4.7 Article

Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

期刊

PHARMACEUTICS
卷 14, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics14071350

关键词

thyme oil multilayer nanoemulsions; release kinetics; transdermal delivery; anti-inflammatory; anti-melanoma

资金

  1. King Khalid University [RGP.2/161/43]

向作者/读者索取更多资源

This study analyzed the chemical composition of Thymus vulgaris L. (thyme) essential oil (TEO) and investigated the impact of a protective layer of amphiphilic oligochitosan (AOC) on the stability and transdermal potential of TEO multilayer nanoemulsions. The AOC layer improved the stability of TEO-based nanoemulsions and enhanced their anti-inflammatory, transdermal, and anti-melanoma effects.
(1) Background: Thymus vulgaris L. (thyme) essential oil (TEO) has gained much attention because of its long history of medicinal usage. However, the lack of precise chemical profiling of the TEO and methods to optimize the bioactivity and delivery of its constituents has hampered its research on quality control and biological function; (2) Methods: The current study aimed to analyze the TEO's chemical composition using the GC-MS method and identify its key components. Another objective of this work is to study the impact of the protective layer of amphiphilic oligochitosan (AOC) on the physicochemical stability and transdermal potentials of TEO multilayer nanoemulsions formulated by the incorporation of TEO, Tween80, lecithin (Lec), and AOC; (3) Results: The AOC protective layer significantly improved the stability of TEO-based NEs as revealed by the constancy of their physicochemical properties (particle size and zeta potential) during storage for a week. Excessive fine-tuning of thyme extract NEs and the AOC protective layer's persistent positive charge have been contributed to the thyme extract's improved anti-inflammatory, transdermal, and anti-melanoma potentials; (4) Conclusions: the AOC-coated NEs could offer novel multifunctional nanoplatforms for effective transdermal delivery of lipophilic bioactive materials.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据