期刊
CELLS
卷 11, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/cells11152279
关键词
COVID-19; vaccine; miRNAs; immune response; cancer
类别
资金
- Portuguese national funding agency for science, research and technology (FCT-Fundacao para a Ciencia e a Tecnologia) [UIDP/00776/2020]
- [UIDP/00776/2020-4B]
- Fundação para a Ciência e a Tecnologia [UIDP/00776/2020] Funding Source: FCT
This article discusses miRNAs related to SARS-CoV-2 that are dysregulated in cancer and may impact the immune response to vaccines. The authors propose seven potential miRNAs as prognostic biomarkers for stratifying cancer patients, aiding in personalized treatment.
Coronavirus disease (COVID-19) is an infectious disease that is caused by a highly contagious and severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). This infection started to spread across the world in 2019 and rapidly turned into a global pandemic, causing an urgent necessity for treatment strategies development. The mRNA vaccines against SARS-CoV-2 can trigger an immune response, providing genetic information that allows the production of spike glycoproteins. MiRNAs play a crucial role in diverse key cellular processes, including antiviral defense. Several miRNAs are described as key factors in SARS-CoV-2 human infection through the regulation of ACE2 levels and by the inhibition of SARS-CoV-2 replication and spike expression. Consequently, these molecules have been considered as highly promising biomarkers. In numerous human malignancies, it has been recognized that miRNAs expression is dysregulated. Since miRNAs can target SARS-CoV-2-associated mRNAs, in cancer patients, the deregulation of these molecules can impair the immune response to the vaccines. Therefore, in this review, we propose a miRNA profile of seven SARS-CoV-2-related miRNAs, namely miR-214, miR-98-5p, miR-7-5p, miR-24-3p, miR-145-5p, miR-223-3p and miR-15b-5p, that are deregulated in a high number of cancers and have the potential to be used as prognostic biomarkers to stratify cancer patients.
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