4.6 Article

Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Integrative analysis of CRISPR screening data uncovers new opportunities for optimizing cancer immunotherapy

Yan Li et al.

Summary: Functional genetic immuno-oncology screens have been used to identify potential regulators in tumor-immune interactions. This study collected and analyzed the data from these screens and identified 105 regulator genes. A novel immune-oncology target called MON2 was also discovered. Furthermore, a signature named CTIS was developed to predict response to immune checkpoint blockade and improve the efficacy of immunotherapy agents.

MOLECULAR CANCER (2022)

Review Biotechnology & Applied Microbiology

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Yicheng Jiang et al.

Summary: Recent studies have shown that imbalanced copper homeostasis can affect tumor growth, causing irreversible damage. Copper can induce various forms of cell death, such as apoptosis and autophagy, through mechanisms involving reactive oxygen species accumulation, proteasome inhibition, and antiangiogenesis. This review highlights the antitumor mechanisms of copper, the development of biomaterials and nanotechnology incorporating copper, and the clinical applications of novel copper complexes.

NANOMEDICINE (2022)

Article Multidisciplinary Sciences

Compartmentalized metabolism supports midgestation mammalian development

Ashley Solmonson et al.

Summary: This study investigated the metabolic changes in the placenta and embryo during midgestation in mice, identifying differences between the tissues and the contribution of glucose to the tricarboxylic acid (TCA) cycle. The deficiency of LIPT1, an enzyme related to the TCA cycle, disrupted metabolism and led to developmental anomalies and embryonic demise.

NATURE (2022)

Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

Article Biochemistry & Molecular Biology

Downregulation of dihydrolipoyl dehydrogenase by UVA suppresses melanoma progression via triggering oxidative stress and altering energy metabolism

Silvia Yumnam et al.

Summary: Suppressing dihydrolipoyl dehydrogenase (DLD) increases intracellular ROS production, decreases mitochondrial membrane potential, induces autophagic cell death, and significantly inhibits melanoma growth and proliferation. Furthermore, DLD suppression alters energy metabolism in melanoma cells.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson's disease

Jianjian Dong et al.

Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.

CELL DEATH & DISEASE (2021)

Article Oncology

High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types

D. J. McGrail et al.

Summary: Analysis of over 10,000 patient tumors from The Cancer Genome Atlas showed that TMB-H tumors had significantly higher response rates to immune checkpoint blockade in certain cancer types, while showing no significant benefit in others. These results do not support the use of TMB-H as a biomarker for ICB treatment across all solid cancer types, indicating the need for further tumor type-specific studies.

ANNALS OF ONCOLOGY (2021)

Article Pharmacology & Pharmacy

FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma

Zeyu Zhang et al.

Summary: This study constructed a risk signature related to LUAD using RNA-sequencing data and the LASSO algorithm, demonstrating that the risk signature is an independent risk factor for LUAD patients. Specifically focusing on the FDX1 gene, it was found that FDX1 promotes ATP production and is closely related to glucose metabolism, fatty acid oxidation, and amino acid metabolism.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

Xueying Ren et al.

Summary: DSF/Cu selectively exerts efficient cytotoxic effect on HCC cells, inhibits migration, invasion, and angiogenesis of HCC cells, impairs mitochondrial homeostasis, increases free iron pool, enhances lipid peroxidation, and eventually results in ferroptotic cell death. Inhibition of NRF2 elevation strengthens HCC cells more vulnerable to DSF/Cu induced ferroptosis.

REDOX BIOLOGY (2021)

Article Oncology

Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Wei Gao et al.

Summary: Elesclomol inhibits colorectal cancer by inducing copper overload, promoting oxidative stress, and regulating ferroptosis through targeting ATP7A.

MOLECULAR ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

Zhen Cai et al.

MOLECULAR CELL (2020)

Review Cell Biology

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

Vinit Shanbhag et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe

Troy F. Langford et al.

NATURE COMMUNICATIONS (2018)

Review Chemistry, Multidisciplinary

Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function

Suzanne M. Adam et al.

CHEMICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Article Multidisciplinary Sciences

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

Perrine Goguet-Rubio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemical Research Methods

Orchestrating high-throughput genomic analysis with Bioconductor

Wolfgang Huber et al.

NATURE METHODS (2015)

Article Multidisciplinary Sciences

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Eliezer M. Van Allen et al.

SCIENCE (2015)

Review Biochemistry & Molecular Biology

Gene Copy-Number Alterations: A Cost-Benefit Analysis

Yun-Chi Tang et al.

Article Engineering, Environmental

Copper-Induced Deregulation of microRNA Expression in the Zebrafish Olfactory System

Lu Wang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

Masazumi Nagai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Multidisciplinary Sciences

Affinity gradients drive copper to cellular destinations

Lucia Banci et al.

NATURE (2010)

Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Bioconductor: open software development for computational biology and bioinformatics

RC Gentleman et al.

GENOME BIOLOGY (2004)