☆ 4.7 Review

New Advances in Biomedical Application of Polymeric Micelles

PHARMACEUTICS (2022)

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Nanotechnology Applications in Plant Tissue Culture and Molecular Genetics: A Holistic Approach

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Summary: Nanotechnology has been applied in agriculture in the past decade, contributing to increased agricultural production and food security. The use of nanoparticles in plant biotechnology has demonstrated positive effects on plant growth and development, enhancing processes such as micropropagation and genetic transformation. More research is needed to understand the mechanisms of nanoparticle delivery and translocation in plants to ensure the safe and effective application of nanotechnology in plant biotechnology.

CURRENT NANOSCIENCE (2022)

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Review Pharmacology & Pharmacy

Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

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Summary: Polymeric micelles (PMs) are unique carriers for targeted delivery and enhancement of the bioavailability of chemotherapeutics. They have the potential to encapsulate multiple therapeutic molecules and can be used for drug therapy and tumor imaging. However, there are some limitations associated with the translation of PMs from the laboratory to clinics.

DRUG DISCOVERY TODAY (2022)

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Article Chemistry, Multidisciplinary

Drug-Dependent Morphological Transitions in Spherical and Worm-Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs

Chaemin Lim et al.

Summary: The study found that the morphology of polymeric micelles significantly affects pharmacological efficacy, with spherical micelles accumulating rapidly in tumor tissue while retaining large amounts of drug, and worm-like micelles accumulating more slowly and only upon releasing significant amounts of drug.

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Article Engineering, Biomedical

Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

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Summary: This review discusses strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy. Optimizing the intrinsic physicochemical properties and external modification are key methods.

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Review Pharmacology & Pharmacy

Nanomedicine for brain cancer

Sabina Quader et al.

Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.

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Review Oncology

Nanotechnology-aided advancement in the combating of cancer metastasis

Leela Rani Avula et al.

Summary: This article discusses the potential improvements that nanotechnology-aided approaches can bring to the identification and treatment of metastatic cancer, either alone or in combination with existing conventional techniques. By linking specific nanotechnology-aided strategies to the complex biology of the metastatic cascade, new avenues for targeted treatment and development of anti-metastatic agents are opened up. The article also presents a viewpoint on the progress of translation of nanotechnology into cancer metastasis patient care.

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Review Biochemistry & Molecular Biology

Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology

Andrew M. Hersh et al.

Summary: This article provides a review of the potential of nanoparticles (NPs) in improving drug delivery to brain tumors. The unique physical and chemical properties of NPs and the mechanisms of NP transport across the blood-brain barrier are discussed, along with the major types of NPs investigated for brain tumor treatment. In addition, the use of NPs as imaging contrast agents and their conjugation with imaging probes for visualization and treatment monitoring are explored. Finally, the limitations of NPs for brain tumor treatment are discussed.

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Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

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Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.

ACS NANO (2022)

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Review Polymer Science

A Review of Polymeric Micelles and Their Applications

Suguna Perumal et al.

Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.

POLYMERS (2022)

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Review Biochemistry & Molecular Biology

Therapeutic peptides: current applications and future directions

Lei Wang et al.

Summary: Peptide drug development has achieved significant progress in the past decade, thanks to new production, modification, and analytic technologies. These advancements have addressed the inherent limitations of peptides and have resulted in achievements in various therapeutic areas.

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Review Chemistry, Multidisciplinary

Cell Membrane-Coated Mimics: A Methodological Approach for Fabrication, Characterization for Therapeutic Applications, and Challenges for Clinical Translation

Vaishali Chugh et al.

Summary: Cell membrane-coated (CMC) mimics are micro/nanosystems that mimic the functions of cells by combining isolated cell membranes with chosen templates. They possess excellent biological compatibility and tunability, making them valuable for therapeutic applications. This review discusses the recent advances in the development of CMC mimics, emphasizing on their components, fabrication methods, and challenges in clinical translation.

ACS NANO (2021)

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Bioequivalence assessment of high-capacity polymeric micelle nanoformulation of paclitaxel and Abraxane® in rodent and non-human primate models using a stable isotope tracer assay

Duhyeong Hwang et al.

Summary: The in vivo fate of nanoformulated drugs is influenced by the physicochemical properties of the drug and the functionality of nanocarriers; a thorough understanding of the pharmacokinetic characteristics of nanoformulations is essential for elucidating the mechanisms of nanomedicine-driven changes in drug exposure and PK/PD relationships. The study evaluated the bioequivalence of POXOL hl-PM to Abraxane (R) and found comparable plasma PK profiles for total PTX and distinct drug fractions in animal models, showcasing the reliability of NCL studies for assessing nanoformulations prior to clinical investigation.

BIOMATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Highly Efficient Modular Construction of Functional Drug Delivery Platform Based on Amphiphilic Biodegradable Polymers via Click Chemistry

Guangkuo Zhao et al.

Summary: A general method for efficient preparation of functional biodegradable PEG-polyester copolymers via click chemistry has been developed. The resulting amphiphilic copolymers demonstrate excellent biodegradability and low cytotoxicity, and can self-assemble into nanoparticles in aqueous media. This work paves the way for further applications of functional PEG-polyesters as drug delivery materials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Blood-Brain Barrier in Brain Tumors: Biology and Clinical Relevance

Francesca Mo et al.

Summary: The presence of barriers like the BBB and BTB make it difficult for antineoplastic drugs to penetrate the brain, but various techniques and molecular strategies have been developed to overcome these limitations, showing promising results in clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Pluronic stabilized conjugated polymer nanoparticles for NIR fluorescence imaging and dual phototherapy applications

Timea Nagy-Simon et al.

Summary: This study introduces a novel method for preparing NIR-activatable therapeutic nanoparticles using PCPDTBT conjugated polymer. By encapsulating with a Pluronic layer, the nanoparticles not only improve hydrophobicity, but also enhance the photothermal conversion efficiency and singlet oxygen generation in aqueous dispersion.

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Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

Samrat Mazumdar et al.

Summary: The beneficial or deleterious effects of nanomedicines are influenced by their complex interactions with intracellular pathways and their subcellular fate. Manipulating the physicochemical attributes of nanocarriers can direct nanoparticles towards specific sub-cellular organelles, affecting cellular internalization and enhancing intracellular uptake via specific endocytic pathways.

ACTA PHARMACEUTICA SINICA B (2021)

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Polymeric Micelles: A Promising Pathway for Dermal Drug Delivery

Ana Parra et al.

Summary: Polymeric micelles in nanotechnology have many advantages in cutaneous application, such as increased bioavailability of drugs, greater efficacy even at lower doses, and selective drug delivery in specific organelles, while reducing many adverse effects, which can help improve patient compliance with treatment.

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Review Biotechnology & Applied Microbiology

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Michele Schlich et al.

Summary: Ionizable lipid nanoparticles (LNPs) are the most advanced nano-delivery system for therapeutic nucleic acids, with the development of ionizable lipids playing a key role in their success. Overcoming challenges in RNA delivery, such as endosomal escape, is crucial for ensuring the therapeutic activity of RNA molecules. Understanding the mechanisms of endosomal escape and improving cytosolic delivery are important for developing future LNPs with enhanced nucleic acid delivery capabilities.

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Self-assembly of protein-polymer conjugates for drug delivery

Corey. A. Stevens et al.

Summary: Protein-polymer conjugates combine the stability of polymers with the diversity, specificity, and functionality of biomolecules, resulting in hybrid materials with unique properties for drug delivery applications. Engineering amphiphilicity into these bioconjugate materials can lead to phase separation and assembly of high-order structures, with multiple levels of organization and emergence of new properties at each level influenced by lower levels.

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Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M. Ghezzi et al.

Summary: Polymeric micelles, innovative aggregation colloids formed by self-assembling of amphiphilic polymers in solution, offer advantages in drug administration but also face challenges such as lower stability and complex characterization. Understanding their interaction with the biological environment is crucial, and a combination of different characterization techniques can provide a deeper insight into their in vivo behavior.

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Review Chemistry, Multidisciplinary

Polymeric micelles in cancer therapy: State of the art

Balaram Ghosh et al.

Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma

Tao Yang et al.

Summary: Monoclonal antibodies conjugated with multiple polymer chains, functionalized to target glucose transporter 1 and detaching in the reductive tumor microenvironment, can enhance the potency and safety of checkpoint blockade therapy for glioblastoma. This approach showed promising results in mouse models, reinvigorating antitumor immune responses and inducing protective immunological memory against tumor rechallenge.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Materials Science, Biomaterials

Amphiphilic copolymers in biomedical applications: Synthesis routes and property control

Francesca Perin et al.

Summary: The demand for new materials in precision and patient-specific medicine has driven the synthesis of complex block copolymers. Amphiphilic block copolymers show great potential in biomedical applications due to their stimuli responsiveness, drug loading capabilities, and reversible thermal gelation. Techniques for synthesizing and fine-tuning the properties of these materials are discussed, highlighting their promising future in medicine.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Ozlem Sen et al.

Summary: This review examines the use of nanomaterials in the detection and treatment of cancer metastasis, focusing on the impact of nanostructures on cell migration, invasion, and angiogenesis in the tumor microenvironment.

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Article Biotechnology & Applied Microbiology

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Caio H. N. Barros et al.

Summary: Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with intrinsic antibacterial activity, showing enhanced penetration into biofilms and improved antibacterial activity compared to free curcumin. These nanoparticles are also efficient at disrupting mature biofilms and inhibiting bacterial growth within biofilms, suggesting their potential for drug delivery applications.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

Bispecific Antibodies: From Research to Clinical Application

Jiabing Ma et al.

Summary: Bispecific antibodies (BsAbs) have two binding sites directed at different antigens or epitopes, and their clinical therapeutic effects are superior to monoclonal antibodies (MoAbs), used in tumor immunotherapy and other disease treatments. Over 30 mature commercial technology platforms have been utilized to generate and develop BsAbs based on heterologous recombination of heavy chains and light chains, with three BsAbs receiving market approval.

FRONTIERS IN IMMUNOLOGY (2021)

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Mixed Pluronic-Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics-The Influence on the Antibacterial Activity

Maria Antonia Tanase et al.

Summary: Novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were studied as drug delivery systems for Norfloxacin. The optimal molar ratio of surfactants was determined to prepare carriers with minimal surfactant concentrations. The mixed micelles showed tunable extended release of Norfloxacin and good activity against clinical isolated strains, while some cytotoxicity was found at high concentrations.

PHARMACEUTICS (2021)

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Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers

Julian D. Torres-Vanegas et al.

Summary: This review highlights the potential of gene therapy in addressing genetic diseases and the use of non-viral systems, specifically nanoparticles, for efficient delivery of therapeutic cargoes. Researchers have focused on overcoming biological barriers and enhancing cellular internalization to achieve successful cargo delivery. The diversity of nanocarriers and recent advances in strategies for cargo delivery are discussed to improve the effectiveness of gene therapy.

PHARMACEUTICS (2021)

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Article Biophysics

Folate-targeted Pluronic-chitosan nanocapsules loaded with IR780 for near-infrared fluorescence imaging and photothermal-photodynamic therapy of ovarian cancer

Monica Potara et al.

Summary: In this study, a nanotherapeutic platform integrating NIR imaging with photodynamic and photothermal therapies against ovarian cancer was developed. Utilizing IR780 iodide in a polymeric nanoformulation allowed for the construction of a multifunctional nanosystem with fluorescence, singlet oxygen generation, and heating capabilities for imaging-assisted phototherapy. The targeted nanocapsules showed improved therapeutic performance against ovarian cancer cells, demonstrating their potential as theranostic agents for image-guided dual PDT-PTT and imaging-assisted surgery.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Biochemistry & Molecular Biology

Peptide-Assisted Nucleic Acid Delivery Systems on the Rise

Shabnam Tarvirdipour et al.

Summary: Peptides play a crucial role in advancing gene delivery systems in nanomedicine. They assist in ferrying nucleic acids to their target sites efficiently and overcoming membrane barriers encountered on the way.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Polymeric micelle formulations for the cutaneous delivery of sirolimus: A new approach for the treatment of facial angiofibromas in tuberous sclerosis complex

Julie Quartier et al.

Summary: This study successfully developed aqueous formulations of sirolimus loaded in polymeric micelles for targeted epidermal delivery, which increased cutaneous bioavailability without transdermal permeation. The cutaneous biodistribution method provided detailed insight into drug bioavailability in different skin compartments, complementing and explaining clinical observations of formulation efficacy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Jialin Yu et al.

Summary: Pluronic polymers, comprised of hydrophobic PPO and hydrophilic PEO arranged in a triblock structure, are widely utilized in pharmaceutical applications, particularly in tumor therapy. By forming nano carriers through self-assembly or in combination with other materials, Pluronics offer a versatile platform for designing multifunctional drug carriers.

MOLECULES (2021)

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Unravelling cytosolic delivery of cell penetrating peptides with a quantitative endosomal escape assay

Serena L. Y. Teo et al.

Summary: Current understanding of cytosolic delivery mechanisms is limited due to conflicting reports and limited sensitivity in existing methods. The authors developed a highly sensitive SLEEQ assay and found that positively charged CPPs enhance cytosolic delivery through increased non-specific cell membrane association, rather than increased endosomal escape efficiency.

NATURE COMMUNICATIONS (2021)

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PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

Naoto Yoshinaga et al.

Summary: This study suggests a cation-free mRNA delivery strategy by hybridization of PEGylated RNA oligonucleotides with mRNA, which improves mRNA nuclease stability and protein expression efficiency significantly.

PHARMACEUTICS (2021)

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Poly(α-L-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

Maochao Zheng et al.

Summary: Poly(alpha-L-lysine) (PLL) is a water-soluble, cationic biopolymer composed of alpha-L-lysine structural units. Over the past decade, significant progress has been made in the synthesis and biomedical applications of PLL, including antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. Despite the promising potential of PLL-based nanomaterials in biomedical fields, challenges and perspectives still need to be addressed.

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Peisen Zhang et al.

Summary: Nanotechnology shows promising potential in improving immunotherapeutic outcomes for patients with metastatic cancer by selectively triggering specific tumoricidal effects, enhancing immune cell access to major sites of metastasis, and inducing a persistent immune response.

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THERANOSTICS (2021)

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PHARMACEUTICS (2020)

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Ferran Nadal-Bufi et al.

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Ashutosh Barve et al.

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Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

Duhyeong Hwang et al.

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Article Multidisciplinary Sciences

Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Anna Galstyan et al.

NATURE COMMUNICATIONS (2019)

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Review Biotechnology & Applied Microbiology

Nanotechnology based therapeutic application in cancer diagnosis and therapy

Ragini Singh

3 BIOTECH (2019)

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Review Biochemical Research Methods

Overcoming Endosomal Entrapment in Drug Delivery

Dehua Pei et al.

BIOCONJUGATE CHEMISTRY (2019)

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Review Chemistry, Medicinal

Immunogenicity of Protein Pharmaceuticals

Robert Dingman et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Oncology

Patterns of Tumor Progression Predict Small and Tissue-Specific Tumor-Originating Niches

Thomas Buder et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Chemistry, Multidisciplinary

Dynamics of amphiphilic block copolymers in an aqueous solution: direct imaging of micelle formation and nanoparticle encapsulation

Chang Li et al.

NANOSCALE (2019)

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Review Immunology

Cold Tumors: A Therapeutic Challenge for Immunotherapy

Paola Bonaventura et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Synthetic Polymeric Mixed Micelles Targeting Lymph Nodes Trigger Enhanced Cellular and Humoral Immune Responses

Chenxi Li et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Drug Combination Synergy in Worm-like Polymeric Micelles Improves Treatment Outcome for Small Cell and Non-Small Cell Lung Cancer

Xiaomeng Wan et al.

ACS NANO (2018)

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Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

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Article Pharmacology & Pharmacy

Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery

Wessam H. Abd-Elsalam et al.

DRUG DELIVERY (2018)

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Article Biochemistry & Molecular Biology

Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy

Salma M. Abdel-Hafez et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Pharmacology & Pharmacy

The development of stimuli-responsive polymeric micelles for effective delivery of chemotherapeutic agents

Yimu Li et al.

JOURNAL OF DRUG TARGETING (2018)

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Article Engineering, Biomedical

Polyphenol-Poloxamer Self-Assembled Supramolecular Nanoparticles for Tumor NIRF/PET Imaging

Xinyu Wang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Review Chemistry, Physical

Strategies to improve micelle stability for drug delivery

Yang Lu et al.

NANO RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers

Somnath G. Kandekar et al.

NANOSCALE (2018)

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Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Review Pharmacology & Pharmacy

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

Mikhail Durymanov et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Oncology

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

Nemany A. N. Hanafy et al.

CANCERS (2018)

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Article Pharmacology & Pharmacy

Improvement of the skin penetration of hydrophobic drugs by polymeric micelles

Kensuke Yotsumoto et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Review Oncology

A Critical Overview of Targeted Therapies for Glioblastoma

Kewal K. Jain

FRONTIERS IN ONCOLOGY (2018)

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Review Pharmacology & Pharmacy

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Behzad Sharif Makhmalzade et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2018)

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Review Pharmacology & Pharmacy

Polymeric mixed micelles as nanomedicines: Achievements and perspectives

Maximiliano Cagel et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Review Nanoscience & Nanotechnology

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Fakhar Ud Din et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Chemistry, Multidisciplinary

Strategies for improving the payload of small molecular drugs in polymeric micelles

Yu Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Polymer Science

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

Mauro Almeida et al.

JOURNAL OF POLYMER RESEARCH (2017)

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Review Biotechnology & Applied Microbiology

Intracellular delivery of proteins by nanocarriers

Moumita Ray et al.

NANOMEDICINE (2017)

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Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

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Review Biophysics

Cell targeting peptides as smart ligands for targeting of therapeutic or diagnostic agents: a systematic review

Ali Mousavizadeh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Pharmacology & Pharmacy

Potential enhancement and targeting strategies of polymeric and lipid-based nanocarriers in dermal drug delivery

Emine Kahraman et al.

THERAPEUTIC DELIVERY (2017)

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Review Chemistry, Multidisciplinary

Getting Drugs Across Biological Barriers

Rong Yang et al.

ADVANCED MATERIALS (2017)

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Article Chemistry, Multidisciplinary

When self-assembly meets topology: an enhanced micelle stability

Xiaopeng Dong et al.

CHEMICAL COMMUNICATIONS (2017)

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Article Chemistry, Applied

Hyaluronan polymeric micelles for topical drug delivery

Daniela Smejkalova et al.

CARBOHYDRATE POLYMERS (2017)

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Article Biochemistry & Molecular Biology

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance

Steven K. Jones et al.

BIOMACROMOLECULES (2016)

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Review Medicine, Research & Experimental

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

Jay Tibbitts et al.

MABS (2016)

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Review Chemistry, Multidisciplinary

Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs

Avinash Gothwal et al.

PHARMACEUTICAL RESEARCH (2016)

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Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Biochemistry & Molecular Biology

Intracellular Delivery of Charge-Converted Monoclonal Antibodies by Combinatorial Design of Block/Homo Polyion Complex Micelles

Ahram Kim et al.

BIOMACROMOLECULES (2016)

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Article Biophysics

Polymeric micellar nanocarriers of benzoyl peroxide as potential follicular targeting approach for acne treatment

Emine Kahraman et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Biochemistry & Molecular Biology

Biodegradable Stimuli-Responsive Polymeric Micelles for Treatment of Malignancy

Lesan Yan et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

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Review Pharmacology & Pharmacy

Amphiphilic block copolymers-based mixed micelles for noninvasive drug delivery

Hongyan Xu et al.

DRUG DELIVERY (2016)

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Article Materials Science, Biomaterials

F-127-PEI co-delivering docetaxel and TFPI-2 plasmid for nasopharyngeal cancer therapy

Tao Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Review Biotechnology & Applied Microbiology

Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis

Inmaculada Posadas et al.

NANOMEDICINE (2016)

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Article Multidisciplinary Sciences

Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy

Chun-ge Zhang et al.

SCIENTIFIC REPORTS (2016)

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Review Pharmacology & Pharmacy

Nanocarrier-based co-delivery of small molecules and siRNA/miRNA for treatment of cancer

Deepak Chitkara et al.

THERAPEUTIC DELIVERY (2016)

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Review Pharmacology & Pharmacy

Recent advances in amphiphilic polymers for simultaneous delivery of hydrophobic and hydrophilic drugs

Chloe Martin et al.

THERAPEUTIC DELIVERY (2016)

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Article Pharmacology & Pharmacy

Novel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and Characterization

Jungeun Bae et al.

AAPS JOURNAL (2015)

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Article Oncology

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Laura Jeanbart et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

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Article Chemistry, Multidisciplinary

Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors

Kouichi Shiraishi et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s

Anita Schulz et al.

ACS NANO (2014)

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Article Engineering, Biomedical

Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma

Xiaomin Qian et al.

BIOMATERIALS (2014)

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Article Pharmacology & Pharmacy

Investigation of a nanosuspension stabilized by Soluplus® to improve bioavailability

Hua Yang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Review Pharmacology & Pharmacy

Polymeric micelles as drug carriers: their lights and shadows

Masayuki Yokoyama

JOURNAL OF DRUG TARGETING (2014)

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Article Medicine, Research & Experimental

Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

Maria Lapteva et al.

MOLECULAR PHARMACEUTICS (2014)

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Article Chemistry, Multidisciplinary

Disulfide Bond Bridge Insertion Turns Hydrophobic Anticancer Prodrugs into Self-Assembled Nanomedicines

Yongjun Wang et al.

NANO LETTERS (2014)

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Article Chemistry, Multidisciplinary

Multifunctional Tumor-Targeting Nanocarriers Based on Hyaluronic Acid-Mediated and pH-Sensitive Properties for Efficient Delivery of Docetaxel

Shuangshuang Song et al.

PHARMACEUTICAL RESEARCH (2014)

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Review Polymer Science

Pluronic (R) block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances

Anais Pitto-Barry et al.

POLYMER CHEMISTRY (2014)

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Review Chemistry, Multidisciplinary

Polymeric micelles as drug delivery vehicles

Zaheer Ahmad et al.

RSC ADVANCES (2014)

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Review Pharmacology & Pharmacy

Polymer therapeutics-prospects for 21st century: The end of the beginning

Ruth Duncan et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Pharmacology & Pharmacy

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Ying Lu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Chemistry, Multidisciplinary

pH-responsive and charge shielded cationic micelle of poly(L-histidine)-block-short branched PEI for acidic cancer treatment

Jun Hu et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Multidisciplinary

Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy

Guang Hui Gao et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Physical

Determination of critical micelle concentration of polybutadiene-block-poly(ethyleneoxide) diblock copolymer by fluorescence spectroscopy and dynamic light scattering

Onder Topel et al.

JOURNAL OF MOLECULAR LIQUIDS (2013)

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Article Cell Biology

Exploiting Endocytosis for Nanomedicines

Akin Akinc et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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Review Pharmacology & Pharmacy

pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery

Yanhua Liu et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Pharmacology & Pharmacy

Polymeric Micelles of PEG-PE as Carriers of All-Trans Retinoic Acid for Stability Improvement

Angkana Wichit et al.

AAPS PHARMSCITECH (2012)

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Review Pharmacology & Pharmacy

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

Arnaud E. Felber et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Engineering, Biomedical

The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles

Chuan Yang et al.

BIOMATERIALS (2012)

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Review Chemistry, Multidisciplinary

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

Kanjiro Miyata et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Review Chemistry, Multidisciplinary

Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Chao Deng et al.

NANO TODAY (2012)

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Review Polymer Science

Polymeric micelles: authoritative aspects for drug delivery

Sushant S. Kulthe et al.

DESIGNED MONOMERS AND POLYMERS (2012)

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Review Pharmacology & Pharmacy

PEO-PPO Block Copolymers for Passive Micellar Targeting and Overcoming Multidrug Resistance in Cancer Therapy

C. Alvarez-Lorenzo et al.

CURRENT DRUG TARGETS (2011)

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Review Chemistry, Physical

Mixed micelles self-assembled from block copolymers for drug delivery

Amalina Bte Ebrahim Attia et al.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2011)

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Article Oncology

A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

Juan W. Valle et al.

INVESTIGATIONAL NEW DRUGS (2011)

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Article Chemistry, Multidisciplinary

Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles

Yuichi Ohya et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Chemistry, Multidisciplinary

Novel micelle formulations to increase cutaneous bioavailability of azole antifungals

Y. G. Bachhav et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Nanoscience & Nanotechnology

Synergistic encapsulation of the anti-HIV agent efavirenz within mixed poloxamine/poloxamer polymeric micelles

Diego A. Chiappetta et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

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Article Chemistry, Applied

Polymeric micelles for nano-scale drug delivery

Kanjiro Miyata et al.

REACTIVE & FUNCTIONAL POLYMERS (2011)

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Article Oncology

Assessment of the Evolution of Cancer Treatment Therapies

Manuel Arruebo et al.

Cancers (2011)

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Article Engineering, Biomedical

Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

Marina Talelli et al.

BIOMATERIALS (2010)

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Review Biochemistry & Molecular Biology

Endosome-Disruptive Peptides for Improving Cytosolic Delivery of Bioactive Macromolecules

Ikuhiko Nakase et al.

BIOPOLYMERS (2010)

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Review Pharmacology & Pharmacy

Polymeric micelles as a new drug carrier system and their required considerations for clinical trials

Masayuki Yokoyama

EXPERT OPINION ON DRUG DELIVERY (2010)

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Article Medicine, Research & Experimental

Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity

Tao Wang et al.

MOLECULAR PHARMACEUTICS (2010)

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Review Pharmacology & Pharmacy

Challenges and opportunities in dermal/transdermal delivery

Kalpana S. Paudel et al.

THERAPEUTIC DELIVERY (2010)

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Article Biochemical Research Methods

Different Internalization Pathways of Polymeric Micelles and Unimers and Their Effects on Vesicular Transport

Gaurav Sahay et al.

BIOCONJUGATE CHEMISTRY (2008)

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Article Medicine, Research & Experimental

PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release:: Cyclosporin A as an example

Diana Velluto et al.

MOLECULAR PHARMACEUTICS (2008)

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Article Polymer Science

Facile preparation of core-crosslinked micelles from azide-containing thermoresponsive double hydrophilic diblock copolymer via click chemistry

Xiaoze Jiang et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2008)

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Review Pharmacology & Pharmacy

Polymeric micelles for drug targeting

Abdullah Mahmud et al.

JOURNAL OF DRUG TARGETING (2007)

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Article Computer Science, Interdisciplinary Applications

Identifying creative research accomplishments: Methodology and results for nanotechnology and human genetics

Thomas Heinze et al.

SCIENTOMETRICS (2007)

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Article Polymer Science

RAFT synthesis of a thermally responsive ABC triblock copolymer incorporating N-acryloxysuccinimide for facile in situ formation of shell cross-linked micelles in aqueous media

YT Li et al.

MACROMOLECULES (2006)

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Article Engineering, Biomedical

Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone

Y Zhang et al.

BIOMATERIALS (2005)

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Article Chemistry, Multidisciplinary

Polymer micelle with cross-linked ionic core

TK Bronich et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

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Article Thermodynamics

Thermodynamic modelling of the effect of pH upon aggregation transitions in aqueous solutions of the poloxamine, T701

JF Dong et al.

THERMOCHIMICA ACTA (2004)

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Article Chemistry, Multidisciplinary

A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers

E Fournier et al.

PHARMACEUTICAL RESEARCH (2004)

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Article Biophysics

Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers

K Letchford et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2004)

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Article Chemistry, Multidisciplinary

Polymer vesicles in vivo: correlations with PEG molecular weight

PJ Photos et al.

JOURNAL OF CONTROLLED RELEASE (2003)

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Article Chemistry, Multidisciplinary

Stability and release performance of a series of pegylated copolymeric micelles

WJ Lin et al.

PHARMACEUTICAL RESEARCH (2003)

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Article Chemistry, Multidisciplinary

Determination of critical micelle concentration by hyper-Rayleigh scattering

S Ghosh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

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Article Chemistry, Medicinal

Intracellular uptake and trafficking of pluronic micelles in drug-sensitive and MDR cells: Effect on the intracellular drug localization

N Rapoport et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2002)

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Review Pharmacology & Pharmacy

Practical aspects of lyophilization using non-aqueous co-solvent systems

DL Teagarden et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2002)

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Review Chemistry, Multidisciplinary

Structure and design of polymeric surfactant-based drug delivery systems

VP Torchilin

JOURNAL OF CONTROLLED RELEASE (2001)

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