation treatment during chemotherapy.

TRANSLATIONAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA

Yu Wang et al.

Summary: Ultrasound imaging is commonly used for guiding prostate biopsies, but accurately delineating tumors within the prostate gland remains challenging. This study evaluated a novel nanobubble ultrasound contrast agent targeted to PSMA, showing increased extravasation and retention in PSMA-expressing mouse tumors, potentially improving image-based detection and diagnosis of PCa in the future.

SCIENTIFIC REPORTS (2021)

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Article Acoustics

Effect of ruptured cavitated bubble cluster on the extent of the cell deformation by ultrasound

Peilin Cao et al.

Summary: The study found that changes in the structure of the bubble-cell model affect the degree of cell deformation, but without structural changes, the degree of cell deformation changes very little.

ULTRASONICS SONOCHEMISTRY (2021)

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Article Engineering, Biomedical

Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice

Paul Cressey et al.

Summary: Triggerable nanocarriers have the potential to improve the therapeutic index of existing anticancer agents by enabling localized delivery and release of therapeutic cargos. In this study, the first co-delivery of SN-38 and carboplatin was achieved using an MRI-visible thermosensitive liposome, showing both thermosensitivity and MR-imageability. The co-delivery resulted in significant improvements in anti-tumor activity in triple negative breast cancer xenografts tumors in mice.

BIOMATERIALS (2021)

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Article Oncology

Ultrasound-Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model

Jia-Ling Ruan et al.

Summary: This study investigates the use of ultrasound and microbubbles for targeted gemcitabine delivery to reduce normal-tissue toxicity in a murine orthotopic MIBC model. Results show a significant delay in tumor growth with both microbubble groups, while transient weight loss was observed but resolved within 10 days posttreatment. Ultrasound-mediated drug delivery methods did not exacerbate acute intestinal toxicity compared to conventional chemoradiation therapy.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Pharmacology & Pharmacy

Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy

Rui Ma et al.

Summary: NGR-modified nanobubbles containing CPP-DOX and CPP-siRNA demonstrate stable and controlled release of doxorubicin and siRNA, enhanced drug accumulation in tumors with sonication, and potential application prospects in cancer therapy.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Preparation of multifunctional nanobubbles and their application in bimodal imaging and targeted combination therapy of early pancreatic cancer

Hengli Yang et al.

Summary: IR780-NBs-DTX, a novel nanosized ultrasound contrast agents (UCAs), show excellent performance in dual-mode molecular targeted imaging and combined therapy for pancreatic cancer, with high efficiency and potential applications in precise detection and effective therapy of small and metastatic lesions.

SCIENTIFIC REPORTS (2021)

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Article Nanoscience & Nanotechnology

An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood-Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles

Ming-Hsien Chan et al.

Summary: This study developed a novel drug delivery system using nanobubbles to transport chemotherapy drugs to brain tumors, bypassing the blood-brain barrier with the help of high-intensity focused ultrasound. The inclusion of FePt nanoparticles enhances the resolution of imaging and helps guide the nanocomposite to tumor locations.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Gas-filled protein nanostructures as cavitation nuclei for molecule-specific sonodynamic therapy

Lin Song et al.

Summary: Sonodynamic therapy (SDT) utilizing gas vesicles (GVs) as stable nuclei enhances cavitation effects, increases cell toxicity, and exhibits specific targeting towards CD44(+) cells.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Pharmacological strategies for improving the prognosis of glioblastoma

Divyaansh Raj et al.

Summary: Advancements in brain cancer treatment have focused on combination therapies, immunotherapy, and drug delivery platforms. Beyond the treatments approved in 1996 and 2005, recent research on GBM has led to the development of new therapeutic approaches. Novel pharmacotherapies for GBM are currently being evaluated in clinical trials based on promising preclinical data.

EXPERT OPINION ON PHARMACOTHERAPY (2021)

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Article Acoustics

ULTRASOUND MOLECULAR IMAGING FOR THE GUIDANCE OF ULTRASOUND-TRIGGERED RELEASE OF LIPOSOMAL DOXORUBICIN AND ITS TREATMENT MONITORING IN AN ORTHOTOPIC PROSTATIC TUMOR MODEL IN RAT

Alexandre Helbert et al.

Summary: Encapsulation of drugs in liposomes is a promising approach in cancer therapy, with ultrasound-triggered sonosensitive liposomes showing potential for localized drug release. Experimental studies in animal models have demonstrated significant reduction in tumor size after ultrasound-triggered release of liposomes, guided by USMI for precise targeting.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Acoustics

SUPER-RESOLUTION ULTRASOUND LOCALIZATION MICROSCOPY ON A RABBIT LIVER VX2 TUMOR MODEL: AN INITIAL FEASIBILITY STUDY

Wei Zhang et al.

Summary: Ultrasound localization microscopy has the potential to image microvasculature in vivo without sacrificing imaging penetration depth, but has been limited by the reliance on super-resolution inference. This study presents a novel anesthesia protocol in rabbits to induce safe, controllable apnea periods for long image-acquisition times. The results demonstrate the necessity of the apneic protocol for correctly identifying poorly vascularized tumor cores and revealing tumoral microvascular architecture.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Acoustics

CHEMOTHERAPY AUGMENTATION USING LOW-INTENSITY ULTRASOUND COMBINED WITH MICROBUBBLES WITH DIFFERENT MECHANICAL INDEXES IN A PANCREATIC CANCER MODEL

Shuang Feng et al.

Summary: The study demonstrated that LIUS combined with microbubbles at MI = 0.3 could enhance tumor blood perfusion and increase local drug concentration in nude mice bearing pancreatic cancer. There were no significant differences in DOX concentration between the treatment and control sides at other MI values, and no tissue damage was observed in either side.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Multidisciplinary Sciences

Pre-screening for osteoporosis with calcaneus quantitative ultrasound and dual-energy X-ray absorptiometry bone density

Chia-Chi Yen et al.

Summary: The study demonstrated a significant correlation between calcaneal QUS and DXA in a Taiwanese population, indicating the importance of using QUS as a prescreening tool for osteoporosis, particularly in filtering out patients who may not necessarily require DXA examinations.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens

Seunghyun Lee et al.

Summary: It has been demonstrated that unfocused ultrasound with microbubbles and an interchangeable acoustic lens can enhance drug delivery efficiency by overcoming the limitations of a narrow pressure field. A concave lens suitable for an ultrasound-phased array probe was designed to optimize microbubble destruction, leading to successful drug delivery enhancement in in vitro and animal experiments. This system shows promise in providing sufficient ultrasound irradiation to microbubbles for improved drug delivery effectiveness.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Quantification of dynamic contrast-enhanced ultrasound (CEUS) in non-cystic breast lesions using external perfusion software

Ernst Michael Jung et al.

Summary: This clinical pilot study aimed to display typical perfusion results in patients with breast lesions using CEUS. The use of the perfusion parameters PE and AUC allowed for a good assessment of the risk of malignant breast lesions. There were no significant differences in perfusion evaluation for mean transit time, rise time, and time to peak between the center, margins, and surrounding tissue of the lesions.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Biotin-streptavidin-guided two-step pretargeting approach using PLGA for molecular ultrasound imaging and chemotherapy for ovarian cancer

Hang Zhou et al.

Summary: The study utilized a pre-targeting strategy to improve the treatment efficacy of ovarian cancer and ultrasound imaging results. The results showed that the pre-targeting technique significantly enhanced the targeting ability of PTX-loaded PLGA nanoparticles for ovarian cancer cells and improved therapeutic efficacy.

PEERJ (2021)

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Article Oncology

Cascade Release Nanocarriers for the Triple-Negative Breast Cancer Near-Infrared Imaging and Photothermal-Chemo Synergistic Therapy

Ke Li et al.

Summary: The combination of photothermal therapy (PTT) and chemotherapy is a promising approach for triple-negative breast cancer (TNBC), but hindered by issues such as asynchronous accumulation and toxic side effects. The new cascade release near-infrared imaging (NIFI) & thermal-chemo combination nanoparticles (CNC NPs) show exceptional potential, with a hollow core-shell structure and effective drug release mechanisms. These results provide a basis for the development of new clinical treatment methods for TNBC.

FRONTIERS IN ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

A new PLA-Tween composited drug-carrying C60-Fe3O4 multifunctional ultrasound contrast agent based on three kinds of lesions

Baoqing Gao et al.

Summary: A targeted drug-carrying microbubble system was designed and prepared, which showed promising drug-loading capabilities and stability for various drugs targeting different diseases.

RSC ADVANCES (2021)

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Article Oncology

Evaluation of Liposomal and Microbubbles Mediated Delivery of Doxorubicin in Two-Dimensional (2D) and Three-Dimensional (3D) Models for Breast Cancer

Melek Aydin et al.

Summary: The study demonstrated that DOX and LipoDOX exhibit anti-proliferative and apoptosis-inducing effects in breast cancer cells, with variations depending on the cell lines and 2D or 3D model types.

EUROPEAN JOURNAL OF BREAST HEALTH (2021)

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Article Medicine, Research & Experimental

Closed-loop trans-skull ultrasound hyperthermia leads to improved drug delivery from thermosensitive drugs and promotes changes in vascular transport dynamics in brain tumors

Chulyong Kim et al.

Summary: Effective drug delivery in brain tumors remains a major challenge in oncology. Local hyperthermia and stimuli-responsive delivery systems, such as thermosensitive liposomes, show promise in enhancing drug delivery in solid tumors but their application in intracranial malignancies is underexplored. This study demonstrated that combining closed-loop trans-skull MRgFUS hyperthermia with thermosensitive drugs can improve drug delivery and survival in gliomas, establishing a new paradigm for effective drug delivery in brain tumors.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo

Inoru Yokoe et al.

Summary: The combination of LBs and LIUS enhances the intratumoral delivery and antitumor effect of PLD, as evidenced by improved drug accumulation in tumor tissue and inhibited tumor growth.

DRUG DELIVERY (2021)

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Article Medicine, Research & Experimental

Development and evaluation of an ultrasound-triggered microbubble combined transarterial chemoembolization (TACE) formulation on rabbit VX2 liver cancer model

Doyeon Kim et al.

Summary: The study developed a new ultrasound-triggered TACE formulation that enhanced therapeutic efficacy by delivering doxorubicin-loaded nanoparticles to liver tumors effectively via microbubbles. In vivo experiments showed that this formulation significantly decreased tumor viability compared to conventional TACE formulation and effectively killed cancer cells in the tumor periphery.

THERANOSTICS (2021)

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Article Oncology

Synergistic anti-tumor effect of paclitaxel and miR-34a combined with ultrasound microbubbles on cervical cancer in vivo and in vitro

J. Yu et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

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Article Physics, Applied

Selective ablation of cancer cells with low intensity pulsed ultrasound

David R. Mittelstein et al.

APPLIED PHYSICS LETTERS (2020)

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Article Engineering, Biomedical

Superhydrophobic drug-loaded mesoporous silica nanoparticles capped with β-cyclodextrin for ultrasound image-guided combined antivascular and chemo-sonodynamic therapy

Yi-Ju Ho et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation

Joshua Owen et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Herceptin-decorated paclitaxel-loaded poly(lactide-co-glycolide) nanobubbles: ultrasound-facilitated release and targeted accumulation in breast cancers

Shigen Zhong et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2020)

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Review Medicine, General & Internal

An Introduction to High Intensity Focused Ultrasound: Systematic Review on Principles, Devices, and Clinical Applications

Zahra Izadifar et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Nanoscience & Nanotechnology

Magnetic Targeting and Ultrasound Activation of Liposome-Microbubble Conjugate for Enhanced Delivery of Anticancer Therapies

Pankaj Dwivedi et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Oncology

Ultrasound-mediated diagnostic imaging and advanced treatment with multifunctional micro/nanobubbles

Jiaping Li et al.

CANCER LETTERS (2020)

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Article Biotechnology & Applied Microbiology

Enhancement Effect of Microbubble-Enhanced Ultrasound in Microwave Ablation in Rabbit VX2 Liver Tumors

Shuyi Xiao et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

Nigel Bush et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Oncology

CD105 is a prognostic marker and valid endothelial target for microbubble platforms in cholangiocarcinoma

Amit Nair et al.

CELLULAR ONCOLOGY (2020)

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Article Pharmacology & Pharmacy

Increasing Doxorubicin Loading in Lipid-Shelled Perfluoropropane Nanobubbles via a Simple Deprotonation Strategy

Pinunta Nittayacharn et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, General & Internal

Non-Invasive Skin Cancer Diagnosis Using Hyperspectral Imaging for In-Situ Clinical Support

Raquel Leon et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Biochemical Research Methods

Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer

Yi Zhu et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of the Reproducibility of Bolus Transit Quantification With Contrast-Enhanced Ultrasound Across Multiple Scanners and Analysis Software Packages-A Quantitative Imaging Biomarker Alliance Study

Michalakis A. Averkiou et al.

INVESTIGATIVE RADIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Real time ultrasound molecular imaging of prostate cancer with PSMA-targeted nanobubbles

Reshani H. Perera et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Construction of Nucleolin-Targeted Lipid Nanobubbles and Contrast-Enhanced Ultrasound Molecular Imaging in Triple-Negative Breast Cancer

Kejing Fang et al.

PHARMACEUTICAL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Enhanced Cellular Uptake and Gene Silencing Activity of Survivin-siRNA via Ultrasound-Mediated Nanobubbles in Lung Cancer Cells

Hasan Akbaba et al.

PHARMACEUTICAL RESEARCH (2020)

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Article Acoustics

A novel flotation technique combining carrier flotation and cavitation bubbles to enhance separation efficiency of ultra-fine particles

Shaoqi Zhou et al.

ULTRASONICS SONOCHEMISTRY (2020)

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Article Acoustics

INVESTIGATING THE ACCUMULATION OF SUBMICRON PHASE-CHANGE DROPLETS IN TUMORS

Brandon L. Helfield et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

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Article Multidisciplinary Sciences

Non-invasive early detection of cancer four years before conventional diagnosis using a blood test

Xingdong Chen et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures

Matthew D. Bourn et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Effectiveness of Oil-Layered Albumin Microbubbles Produced Using Microfluidic T-Junctions in Series for In Vitro Inhibition of Tumor Cells

Aaqib H. Khan et al.

LANGMUIR (2020)

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Article Biotechnology & Applied Microbiology

Dual-Mode Contrast Agents with RGD-Modified Polymer for Tumour-Targeted US/NIRF Imaging

Zhenhui Nie et al.

ONCOTARGETS AND THERAPY (2020)

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Article Multidisciplinary Sciences

Evaluation of low-intensity pulsed ultrasound on doxorubicin delivery in 2D and 3D cancer cell cultures

Migle Paskeviciute et al.

SCIENTIFIC REPORTS (2020)

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Article Biotechnology & Applied Microbiology

Multifunctional nanobubbles carrying indocyanine green and paclitaxel for molecular imaging and the treatment of prostate cancer

Minmin Lan et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Image-Guided Treatment of Primary Liver Cancer in Mice Leads to Vascular Disruption and Increased Drug Penetration

Sara B. Keller et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

Yoko Endo-Takahashi et al.

PHARMACEUTICS (2020)

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Article Nanoscience & Nanotechnology

Overcoming anticancer resistance by photodynamic therapy-related efflux pump deactivation and ultrasound-mediated improved drug delivery efficiency

Doyeon Kim et al.

NANO CONVERGENCE (2020)

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Article Biotechnology & Applied Microbiology

Tumor Targeted Multifunctional Magnetic Nanobubbles for MR/US Dual Imaging and Focused Ultrasound Triggered Drug Delivery

Zhen Jin et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Novel Span-PEG Multifunctional Ultrasound Contrast Agent Based on CNTs as a Magnetic Targeting Factor and a Drug Carrier

Jie Zhang et al.

ACS OMEGA (2020)

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Article Pharmacology & Pharmacy

Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells

Ragnhild Haugse et al.

PHARMACEUTICS (2020)

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Article Biotechnology & Applied Microbiology

A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy

Ming-Hsien Chan et al.

NANOMEDICINE (2020)

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Article Acoustics

SYNERGISTIC EFFECTS OF PULSED FOCUSED ULTRASOUND AND A DOXORUBICIN-LOADED MICROPARTICLE-MICROBUBBLE COMPLEX IN A PANCREATIC CANCER XENOGRAFT MOUSE MODEL

Hyo-Jin Kang et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

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Article Engineering, Biomedical

Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model

Jonah S. Harmon et al.

APL BIOENGINEERING (2020)

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Article Medicine, Research & Experimental

Opto-acoustic synergistic irradiation for vaporization of natural melanin-cored nanodroplets at safe energy levels and efficient sono-chemo-photothermal cancer therapy

Yaxin Hu et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy

Wen-Tse Huang et al.

THERANOSTICS (2020)

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Article Materials Science, Biomaterials

Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer

Xuechen Qian et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Acoustics

Six-Transmembrane Epithelial Antigen of the Prostate-1 (STEAP-1)-Targeted Ultrasound Imaging Microbubble Improves Detection of Prostate Cancer In Vivo

Yun Yuan et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Pharmacokinetic Modeling of Targeted Ultrasound Contrast Agents for Quantitative Assessment of Anti-Angiogenic Therapy: a Longitudinal Case-Control Study in Colon Cancer

Simona Turco et al.

MOLECULAR IMAGING AND BIOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Lipid nanobubbles as an ultrasound-triggered artesunate delivery system for imaging-guided, tumor-targeted chemotherapy

Shuang Gao et al.

ONCOTARGETS AND THERAPY (2019)

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Article Chemistry, Medicinal

Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles

Pinunta Nittayacharn et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Acoustics

Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model

Lauren J. Delaney et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2019)

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Article Oncology

FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer

Yamei Shen et al.

CANCER LETTERS (2019)

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Article Pharmacology & Pharmacy

Targeted chemo-sonodynamic therapy treatment of breast tumours using ultrasound responsive microbubbles loaded with paclitaxel, doxorubicin and Rose Bengal

Keiran Logan et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Pharmacology & Pharmacy

Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer

Yucel Baspinar et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Engineering, Biomedical

Microneedle-Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound-Assisted Drug Delivery

Ashkan Zandi et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Oncology

Paclitaxel-loaded nanobubble targeted to pro-gastrin-releasing peptide inhibits the growth of small cell lung cancer

Jin-Ping Wang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Pharmacology & Pharmacy

Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

Ragnhild Haugse et al.

PHARMACEUTICS (2019)

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Article Engineering, Biomedical

A multifunctional theranostic contrast agent for ultrasound/near infrared fluorescence imaging-based tumor diagnosis and ultrasound-triggered combined photothermal and gene therapy

Ling Wang et al.

ACTA BIOMATERIALIA (2019)

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Article Nanoscience & Nanotechnology

Biodegradable nanotheranostics with hyperthermia-induced bubble ability for ultrasound imaging-guided chemo-photothermal therapy

Changsong Xu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Biochemical Research Methods

Ultrasound-mediated destruction of vascular endothelial growth factor (VEGF) targeted and paclitaxel loaded microbubbles for inhibition of human breast cancer cell MCF-7 proliferation

Jilian Su et al.

MOLECULAR AND CELLULAR PROBES (2019)

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Article Medicine, Research & Experimental

Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model

Diane Bressand et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Oncology

Ultrasonic Cavitation Ameliorates Antitumor Efficacy of Residual Cancer After Incomplete Radiofrequency Ablation in Rabbit VX2 Liver Tumor Model

Shi-yan Li et al.

TRANSLATIONAL ONCOLOGY (2019)

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Article Acoustics

TIME-INTENSITY-CURVE ANALYSIS AND TUMOR EXTRAVASATION OF NANOBUBBLE ULTRASOUND CONTRAST AGENTS

Hanping Wu et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2019)

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Article Oncology

Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells

Muhammad Saad Khan et al.

CANCERS (2019)

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Article Chemistry, Multidisciplinary

Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach

Ameya Prabhakar et al.

ACS OMEGA (2019)

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Article Nanoscience & Nanotechnology

Preparation Of Nanobubbles Modified With A Small-Molecule CXCR4 Antagonist For Targeted Drug Delivery To Tumors And Enhanced Ultrasound Molecular Imaging

Yanli Peng et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Biotechnology & Applied Microbiology

New FH peptide-modified ultrasonic nanobubbles for delivery of doxorubicin to cancer-associated fibroblasts

Lu Guo et al.

NANOMEDICINE (2019)

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Article Nanoscience & Nanotechnology

A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells

Chunyan Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Nanoscience & Nanotechnology

Biocompatible Chitosan Nanobubbles for Ultrasound-Mediated Targeted Delivery of Doxorubicin

Xiaoying Zhou et al.

NANOSCALE RESEARCH LETTERS (2019)

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Article Nanoscience & Nanotechnology

Cerasome-based gold-nanoshell encapsulating L-menthol for ultrasound contrast imaging and photothermal therapy of cancer

Qingqing Guan et al.

NANOTECHNOLOGY (2019)

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Review Nanoscience & Nanotechnology

Nano-lipospheres as acoustically active ultrasound contrast agents: evolving tumor imaging and therapy technique

Laura Emma Andrews et al.

NANOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Tumour targeted contrast enhanced ultrasound imaging dual-modal microbubbles for diagnosis and treatment of triple negative breast cancer

Min Bai et al.

RSC ADVANCES (2019)

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Article Medicine, Research & Experimental

Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound

Yi-Ju Ho et al.

THERANOSTICS (2019)

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Article Medicine, Research & Experimental

Ultrasound-mediated cavitation enhances the delivery of an EGFR-targeting liposomal formulation designed for chemo-radionuclide therapy

Eloise Thomas et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

New Polylactic Acid Multifunctional Ultrasound Contrast Agent Based on Graphene Oxide as the Carrier of Targeted Factor and Drug Delivery

Jie Zhang et al.

ACS OMEGA (2019)

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Article Chemistry, Multidisciplinary

Enhanced ultrasound imaging and anti-tumor in vivo properties of Span-polyethylene glycol with folic acid-carbon nanotube-paclitaxel multifunctional microbubbles

Jie Zhang et al.

RSC ADVANCES (2019)

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Article Nanoscience & Nanotechnology

In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy

Hailin Tang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Size-Modulable Nanoprobe for High-Performance Ultrasound Imaging and Drug Delivery against Cancer

Lu Zhang et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer

Min Chen et al.

ACS NANO (2018)

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Article Engineering, Biomedical

Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer

Ranran Zhao et al.

BIOMATERIALS (2018)

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Article Oncology

Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma

Lotfi Abou-Elkacem et al.

CLINICAL CANCER RESEARCH (2018)

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Article Engineering, Biomedical

Manipulating multifaceted microbubble shell composition to target both TRAIL-sensitive and resistant cells

Lauren J. Jablonowski et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Article Chemistry, Multidisciplinary

Annexin V conjugated nanobubbles: A novel ultrasound contrast agent for in vivo assessment of the apoptotic response in cancer therapy

Tian Zhou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Longitudinal assessment of ultrasound-guided complementary microRNA therapy of hepatocellular carcinoma

Sayan Mullick Chowdhury et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Combination of chemotherapy and photodynamic therapy for cancer treatment with sonoporation effects

Hohyeon Lee et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Medicine, Research & Experimental

Ultrasound-guided intertumoral injection of contrast agents combined with human p53 gene for the treatment of breast cancer

Jun-Cheng Guo et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2018)

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Article Chemistry, Multidisciplinary

Nanobubble-embedded inorganic 808 nm excited upconversion nanocomposites for tumor multiple imaging and treatment

Ming-Hsien Chan et al.

CHEMICAL SCIENCE (2018)

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Article Multidisciplinary Sciences

Preparation and Imaging Investigation of Dual-targeted C3F8-filled PLGA Nanobubbles as a Novel Ultrasound Contrast Agent for Breast Cancer

Jing Du et al.

SCIENTIFIC REPORTS (2018)

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Article Medicine, Research & Experimental

Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound-controlled In Situ Accumulation

Yujia You et al.

THERANOSTICS (2018)

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Article Multidisciplinary Sciences

SPIO labeling of endothelial cells using ultrasound and targeted microbubbles at diagnostic pressures

Ilya Skachkov et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption

Costas D. Arvanitis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Acoustics

OPTIMIZATION OF PHASE-CHANGE CONTRAST AGENTS FOR TARGETING MDA-MB-231 BREAST CANCER CELLS

Kyle P. Hadinger et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2018)

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Article Multidisciplinary Sciences

Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery

Rajeet Chandan et al.

SCIENTIFIC REPORTS (2018)

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Review Oncology

Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases

Ying Meng et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

An ultrasound-responsive dual-modal US/T-1-MRI contrast agent for potential diagnosis of prostate cancer

Young Il Yoon et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Enhanced pre-operative axillary staging using intradermal microbubbles and contrast-enhanced ultrasound to detect and biopsy sentinel lymph nodes in breast cancer: a potential replacement for axillary surgery

Karina Cox et al.

BRITISH JOURNAL OF RADIOLOGY (2018)

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Article Multidisciplinary Sciences

Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation

Zsofia I. Kovacs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Pharmacology & Pharmacy

Bubble-generating nano-lipid carriers for ultrasound/CT imaging-guided efficient tumor therapy

Nan Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Physical

Structural regulation of self-assembled iron oxide/polymer microbubbles towards performance-tunable magnetic resonance/ultrasonic dual imaging agents

Heze Guo et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2016)

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Article Medicine, Research & Experimental

CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation

Kun Zhang et al.

THERANOSTICS (2015)

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Article Pharmacology & Pharmacy

Enhancement of Blood-Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

Yoichi Negishi et al.

PHARMACEUTICS (2015)

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Article Chemistry, Multidisciplinary

A Multitheragnostic Nanobubble System to Induce Blood-Brain Barrier Disruption with Magnetically Guided Focused Ultrasound

Hsin-Yang Huang et al.

ADVANCED MATERIALS (2015)

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Article Engineering, Biomedical

Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes

Tinghui Yin et al.

BIOMATERIALS (2014)

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Article Oncology

Temporary Disruption of the Blood-Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

Nathan McDannold et al.

CANCER RESEARCH (2012)

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Article Multidisciplinary Sciences

Ultrasound-Induced New Cellular Mechanism Involved in Drug Resistance

Mariame A. Hassan et al.

PLOS ONE (2012)

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Article Engineering, Biomedical

Study of a novel ultrasonically triggered drug vehicle with magnetic resonance properties

Tse-Ying Liu et al.

ACTA BIOMATERIALIA (2011)

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Article Materials Science, Characterization & Testing

Post-processing of the full matrix of ultrasonic transmit-receive array data for non-destructive evaluation

C Holmes et al.

NDT & E INTERNATIONAL (2005)

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