期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.914060
关键词
TRPM8; pan-cancer; immune cell infiltration; tumor microenvironment; DNA repair
类别
资金
- Guizhou Nursing Vocational College Foundation [gzhlyj2021-02]
- Science and Technology Foundation of Guizhou Provincial Health Committee [gzwkj2022-518]
- Jiangsu Province Shuangchuang Talent Plan [JSSCRC 2021533]
TRPM8 is strongly associated with tumor physiology and immunity and has the potential to be a treatment target or biomarker for determining the prognosis of a specific type of cancer.
BackgroundTransient receptor potential melastatin 8 (TRPM8) modulates tumor biology and sensitivity to treatment. The present study aimed to determine the part it plays in tumor immunity and physiology using pan-cancer analysis. MethodData from the GTEx, CCLE, TISIDB, GSCA, cBioportal, and TCGA databases were collected using Estimate, Scanneo, and GSEA, and the associations between TRPM8 and prognosis, molecular subtypes, mutational burden, microsatellite instability, immune gene functions, and drug sensitivity were analyzed in 33 tumor types. ResultTRPM8 levels were found to be elevated in most tumors, particularly in solid tumors, with variations according to clinical stage. Mutation frequency was greatest in endometrial carcinoma. High levels of TRPM8 were linked to unfavorable prognosis, immune cell infiltration, and the tumor microenvironment, as well as correlating with abnormalities in the transcription levels of genes associated with immunity and DNA repair. TRPM8 was also linked to unfavorable patient outcomes and cancer-associated signaling. ConclusionsTRPM8 is strongly associated with tumor physiology and immunity. The Pan-Cancer analysis suggests the potential of TRPM8 as a treatment target or biomarker for determining the prognosis of a specific type of cancer.
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