4.6 Review

Molecular Impact of the Tumor Microenvironment on Multiple Myeloma Dissemination and Extramedullary Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival

Deep Hathi et al.

Summary: This study defines the pathogenic role of VLA4 in multiple myeloma and evaluates an optical tool for measuring its expression.

SCIENTIFIC REPORTS (2022)

Article Oncology

Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages

Julio C. Valencia et al.

Summary: The relationship between cancer and autoimmunity is complex, with MDSCs inducing macrophage reprogramming and affecting tumor progression, immune therapy resistance, and autoimmune disease development.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Macrophage peroxiredoxin 5 deficiency promotes lung cancer progression via ROS-dependent M2-like polarization

Jung Bae Seong et al.

Summary: This study revealed that deficiency of the antioxidant enzyme peroxiredoxin 5 (Prx5) in macrophages induced M2 macrophage polarization, promoting lung cancer progression. However, suppression of ROS generation by N-acetyl cysteine (NAC) inhibited the M2-like polarization of Prx5-deficient macrophages, leading to inhibition of lung cancer cell proliferation and migration, and suppression of tumor growth. These findings suggest that blocking the M2 polarization of macrophages may promote lung cancer regression.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Oncology

Signaling Pathway Mediating Myeloma Cell Growth and Survival

Teru Hideshima et al.

Summary: The bone marrow microenvironment in multiple myeloma is crucial for disease pathogenesis and involves complex interplay between different cells and signaling pathways. Development of combination treatment strategies to target these activated pathways is essential for improving patient outcomes.

CANCERS (2021)

Review Oncology

The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression

Almudena Garcia-Ortiz et al.

Summary: Multiple myeloma is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow, with disease progression influenced by the tumor microenvironment created by various cells and soluble factors. Understanding the elements that control the microenvironment could lead to better-targeted therapies for this incurable disease.

CANCERS (2021)

Article Oncology

Tumor-associated macrophages modulate angiogenesis and tumor growth in a xenograft mouse model of multiple myeloma

Miaomiao Sun et al.

Summary: The study revealed that depleting tumor-associated macrophages can impede the growth of multiple myeloma, and the combination of the drug Clo with VEGFA siRNA can more effectively inhibit tumor growth. Different types of macrophages have varying effects on tumor growth, with M2 promoting growth and M1 inhibiting growth.

LEUKEMIA RESEARCH (2021)

Article Multidisciplinary Sciences

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics

Stephan M. Tirier et al.

Summary: Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

NATURE COMMUNICATIONS (2021)

Article Oncology

The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP, and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib

Pawel Robak et al.

Summary: The study compared the mRNA expression of nine genes that may influence resistance in multiple myeloma patients treated with bortezomib. RPL5 was significantly down-regulated in MM patients, while POMP was significantly up-regulated in bortezomib-refractory patients. High expression of PSMB5 and CXCR, as well as autologous stem cell transplantation, were found to be independent predictors of progression-free survival, while high expression of POMP and RPL5 was associated with shorter overall survival.

CANCERS (2021)

Article Oncology

Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism

Janani Panneerselvam et al.

Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.

CANCERS (2021)

Article Cell Biology

Single-Cell Transcriptomic Analysis Revealed a Critical Role of SPP1/CD44-Mediated Crosstalk Between Macrophages and Cancer Cells in Glioma

Cong He et al.

Summary: High-grade glioma, characterized by extensive tumor heterogeneity, was analyzed through single-cell RNA sequencing to identify cellular and molecular mechanisms driving tumor heterogeneity. The study revealed a dominance of tumor-associated macrophages in the immune microenvironment, along with five distinct subpopulations of tumor cells and highlighted the critical role of the SPP1/CD44 axis in glioma progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Oncology

Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

Shigeki Ito et al.

Summary: The SDF-1 alpha/CXCR4 axis plays crucial roles in multiple myeloma, affecting various physiological processes of tumor cells such as proliferation, survival, invasion, dissemination, and drug resistance. This review highlights the pleiotropic role of this axis and discusses potential targeted therapies in multiple myeloma.

CANCERS (2021)

Article Oncology

Epigenetic Silencing of Immune-Checkpoint Receptors in Bone Marrow- Infiltrating T Cells in Acute Myeloid Leukemia

Ramin Radpour et al.

Summary: In AML, IC ligands and receptors are mainly upregulated in leukemia stem cells, while downregulated in bone marrow-infiltrating CD8(+) T cells due to pathological chromatin remodeling. This suggests that dysfunctional CD8(+) T cells in AML are mainly caused by pathological epigenetic silencing of activating IC receptors, rather than signaling by immune inhibitory IC receptors.

FRONTIERS IN ONCOLOGY (2021)

Article Cell Biology

The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro

Shiqi Zhang et al.

Summary: The OPTN (E50K) mutation disrupts autophagy, leading to TDP-43 aggregation, RGC apoptosis, and retinal thinning. Restoring autophagic flux can reduce TDP-43 aggregation and prevent retinal neurodegeneration.

CELL DEATH DISCOVERY (2021)

Article Pathology

CD56 expression in multiple myeloma: Correlation with poor prognostic markers but no effect on outcome

Epameinondas Koumpis et al.

Summary: The study retrospectively analyzed data from 109 patients with multiple myeloma and found that the expression of CD56 is associated with prognostic parameters, with lack of CD56 expression possibly serving as a marker of poor prognosis in patients. Further prospective studies are needed to evaluate CD56 expression as a predictive biomarker in the era of novel regimens.

PATHOLOGY RESEARCH AND PRACTICE (2021)

Article Hematology

Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα

Ilseyar Akhmetzyanova et al.

Summary: The dissemination and progression of multiple myeloma is associated with an increased inflammatory signature in bone marrow MPs, with CD169(+) MPs playing a critical role in the early spread of myeloma.

BLOOD ADVANCES (2021)

Article Oncology

ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Giada Bianchi et al.

Summary: ROBO1 plays a vital role in promoting the pathogenesis of multiple myeloma, as its knockout affects tumor growth and dissemination in mouse models. The cleaved C-terminus of ROBO1 supports myeloma proliferation.

BLOOD CANCER DISCOVERY (2021)

Article Hematology

Adhesion molecule immunophenotype of bone marrow multiple myeloma plasma cells impacts the presence of malignant circulating plasma cells in peripheral blood

Indre Klimiene et al.

Summary: In patients with relapsed/refractory multiple myeloma (RRMM), a significant loss of adhesion molecules on bone marrow MMPCs in MMCPC+ MM patients was observed, suggesting that these changes may allow cells to leave the bone marrow and enter the peripheral blood.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

Article Oncology

Multiple myeloma current treatment algorithms

S. Vincent Rajkumar et al.

BLOOD CANCER JOURNAL (2020)

Letter Hematology

Phase 1b trial of pembrolizumab monotherapy for relapsed/ refractory multiple myeloma: KEYNOTE-013

Vincent Ribrag et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

Review Oncology

The Tumor Microenvironment Innately Modulates Cancer Progression

Dominique C. Hinshaw et al.

CANCER RESEARCH (2019)

Review Biochemistry & Molecular Biology

Extracellular Vesicles Enhance Multiple Myeloma Metastatic Dissemination

Michela Colombo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

The role of CXCR4 in multiple myeloma: Cells' journey from bone marrow to beyond

Tomalika Rahmat Ullah

JOURNAL OF BONE ONCOLOGY (2019)

Article Oncology

Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Satoshi Takagi et al.

CLINICAL CANCER RESEARCH (2018)

Article Hematology

Mechanisms coupling thrombin to metastasis and tumorigenesis

Allison S. Remiker et al.

THROMBOSIS RESEARCH (2018)

Article Immunology

An early history of T cell-mediated cytotoxicity

Pierre Golstein et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Endocrinology & Metabolism

Adipose, Bone, and Myeloma: Contributions from the Microenvironment

Michelle M. McDonald et al.

CALCIFIED TISSUE INTERNATIONAL (2017)

Article Medicine, General & Internal

Multiple myeloma

Shaji K. Kumar et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Cell & Tissue Engineering

Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy

Ramin Radpour

WORLD JOURNAL OF STEM CELLS (2017)

Review Hematology

Prevalence of symptoms in patients with multiple myeloma: a systematic review and meta-analysis

Christina Ramsenthaler et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2016)

Review Immunology

The PD1:PD-L1/2 Pathway from Discovery to Clinical implementation

Kankana Bardhan et al.

FRONTIERS IN IMMUNOLOGY (2016)

Review Oncology

Bone metastasis: the importance of the neighbourhood

Peter I. Croucher et al.

NATURE REVIEWS CANCER (2016)

Article Medicine, General & Internal

Multiple myeloma

Christoph Roellig et al.

LANCET (2015)

Article Multidisciplinary Sciences

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Michelle A. Lawson et al.

NATURE COMMUNICATIONS (2015)

Article Peripheral Vascular Disease

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

Nadine Jetten et al.

ANGIOGENESIS (2014)

Article Multidisciplinary Sciences

Platelets guide the formation of early metastatic niches

Myriam Labelle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, Research & Experimental

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression

Aldo M. Roccaro et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

The impact of Aggrus/podoplanin on platelet aggregation and tumour metastasis

Naoya Fujita et al.

JOURNAL OF BIOCHEMISTRY (2012)

Review Endocrinology & Metabolism

Osteoblast function in myeloma

G. David Roodman

Editorial Material Oncology

Unusual myeloma relapse after thalidomide therapy: The dark side of the moon?

Enrico Balleari et al.

LEUKEMIA RESEARCH (2009)

Review Oncology

Extravasation and homing mechanisms in multiple myeloma

Isabelle Vande Broek et al.

CLINICAL & EXPERIMENTAL METASTASIS (2008)

Review Biochemistry & Molecular Biology

Recent advances in the treatment of multiple myeloma

Hiroshi Yasui et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2006)

Article Medicine, General & Internal

Clinical course of patients with relapsed multiple myeloma

SK Kumar et al.

MAYO CLINIC PROCEEDINGS (2004)

Article Hematology

Clinicopathological and prognostic characteristics of CD56-negative multiple myeloma

N Sahara et al.

BRITISH JOURNAL OF HAEMATOLOGY (2002)