Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11

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Exosomes: the key of sophisticated cell-cell communication and targeted metastasis in pancreatic cancer

Huan Zhang et al.

Summary: Exosomes play a crucial role in pancreatic cancer by facilitating intercellular communication, promoting cancer progression and metastasis, and serving as potential biomarkers for targeted therapy.

CELL COMMUNICATION AND SIGNALING (2022)

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Review Biochemistry & Molecular Biology

A review of the biological role of miRNAs in prostate cancer suppression and progression

Ahmed S. Doghish et al.

Summary: Prostate cancer is a major cause of cancer-related deaths, and miRNA plays a key role in its initiation and progression, serving as potential biomarkers for early diagnosis and personalized treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

The Role of Exosomes in Cancer Progression

Beata Soltesz et al.

Summary: Extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples have been found to play a crucial role in early detection and monitoring of cancer. They contribute to intercellular communication and have implications in tumor formation and metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Exosomal microRNA-23a-3p contributes to the progression of cholangiocarcinoma by interaction with Dynamin3

Qingfeng Ni et al.

Summary: This study revealed the overexpression of miR-23a-3p in cholangiocarcinoma tissues and cell lines, and confirmed its inhibitory effects on cancer cell proliferation and invasion. It further discovered the role of exosomal miR-23a-3p in promoting cancer cell growth and metastasis through interaction with DNM3.

BIOENGINEERED (2022)

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Article Immunology

GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβ R1/SMAD-2 pathway

Feixiang Duan et al.

Summary: This study found that GDF11 can improve SAP, reduce M1 macrophage polarization, and promote M2 macrophage polarization. GDF11 regulates macrophage polarization through the TGF beta R1/smad2 pathway. The findings of this study reveal the mechanism by which GDF11 regulates macrophage polarization in pancreatic tissues and highlights the protective role of GDF11 in SAP.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Gastroenterology & Hepatology

The Tumor Microenvironment in Cholangiocarcinoma Progression

Luca Fabris et al.

HEPATOLOGY (2021)

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Article Cell Biology

MicroRNA-146b-5p suppresses cholangiocarcinoma cells by targeting TRAF6 and modulating p53 translocation

Yiyue Ren et al.

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ACTA HISTOCHEMICA (2021)

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Article Oncology

MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1

Xin Pan et al.

Summary: This study identified a synergistic anti-tumor effect of miR-1182 and let-7a on the development of CCA by down-regulating NUAK1, suggesting novel insights for targeted therapy against CCA.

CANCER CELL INTERNATIONAL (2021)

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Review Oncology

Exosomes and Cell Communication: From Tumour-Derived Exosomes and Their Role in Tumour Progression to the Use of Exosomal Cargo for Cancer Treatment

Andrea Nicolini et al.

Summary: Exosomes, as transporters of bioactive molecules, have gained much interest in the research community for their potential roles in cancer treatment. They can act as biomarkers for diagnosis, immune system modulators, and promoters of cancer metastasis. Further studies are exploring the use of exosomes as carriers of natural substances and drugs for cancer therapy, showing promising potential in cell reprogramming therapy.

CANCERS (2021)

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Article Biotechnology & Applied Microbiology

Integrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans

Bo Chen et al.

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BIOENGINEERED (2021)

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Review Biochemistry & Molecular Biology

The Role of microRNAs in Cholangiocarcinoma

Tingting Shi et al.

Summary: miRNAs play crucial roles in the pathogenesis of cholangiocarcinoma, their potential as biomarkers for diagnosis and prognosis, and their utilization as novel therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Genetics & Heredity

Cancer-associated miRNAs and their therapeutic potential

Jun Inoue et al.

Summary: miRNA plays a role in cancer development and its therapeutics hold promise in inhibiting oncogenic miRNA and replacing tumor suppressive miRNA, potentially improving cancer treatment outcomes.

JOURNAL OF HUMAN GENETICS (2021)

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Article Biotechnology & Applied Microbiology

Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX)

Wulong Wang et al.

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BIOENGINEERED (2021)

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Article Surgery

Meta-analysis and Meta-regression of Survival After Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma

William A. Cambridge et al.

ANNALS OF SURGERY (2020)

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EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

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SCIENCE (2020)

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Gastric Cancer Cell-Derived Exosomal microRNA-23a Promotes Angiogenesis by Targeting PTEN

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FRONTIERS IN ONCOLOGY (2020)

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Article Gastroenterology & Hepatology

Dysregulation of microRNA in cholangiocarcinoma identified through a meta-analysis of microRNA profiling

Somsak Likhitrattanapisal et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Biochemistry & Molecular Biology

GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion

Monserrat Gerardo-Ramirez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11

Federica Ungaro et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Paola Bertuccio et al.

JOURNAL OF HEPATOLOGY (2019)

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Therapeutic Targeting Cancer-Initiating Cell Markers by Exosome miRNA: Efficacy and Functional Consequences Exemplified for claudin7 and EpCAM

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TRANSLATIONAL ONCOLOGY (2019)

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Review Medicine, Research & Experimental

Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer

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Article Biochemistry & Molecular Biology

Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth

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MOLECULAR CANCER (2019)

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Review Cell Biology

Emerging roles of microRNAs in cancer

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CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)

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Review Biochemistry & Molecular Biology

Effect of exosomal miRNA on cancer biology and clinical applications

Zhenqiang Sun et al.

MOLECULAR CANCER (2018)

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Article Biotechnology & Applied Microbiology

GDF 11 restrains tumor growth by promoting apoptosis in pancreatic cancer

Yanzhe Liu et al.

ONCOTARGETS AND THERAPY (2018)

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Article Biotechnology & Applied Microbiology

The role of miR-92b in cholangiocarcinoma patients

Min-hang Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2018)

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Article Gastroenterology & Hepatology

MicroRNA-191 Acts as a Tumor Promoter by Modulating the TET1-p53 Pathway in Intrahepatic Cholangiocarcinoma

Hao Li et al.

HEPATOLOGY (2017)

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Article Cell Biology

Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer

Sameer S. Bajikar et al.

DEVELOPMENTAL CELL (2017)

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Article Oncology

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

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CANCER CELL (2016)

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Article Cell Biology

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Marissa J. Schafer et al.

CELL METABOLISM (2016)

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Article Gastroenterology & Hepatology

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Jesus M. Banales et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

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Gastric cardia adenocarcinoma microRNA profiling in Chinese patients

Shegan Gao et al.

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Review Cell Biology

Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis

Taixue An et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Article Oncology

Chemotherapy for cholangiocarcinoma: An update

Natalia Ramirez-Merino et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2013)

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Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11

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