Identification of molecular subtypes, risk signature, and immune landscape mediated by necroptosis-related genes in non-small cell lung cancer

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CCNE1 Promotes Progression and is Associated with Poor Prognosis in Lung Adenocarcinoma

Guoliang Ma et al.

Summary: High expression of CCNE1 is associated with malignant behavior, metastasis, and poor prognosis in lung adenocarcinoma.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Integrative Analysis of m6A RNA Methylation Regulators and the Tumor Immune Microenvironment in Non-Small-Cell Lung Cancer

Jiaqi Zhu et al.

Summary: This study investigates the role of m6A RNA methylation regulators in the tumor immune microenvironment of NSCLC patients. The m6Ascore, which quantifies the m6A modification patterns of individual tumors, was constructed and found to be associated with clinical prognosis and immunotherapeutic response. Lower m6Ascore was associated with better prognosis and higher efficacy of immunotherapy.

DISEASE MARKERS (2022)

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Article Medicine, General & Internal

A Novel Prognostic Predictor of Immune Micro-environment and Therapeutic Response in Kidney Renal Clear Cell Carcinoma based on Necroptosis-related Gene Signature

Wenwei Chen et al.

Summary: This study found that necroptosis-related genes can be used to predict the survival outcomes and therapeutic response of kidney renal clear cell carcinoma patients, and also have an impact on the immune microenvironment. These findings are of great significance for the treatment and prognosis of kidney renal clear cell carcinoma.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

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Article Oncology

Identification of SRXN1 and KRT6A as Key Genes in Smoking-Related Non-Small-Cell Lung Cancer Through Bioinformatics and Functional Analyses

Jiazhen Zhou et al.

Summary: SRXN1 and KRT6A have been identified as oncogenes in non-small-cell lung cancer (NSCLC), and they may serve as biomarkers for smoking exposure, early diagnosis, and prognosis.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

REC8 inhibits proliferation, migration and invasion of breast cancer cells by targeting CDC20

Shaodan He et al.

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MOLECULAR MEDICINE REPORTS (2022)

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Article Biotechnology & Applied Microbiology

TRIP13 Induces Nedaplatin Resistance in Esophageal Squamous Cell Carcinoma by Enhancing Repair of DNA Damage and Inhibiting Apoptosis

Lin-Ting Zhang et al.

Summary: This study found that high expression of TRIP13 can promote proliferation and migration of esophageal squamous cell carcinoma (ESCC) cells, and induce resistance to nedaplatin (NDP) by enhancing DNA damage repair and inhibiting apoptosis.

BIOMED RESEARCH INTERNATIONAL (2022)

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FGA Controls VEGFA Secretion to Promote Angiogenesis by Activating the VEGFR2-FAK Signalling Pathway

Hui Li et al.

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FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Oncology

Aberrant Expression of BUB1B Contributes to the Progression of Thyroid Carcinoma and Predicts Poor Outcomes for Patients

Hai-Chao Yan et al.

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JOURNAL OF CANCER (2022)

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Article Oncology

Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

Yinfei Tan et al.

Summary: The study revealed that RIPK3 loss in malignant mesothelioma is associated with epigenetic silencing through DNA methylation, impairing necroptosis and contributing to chemoresistance and poor survival outcomes.

CLINICAL CANCER RESEARCH (2021)

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Review Oncology

Targeting mutant p53 for cancer therapy: direct and indirect strategies

Jiahao Hu et al.

Summary: TP53 is a critical tumor-suppressor gene commonly mutated in human cancers, with potential oncogenic properties when mutated. Treatments for cancers with mutant p53 involve targeting mutant p53 directly, restoring wild-type functions, and exploring synthetic lethal interactions with mutant p53 for therapeutic benefits. Additionally, disrupting noncoding RNA networks may have potential synthetic lethal effects in cancers with p53 mutations.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Immunology

Genomic, Immunological, and Clinical Characterization of Pyroptosis in Ovarian Cancer

Min Zhou et al.

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JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Oncology

Increased tensin 4 expression is related to the histological type of gastric cancer

Marcin Niziol et al.

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WORLD JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Cell Biology

MiR-532-3p suppresses cell viability, migration and invasion of clear cell renal cell carcinoma through targeting TROAP

Bin Gao et al.

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CELL CYCLE (2021)

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Review Biochemistry & Molecular Biology

Current and Future Development in Lung Cancer Diagnosis

Reem Nooreldeen et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

IL-6/STAT3 signaling pathway regulates the proliferation and damage of intestinal epithelial cells in patients with ulcerative colitis via H3K27ac

Yanrong Li et al.

Summary: The IL-6/STAT3 signaling pathway plays a crucial role in intestinal epithelial barrier injury in patients with ulcerative colitis (UC) by influencing the expression of tight junction-related proteins and the H3K27ac level. The significantly increased expression level of IL-6 in the peripheral blood of UC patients is positively associated with the development of UC.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Oncology

Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes

Takuro Yamauchi et al.

Summary: This study investigated the diagnostic and prognostic significance of mixed lineage kinase domain-like protein (MLKL) and phosphorylated MLKL (pMLKL) in esophageal squamous cell carcinoma (ESCC) patients, as well as their correlations with the tissue microenvironment. High pMLKL status was found to be significantly correlated with worse prognosis in ESCC patients, indicating its potential involvement in the tumor microenvironment and therapeutic efficacy.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Genetic Markers in Lung Cancer Diagnosis: A Review

Katarzyna Wadowska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Risk-Based lung cancer screening: A systematic review

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LUNG CANCER (2020)

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Review Biochemistry & Molecular Biology

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MOLECULAR CANCER (2020)

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Expression of key regulatory genes in necroptosis and its effect on the prognosis in non-small cell lung cancer

Ji Eun Park et al.

JOURNAL OF CANCER (2020)

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The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

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Review Medicine, Research & Experimental

RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

Yuping Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

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Article Immunology

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

Annelise G. Snyder et al.

SCIENCE IMMUNOLOGY (2019)

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A Phase II Trial of Osimertinib in the Second-Line Treatment of Non-small Cell Lung Cancer with the EGFR T790M Mutation, Detected from Circulating Tumor DNA: LiquidLung-O-Cohort 2

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CANCER RESEARCH AND TREATMENT (2019)

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Patient and carer perceived barriers to early presentation and diagnosis of lung cancer: a systematic review

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BMC CANCER (2019)

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Pyroptosis versus necroptosis: similarities, differences, and crosstalk

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Update on Immunohistochemistry for the Diagnosis of Lung Cancer

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Necroptosis microenvironment directs lineage commitment in liver cancer

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Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

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The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

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CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis

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Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

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Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

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Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

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Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer

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Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

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Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients

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Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

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Genetic Predisposition in Degenerative Lumbar Scoliosis due to the Copy Number Variation

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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Identification of molecular subtypes, risk signature, and immune landscape mediated by necroptosis-related genes in non-small cell lung cancer

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