期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.896426
关键词
acute myeloid leukemia; leukemia stem cells; drug resistance; resistant mechanisms; LSCs remolding; clonal heterogeneity
类别
This review summarizes the resistance mechanisms of leukemia stem cells (LSCs) and the crucial role of the bone marrow microenvironment in LSCs resistance in acute myeloid leukemia (AML), providing better strategies for future research on eradicating LSCs and clinical treatment of AML.
Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological malignancy. Relapse and refractory after induction chemotherapy are still challenges for curing AML. Leukemia stem cells (LSCs), accepted to originate from hematopoietic stem/precursor cells, are the main root of leukemogenesis and drug resistance. LSCs are dynamic derivations and possess various elusive resistance mechanisms. In this review, we summarized different primary resistance and remolding mechanisms of LSCs after chemotherapy, as well as the indispensable role of the bone marrow microenvironment on LSCs resistance. Through a detailed and comprehensive review of the spectacle of LSCs resistance, it can provide better strategies for future researches on eradicating LSCs and clinical treatment of AML.
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