4.4 Review

Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles

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Summary: Stem cell therapy using magnetic scaffolds has been developed to treat osteoarthritis. The magnetic scaffolds enhance chondrogenesis of mesenchymal stem cells through mechanical stimulation and magnetic field effects. The fiber topography of the scaffolds can be tuned with different coatings on magnetic nanoparticles, which selectively up-regulate chondrogenesis or osteogenesis-related genes.

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Magnetic exposure using Samarium Cobalt (SmCO5) increased proliferation and stemness of human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)

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Amniotic membrane mesenchymal stem cells labeled by iron oxide nanoparticles exert cardioprotective effects against isoproterenol (ISO)-induced myocardial damage by targeting inflammatory MAPK/NF-κB pathway

Maryam Naseroleslami et al.

Summary: This study aimed to investigate the protective effects of SPION-labeled MSCs against ISO-induced myocardial injury in the presence of a magnetic field. The results showed that SPION-labeled MSCs significantly improved cardiac function, reduced fibrosis and tissue damage, and suppressed inflammation via a NF-kappa B/MAPK-dependent mechanism. Thus, SPION-labeled MSCs in the presence of a magnetic field could be a beneficial treatment option to reduce inflammation following myocardial injury.

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Magnetization of mesenchymal stem cells using magnetic liposomes enhances their retention and immunomodulatory efficacy in mouse inflamed skeletal muscle

Yusuke Kono et al.

Summary: The study demonstrated that magnetized mesenchymal stem cells (MSCs) have the potential to effectively treat sarcopenia by promoting myogenic cell differentiation and suppressing inflammation. The results showed that magnetized MSCs had a high retention efficiency in inflamed skeletal muscle and could regulate the expression of inflammatory factors through paracrine effects.

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Tian Zhou et al.

Summary: MSC therapy for clinical applications faces challenges due to inconsistent criteria for MSCs identity and their inherited heterogeneity. Strategies have been developed to overcome these challenges with the emergence of advanced biological techniques and substantial improvements in bio-engineered materials.

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Dual anisotropicity comprising 3D printed structures and magnetic nanoparticle assemblies: towards the promotion of mesenchymal stem cell osteogenic differentiation

Ke Hu et al.

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SPION-MSCs enhance therapeutic efficacy in sepsis by regulating MSC-expressed TRAF1-dependent macrophage polarization

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3D magnetic nanocomposite scaffolds enhanced the osteogenic capacities of rat bone mesenchymal stem cells in vitro and in a rat calvarial bone defect model by promoting cell adhesion

Liping Han et al.

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Magnetic Nanoparticles and Magnetic Field Exposure Enhances Chondrogenesis of Human Adipose Derived Mesenchymal Stem Cells But Not of Wharton Jelly Mesenchymal Stem Cells

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Summary: Iron oxide based magnetic nanoparticles (MNP) have versatile applications in biology and medicine. This study compared the chondrogenic conversion of ADSC-MNP and WJMSC under different conditions, finding that ADSC-MNP displayed superior proliferation and chondrogenic potential, with MF exposure further enhancing chondrogenesis in ADSC-MNP. Loading ADSC with MNP may be a promising approach for cartilage engineering in the future.

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Magnetic-driven dynamic culture promotes osteogenesis of mesenchymal stem cell

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Summary: Effective nutrient transport and appropriate mechanical stimulation are crucial for tissue-engineered bone graft production. A magnetic-driven dynamic culture system was designed to mimic the bone tissue microenvironment and facilitate osteogenic differentiation of human umbilical cord mesenchymal stem cells (HUMSCs) on magnetic scaffolds. The study showed that magnetic fields did not affect cell activity but promoted HUMSCs osteogenic differentiation.

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Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model

Ye Ji Ahn et al.

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Improved neural differentiation of stem cells mediated by magnetic nanoparticle-based biophysical stimulation

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Enhanced Homing Technique of Mesenchymal Stem Cells Using Iron Oxide Nanoparticles by Magnetic Attraction in Olfactory-Injured Mouse Models

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