期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.981036
关键词
gene deletion; copy number variation; acute lymphoblastic leukemia; CDKN2A; 2B deletion; IKZF1 deletion; PAX5 deletion; prognosis
类别
资金
- Basic Scientific Research Project of National Universities
- [332021059]
This review primarily discusses the most prevalent CNVs in B-ALL, aiming to elucidate their clinical value and the importance of personalized management.
Copy number variations (CNVs) are widespread in both pediatric and adult cases of B-cell acute lymphoblastic leukemia (B-ALL); however, their clinical significance remains unclear. This review primarily discusses the most prevalent CNVs in B-ALL to elucidate their clinical value and further personalized management of this population. The discovery of the molecular mechanism of gene deletion and the development of targeted drugs will further enhance the clinical prognosis of B-ALL.
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