期刊
CELLS
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells11121953
关键词
centromere; diversity; satellite DNA; macaque; primate
类别
资金
- Center for Advanced Studies in Tropical Natural Resources, National Research University-Kasetsart University (CASTNAR, NRU-KU, Thailand)
- e-ASIA Joint Research Program [P1851131]
- National Science and Technology Development Agency (NSTDA) [NSTDA P-19-52238]
- Graduate Scholarship Program of the Graduate School, Kasetsart University, Thailand
- Thailand Research Fund-Chinese Academy of Science [DBG608008]
- Thailand Research Fund [RTA6280010]
- National Primate Research Center of Thailand-Chulalongkorn University (NPRCT-CU)
This study investigated the genetic diversity in the centromeric region of long-tailed and rhesus macaques, revealing diverse subfamilies and interspecific variability. The study also found admixture patterns and high level polymorphisms within populations.
Centromeric satellite DNA (cen-satDNA) consists of highly divergent repeat monomers, each approximately 171 base pairs in length. Here, we investigated the genetic diversity in the centromeric region of two primate species: long-tailed (Macaca fascicularis) and rhesus (Macaca mulatta) macaques. Fluorescence in situ hybridization and bioinformatic analysis showed the chromosome-specific organization and dynamic nature of cen-satDNAsequences, and their substantial diversity, with distinct subfamilies across macaque populations, suggesting increased turnovers. Comparative genomics identified high level polymorphisms spanning a 120 bp deletion region and a remarkable interspecific variability in cen-satDNA size and structure. Population structure analysis detected admixture patterns within populations, indicating their high divergence and rapid evolution. However, differences in cen-satDNA profiles appear to not be involved in hybrid incompatibility between the two species. Our study provides a genomic landscape of centromeric repeats in wild macaques and opens new avenues for exploring their impact on the adaptive evolution and speciation of primates.
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