期刊
PHARMACEUTICS
卷 14, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14071458
关键词
ultrasmall Gd2O3 nanoparticle; folic acid; cRGD; multiple tumor-targeting ligand; tumor imaging; blood circulation enhancement
资金
- Basic Science Research Program of the National Research Foundation (NRF) - Ministry of Education, Science, and Technology [2016R1D1A3B01007622]
- Korean government (Ministry of Science, and Information and Communications Technology: MSIT) [2021R1A4A1029433]
Hydrophilic and biocompatible PAA-coated ultrasmall Gd2O3 nanoparticles were synthesized and conjugated with tumor-targeting ligands. The nanoparticles were successfully used for tumor imaging, showing higher contrasts at the tumor site and prolonged circulation in the blood.
Hydrophilic and biocompatible PAA-coated ultrasmall Gd2O3 nanoparticles (d(avg) = 1.7 nm) were synthesized and conjugated with tumor-targeting ligands, i.e., cyclic arginylglycylaspartic acid (cRGD) and/or folic acid (FA). FA-PAA-Gd2O3 and cRGD/FA-PAA-Gd2O3 nanoparticles were successfully applied in U87MG tumor-bearing mice for tumor imaging using T-1 magnetic resonance imaging (MRI). cRGD/FA-PAA-Gd2O3 nanoparticles with multiple tumor-targeting ligands exhibited higher contrasts at the tumor site than FA-PAA-Gd2O3 nanoparticles with mono tumor-targeting ligands. In addition, the cRGD/FA-PAA-Gd2O3 nanoparticles exhibited higher contrasts in all organs, especially the aorta, compared with those of the FA-PAA-Gd2O3 nanoparticles, because of the blood cell hitchhiking effect of cRGD in the cRGD/FA-PAA-Gd2O3 nanoparticles, which prolonged their circulation in the blood.
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