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MicroRNAs as Potential Tools for Predicting Cancer Patients' Susceptibility to SARS-CoV-2 Infection and Vaccination Response

CELLS (2022)

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Article Biochemistry & Molecular Biology

Computational Design of Miniproteins as SARS-CoV-2 Therapeutic Inhibitors

Bahaa Jawad et al.

Summary: In this study, miniprotein RBD inhibitors were designed and simulated using molecular dynamics (MD) simulations and ab initio density functional theory (DFT) calculations. Through truncation and amino acid substitutions, the binding affinity with RBD was enhanced, providing insights into general principles for designing potential therapeutics for SARS-CoV-2.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Endocrinology & Metabolism

Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with obesity

Jayanthi Bellae Papannarao et al.

Summary: The upregulation of miR-200c and miR-let-7b in individuals with obesity is associated with the downregulation of ACE2, potentially increasing susceptibility to COVID-19. Therefore, the level of miR-200c may serve as a potential early biomarker for identifying individuals at risk of severe COVID-19.

INTERNATIONAL JOURNAL OF OBESITY (2022)

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Article Biochemistry & Molecular Biology

Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p

Joshua A. Imperatore et al.

Summary: The study reveals the conservation and functional importance of the s2m element in the genome of SARS-CoV-2 and other coronaviruses. The s2m element is involved in the dimerization of the viral genome and interacts with host cellular microRNA. These findings suggest that the s2m element could be a potential therapeutic target for COVID-19 and other coronavirus-related diseases.

NUCLEIC ACIDS RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene

S. M. Akula et al.

Summary: The role of circulating miRNAs as biomarkers for COVID-19 remains uncertain. However, analysis of circulating miRNA profiles in COVID-19 patients revealed significant changes, with miR-150-5p potentially playing a crucial role in SARS-CoV-2 infection. Further investigation into the mechanism by which COVID-19-induced changes in miR-150-5p levels may promote SARS-CoV-2 infection is warranted.

RNA BIOLOGY (2022)

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Review Virology

The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-review

Sujay Paul et al.

Summary: This article explores the clinical relevance and biological roles of miRNAs in COVID-19. It suggests that miRNAs could serve as potential biomarkers and therapeutic targets for this disease, aiding in diagnosis and treatment.

VIRUS RESEARCH (2022)

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Review Virology

miRNAs, from Evolutionary Junk to Possible Prognostic Markers and Therapeutic Targets in COVID-19

Brandon Bautista-Becerril et al.

Summary: The COVID-19 pandemic has highlighted the importance of prognostic predictors and therapeutic targets in the disease. miRNA biomolecules have been shown to play a vital role in regulating genes associated with the pathophysiology of COVID-19 and can be used as predictors of complications and potential targets for treatment. However, further studies are needed to confirm these findings.

VIRUSES-BASEL (2022)

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Article Biochemistry & Molecular Biology

Penetration of the SARS-CoV-2 Spike Protein across the Blood-Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical Biosensing

Daniel Petrovszki et al.

Summary: This study evaluated the barrier penetration of the SARS-CoV-2 spike protein in model systems of human organs highly exposed to the infection. The findings showed that the spike protein effectively crossed the human brain endothelial cell barrier and had a lower passage through the intestinal barrier cell layer. These results provide a basis for further research on the mechanism and consequences of spike protein penetration across the blood-brain barrier to the brain.

BIOMEDICINES (2022)

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Article Infectious Diseases

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Shahrokh Abdolahi et al.

Summary: This study investigated the miRNA and inflammatory cytokine levels related to ACE2 gene expression in SARS-CoV-2 infection. The results showed that the expression levels of miR-200c-3p and miR-421-5p, as well as CD4, CD25, and Foxp3, significantly decreased, while IL-6 expression notably increased at the time of admission for COVID-19 patients. However, by the time of discharge, the expression levels of these genes were opposite to the time of admission.

INFECTION GENETICS AND EVOLUTION (2022)

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Article Biochemistry & Molecular Biology

Mutations of Omicron Variant at the Interface of the Receptor Domain Motif and Human Angiotensin-Converting Enzyme-2

Puja Adhikari et al.

Summary: The Omicron variant of SARS-CoV-2, with numerous mutations in the spike protein, spreads quickly, evades immune defense, and reduces the effectiveness of existing vaccines. Computational modeling and analysis reveal that the mutations in Omicron alter the shape, structure, and positive charge of amino acid-amino acid bond pair units (AABPU), leading to increased binding strength with ACE2.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

Annika Fendler et al.

Summary: The efficacy and immunogenicity of COVID-19 vaccines in cancer patients are uncertain due to their exclusion from pivotal clinical trials. In this Review, the current knowledge on vaccine efficacy and immune responses in cancer patients is summarized, highlighting key factors that may affect vaccine efficacy in this population.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Primary Health Care

Early Response of Primary Care Practices to COVID-19 Pandemic

Gina Keppel et al.

Summary: This study describes how a diverse group of primary care practices rapidly implemented a variety of operational adaptations at the onset of the COVID-19 pandemic to address patient needs and maintain patient and staff safety. Telemedicine played a critical role in maintaining delivery of care.

JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH (2022)

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Article Multidisciplinary Sciences

Intelligent system based comparative analysis study of SARS-CoV-2 spike protein and antigenic proteins in different types of vaccines

Rabeb Touati et al.

Summary: This study compares the main antigenic protein sequences of existing vaccines with the S protein of the SARS-CoV-2 genome. The results suggest a possible protective effect of Poliovirus, HIB, Hepatitis B, PCV10, Measles, Mumps, and Rubella (MMR) vaccines against COVID-19.

BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES (2022)

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Article Oncology

Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p

Yue Zhao et al.

Summary: The study demonstrates that circABCB10 can enhance irradiation sensitivity in breast cancer by negatively regulating glycolysis through the miR-223-3p/PFN axis.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2021)

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Review Oncology

Mortality in hospitalized patients with cancer and coronavirus disease 2019: A systematic review and meta-analysis of cohort studies

Aakash Desai et al.

Summary: The analysis of 2922 cancer patients with COVID-19 from primarily inpatient studies showed a 30-day mortality rate of 30%, while the overall rate was 15% among 624 patients from studies including both inpatient and outpatient populations. Factors such as male sex, older age, cancer subtype, and recent active cancer therapy partially explained the heterogeneity in mortality reporting, with male sex and an interaction between patient age and recent therapy accounting for most of the variance in mortality rates between studies.

CANCER (2021)

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Review Cell Biology

MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents?

Farshad Abedi et al.

Summary: Proposed therapies and antiviral drugs have so far been ineffective in curing COVID-19 patients, but there are vaccine candidates seeking emergency use authorization. Recent studies have highlighted the role of miRNAs in the pathophysiology of COVID-19, suggesting their potential as biomarkers or antiviral agents in therapy.

CELL CYCLE (2021)

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Review Medicine, Research & Experimental

Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field

Marilia B. Visacri et al.

Summary: This review included 20 studies, which suggested that miR-21-5p, miR-146a, miR-126-3p, miR-144 and miR-155 are important dysregulated miRNAs in COVID-19 that could be used as biomarkers for diagnosis and severity indication. MiRNAs play key roles in viral replication, proliferation of infected cells, immune response, inflammation, and cardiovascular dysfunction.

BIOMARKERS IN MEDICINE (2021)

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Article Cell Biology

Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR-98-5p-Sponged IL-10

Yan Wang et al.

Summary: This study reveals the protective role of lncRNA MEG3 in the development of UC and may provide potential therapeutic targets for UC.

INFLAMMATION (2021)

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Article Infectious Diseases

Circulating miRNAs: Potential diagnostic role for coronavirus disease 2019 (COVID-19)

Mohammad Fayyad-Kazan et al.

Summary: The study compared the expression of circulating miRNAs in COVID-19 patients and healthy donors, revealing miR-19a-3p, miR-19b-3p, and miR-92a-3p as potential diagnostic biomarkers and therapeutic targets. ROC curve analyses showed high AUC values for these miRNAs, indicating their robust diagnostic value.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Virology

Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint

Taruneet Kaur et al.

Summary: The study aims to computationally screen and identify potential miRNAs for early prevention of COVID-19 by suppressing Tmprss2, with in vitro experimental validation confirming silencing of Tmprss2 with certain miRNAs.

VIRUS RESEARCH (2021)

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Review Engineering, Biomedical

miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools

Leonardo J. Galvao-Lima et al.

Summary: This paper systematically reviews the miRNAs related to cancer development and identifies potential miRNAs for early cancer diagnosis. Through the selection of papers, new methods for disease screening and diagnosis are revealed through this research.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Article Medicine, Research & Experimental

MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis

Keqin Zhou et al.

Summary: The study found that miR-223-3p is significantly upregulated in clinically collected urine samples and PCa cells with low radiosensitivity. Enhancing miR-223-3p further reduces radiosensitivity, while inhibiting miR-223-3p improves radiosensitivity of PC3 and LNCaP cells. miR-223-3p regulates radiosensitivity by enhancing cell glycolysis.

LIFE SCIENCES (2021)

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Article Medical Laboratory Technology

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

David De Gonzalo-Calvo et al.

Summary: This study demonstrated a close association between the circulating miRNA profile of COVID-19 patients and disease severity. Analysis of miRNA levels proved useful in distinguishing between ICU patients and ward patients, as well as between ICU nonsurvivors and survivors. The potential of miRNA signatures in predicting disease progression in critical COVID-19 patients was found to be superior to traditional laboratory parameters such as leukocyte counts, CRP, and D-dimer levels.

TRANSLATIONAL RESEARCH (2021)

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Article Medicine, General & Internal

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Robert Challen et al.

Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Biotechnology & Applied Microbiology

MicroRNA miR-145-5p regulates cell proliferation and cell migration in colon cancer by inhibiting chemokine (C-X-C motif) ligand 1 and integrin α2

Wei Zhuang et al.

Summary: This study aimed to investigate the regulatory function of microRNA miR-145-5p in colon cancer (CC) cells, confirming that miR-145-5p is a tumor suppressor and can inhibit the expression of CXCL1 and ITGA2, key genes in CC. Upregulation of miR-145-5p attenuated proliferation and migration of CC cells, with luciferase assay and western blotting confirming CXCL1 and ITGA2 as targets of miR-145-5p.

BIOENGINEERED (2021)

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Article

LINC00665 Targets miR-214-3p/MAPK1 Axis to Accelerate Hepatocellular Carcinoma Growth and Warburg Effect

Hongyu Wan et al.

Journal of Oncology (2021)

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Review Medicine, General & Internal

Clinical considerations for critically ill COVID-19 cancer patients: A systematic review

Chidambaram Ramasamy et al.

Summary: Patients with cancer are more vulnerable to COVID-19 infection due to advanced age, frailty, medical comorbidities, immunosuppression, and frequent health care visits. Factors associated with worse outcomes from COVID-19 infections among cancer patients include male gender, age >= 65 years, higher comorbidity burden, and smoking history.

WORLD JOURNAL OF CLINICAL CASES (2021)

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Review Virology

The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection

Jiulue Hu et al.

Summary: miRNAs play a significant role in inhibiting the replication of SARS-CoV-2 and have the potential to be used as therapeutic agents against COVID-19. Novel miRNA delivery strategies, such as EDV (TM) nanocells, show promise for targeting lung tissue for SARS-CoV-2 treatment.

ARCHIVES OF VIROLOGY (2021)

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Article Biology

miR-145-5p as a predictive biomarker for breast cancer stemness by computational clinical investigation

Dheeran Rajarajan et al.

Summary: In this study, miR-145-5p was identified as a common miRNA targeting stemness markers in breast cancer, with lower expression in patients compared to healthy individuals. The combination of low miR-145-5p and high SOX2 expression was associated with a poor overall survival rate. Pathway enrichment analysis revealed that SOX2 is highly enriched with transcription factors and upregulated in axillary metastatic lymph nodules.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Review Infectious Diseases

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

Rafael Marchi et al.

Summary: MicroRNAs play crucial roles in SARS-CoV-2 infection and COVID-19 by regulating the immune response through interfering with viral gene cleavage and translation. The potential therapeutic use of miRNAs against COVID-19 and other viral infections has been highlighted in the identified studies.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Medicine, Research & Experimental

MicroRNA-28-3p inhibits angiotensin-converting enzyme 2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus 2 by targeting A disintegrin and metalloproteinase 17

Yun Xu et al.

Summary: The study revealed that miR-28-3p plays a crucial role in regulating ACE2 ectodomain shedding through ADAM17 in 293T cells treated with SARS-CoV-2 S-protein, suggesting a potential therapeutic role of miR-28-3p mimic in the prevention and treatment of SARS-CoV-2 patients.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

In Silico and In Vitro Analyses Validate Human MicroRNAs Targeting the SARS-CoV-2 3′-UTR

Maria Asuncion Barreda-Manso et al.

Summary: The study identified 10 potential candidates of human microRNAs targeting the SARS-CoV-2 genome through bioinformatics screening. Among them, hsa-miR-3941 and hsa-miR-138-5p showed effective targeting of the virus genome and complementary antiviral or protective effects in host cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Rheumatology

Downregulation of miR-98-5p expression induces interleukin-6 expression in rheumatoid fibroblast-like synoviocytes

Shujun Wang et al.

Summary: The study investigated the regulation of IL-6 expression by miR-98-5p in rheumatoid fibroblast-like synoviocytes. Results showed that miR-98-5p negatively regulated IL-6 expression and could be a potential clinical approach in treating rheumatoid arthritis.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2021)

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Article Biochemistry & Molecular Biology

Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2

Akira Sato et al.

Summary: This study found that a specific human microRNA may suppress viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2021)

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Editorial Material Immunology

COVID-19 vaccination for cancer patients: Evidence, priority, and practice

Shiv Rajan et al.

VACCINE (2021)

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Article Cell Biology

LncRNA RCAT1 promotes tumor progression and metastasis via miR-214-5p/E2F2 axis in renal cell carcinoma

Renbo Guo et al.

Summary: This study identified an uncharacterized and upregulated lncRNA RCAT1 in renal cell carcinoma, which played a key role in cell proliferation and metastasis by modulating the miR-214-5p/E2F2 axis, suggesting that lncRNA RCAT1 might be a new prognostic biomarker and potential therapeutic target for renal cell carcinoma.

CELL DEATH & DISEASE (2021)

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Review Immunology

Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After Vaccination

Hiroyuki Oshiumi

Summary: Vaccination is the best way to prevent infectious diseases, but vaccine efficacy and adverse reactions vary among individuals. miRNAs in serum EVs can regulate immune responses and vaccine efficacy, such as miR-192 and miR-21. EV miRNAs can be used as tools to improve vaccine efficacy and predict immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Genetics & Heredity

Human MicroRNAs Interacting With SARS-CoV-2 RNA Sequences: Computational Analysis and Experimental Target Validation

Chiara Siniscalchi et al.

Summary: This study identified specific cellular miRNAs that interact with SARS-CoV-2 sequences, demonstrating experimental evidence of their binding and potential therapeutic implications. The interaction between miRNAs and viral sequences was validated through luciferase reporter assays, offering insights into the molecular mechanisms underlying virus infection and potential therapeutic interventions. The study also highlighted the conservation of viral target sequences in recent variants, suggesting the importance of targeting these miRNAs for developing innovative diagnostic tools and interventions.

FRONTIERS IN GENETICS (2021)

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Article Cell Biology

Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2

Jae Hyun Park et al.

Summary: Extracellular vesicles are nanometer-scaled, membrane-bound materials released by cells, containing diverse contents such as proteins and nucleic acids. These vesicles have shown potential as therapeutic agents for SARS-CoV-2 infection by inhibiting viral replication and mediating anti-viral responses through miRNAs.

CELLS (2021)

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Article Cell Biology

SPINT1-AS1 Drives Cervical Cancer Progression via Repressing miR-214 Biogenesis

Hongjuan Song et al.

Summary: Accumulating evidence has shown dysregulated expression and critical roles of non-coding RNAs in various malignancies, including cervical cancer. In this study, a novel cervical cancer-associated lncRNA called SPINT1-AS1 was identified, which represses miR-214 biogenesis and activates Wnt/β-catenin signaling to promote cervical cancer progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

LncRNA FTX promotes the malignant progression of colorectal cancer by regulating the miR-214-5p-JAG1 axis

Luxiang Pan et al.

Summary: The study revealed that lncRNA FTX is upregulated in CRC tissues and sequesters miR-214-5p to release its repression on JAG1, driving the malignant progression of CRC.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Risk Factors for SARS-CoV-2 Infection, Pneumonia, Intubation, and Death in Northeast Mexico

Hid Felizardo Cordero-Franco et al.

Summary: Despite social distancing measures, COVID-19 infections and deaths continued to rise, especially in Mexico in early 2021. This case-control study in Nuevo Leon highlighted older age, male gender, diabetes, hypertension, and obesity as risk factors for infection, complications, and death. Timely identification of high-risk groups exposed to pre-existing conditions is crucial in prioritizing preventive measures against the virus.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Biochemistry & Molecular Biology

Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Yanbo Wang et al.

Summary: The study found that miRNA in serum can directly inhibit SARS-CoV-2 replication, and there are differences in the response to COVID-19 between young people and the elderly or people with comorbidities.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Oncology

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CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Oncology

MiR-214 Mediates Cell Proliferation and Apoptosis of Nasopharyngeal Carcinoma Through Targeting Both WWOX and PTEN

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CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2020)

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Letter Medicine, General & Internal

Presumed Asymptomatic Carrier Transmission of COVID-19

Yan Bai et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Editorial Material Oncology

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

Wenhua Liang et al.

LANCET ONCOLOGY (2020)

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Review Oncology

Angiotensin-converting enzyme 2 (ACE2),SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19)

Arno R. Bourgonje et al.

JOURNAL OF PATHOLOGY (2020)

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Review Oncology

Cancer and COVID-19: Unmasking their ties

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CANCER TREATMENT REVIEWS (2020)

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Review Oncology

Cancer, immune suppression and Coronavirus Disease-19 (COVID-19): Need to manage drug safety (French Society for Oncology Pharmacy [SFPO] guidelines)

Florian Slimano et al.

CANCER TREATMENT REVIEWS (2020)

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Review Microbiology

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

Leon Tribolet et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Infectious Diseases

The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19

Qing Ye et al.

JOURNAL OF INFECTION (2020)

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Article Multidisciplinary Sciences

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Potently neutralizing and protective human antibodies against SARS-CoV-2

Seth J. Zost et al.

NATURE (2020)

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Article Virology

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

Elif Damla Arisan et al.

VIRUSES-BASEL (2020)

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Article Medicine, Research & Experimental

A new approach for COVID-19 treatment by micro-RNA

Sobhy Hassab El-Nabi et al.

MEDICAL HYPOTHESES (2020)

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Article Oncology

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID-19

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CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy

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NON-CODING RNA RESEARCH (2020)

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Article Infectious Diseases

Socio-economic inequality in global incidence and mortality rates from coronavirus disease 2019: an ecological study

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NEW MICROBES AND NEW INFECTIONS (2020)

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Article Biochemistry & Molecular Biology

miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19

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BIOMEDICINES (2020)

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Article Cardiac & Cardiovascular Systems

MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Impact of miR-223-3p and miR-2909 on inflammatory factors IL-6, IL-1β, and TNF-α, and the TLR4/TLR2/NF-κB/STAT3 signaling pathway induced by lipopolysaccharide in human adipose stem cells

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miR-15b-5p ameliorated high glucose-induced podocyte injury through repressing apoptosis, oxidative stress, and inflammatory responses by targeting Sema3A

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Overexpression miR-24-3p repressed Bim expression to confer tamoxifen resistance in breast cancer

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Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma

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miR-214-5p inhibits human prostate cancer proliferation and migration through regulating CRMP5

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CANCER BIOMARKERS (2019)

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Article Oncology

Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer

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LncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis

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MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte

Guo-xing Wan et al.

CARDIOVASCULAR TOXICOLOGY (2019)

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Article Biochemistry & Molecular Biology

MiR-214 prevents the progression of diffuse large B-cell lymphoma by targeting PD-L1

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CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

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Article Biochemistry & Molecular Biology

miR-214 inhibits epithelial-mesenchymal transition of breast cancer cells via downregulation of RNF8

Lu Min et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2019)

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Downregulated miR-17, miR-29c, miR-92a and miR-214 may be related to BCL11B overexpression in Tcell acute lymphoblastic leukemia

Zifan He et al.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)

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Cost-utility analysis of fracture risk assessment using microRNAs compared with standard tools and no monitoring in the Austrian female population

Evelyn Walter et al.

BONE (2018)

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miR-214 reduces cisplatin resistance by targeting netrin-1 in bladder cancer cells

Jiao Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

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Review Biochemistry & Molecular Biology

MicroRNA Regulation of RNA Virus Replication and Pathogenesis

Derek W. Trobaugh et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma

Francisca Dias et al.

ONCOTARGET (2017)

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Downregulation of miR-214-3p May Contribute to Pathogenesis of Ulcerative Colitis via Targeting STAT6

Jin-an Li et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D

Yang Liu et al.

TUMOR BIOLOGY (2016)

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microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB

Keith M. Giles et al.

ONCOTARGET (2016)

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Review Biochemistry & Molecular Biology

The role of MicroRNAs in human cancer

Yong Peng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2016)

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Review Oncology

miR-214: a potential biomarker and therapeutic for different cancers

Tanu Sharma et al.

FUTURE ONCOLOGY (2015)

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microRNAs for peripheral blood fraction identification: Origin, pathways and forensic relevance

Maria Teresa Machado et al.

LIFE SCIENCES (2015)

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Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

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VIRUS RESEARCH (2015)

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Lipid-based mRNA vaccine delivery systems

Patrick Midoux et al.

EXPERT REVIEW OF VACCINES (2015)

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Impact of microRNA regulation on variation in human gene expression

Jian Lu et al.

GENOME RESEARCH (2012)

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MicroRNA: Biogenesis, Function and Role in Cancer

Leigh-Ann MacFarlane et al.

CURRENT GENOMICS (2010)

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Review Oncology

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

Richard Hummel et al.

EUROPEAN JOURNAL OF CANCER (2010)

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Review Biochemistry & Molecular Biology

MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

William C. S. Cho

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

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Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

F Li et al.

SCIENCE (2005)

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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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