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DEVELOPMENTAL DYNAMICS (2007)
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Adrian P. Bracken et al.
GENES & DEVELOPMENT (2007)
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
Melissa Dumble et al.
BLOOD (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the Arf tumor suppressor
J. Derek Thornton et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
Wei-Jian Guo et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
pRB family proteins are required for H3K27 trimethylation and polycomb repression complexes binding to and silencing p16(INK4a) tumor suppressor gene
Yojiro Kotake et al.
GENES & DEVELOPMENT (2007)
A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord
Hongxing Gui et al.
DEVELOPMENTAL BIOLOGY (2007)
The inhibition of T-cells proliferation by mouse mesenchymal stem cells through the induction of p16(INK4A)-cyclin D1/cdk4 and p21(waf1), p27(kip1)-cyclin E/cdk2 pathways
Jeong-A Kim et al.
CELLULAR IMMUNOLOGY (2007)
Polycomb silencing mechanisms and the management of genomic programmes
Yuri B. Schwartz et al.
NATURE REVIEWS GENETICS (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Control of the p53-p21CIP1 axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation
Nidhi Sharma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Polycomb silencers control cell fate, development and cancer
Anke Sparmann et al.
NATURE REVIEWS CANCER (2006)
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Viktor Janzen et al.
NATURE (2006)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
The tumor suppressor p16Ink4a regulates T lymphocyte survival
T. Bianchi et al.
ONCOGENE (2006)
Role of INK4a locus in normal eye development and cataract genesis
Cheolho Cheong et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Increased p53 activity does not accelerate telomere-driven ageing
I García-Cao et al.
EMBO REPORTS (2006)
The quail mesonephros: A new model for renal senescence?
Victor Nacher et al.
JOURNAL OF VASCULAR RESEARCH (2006)
The ARF tumour suppressor
Stuart J. Gallagher et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all
Jesus Gil et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Co-expression of p16INK4A and Laminin 5 by keratinocytes:: A wound-healing response coupling hypermotility with growth arrest that goes awry during epithelial neoplastic progression
E Natarajan et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2005)
Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye
RLA Silva et al.
EMBO JOURNAL (2005)
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
EL Denchi et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
J Seoane et al.
CELL (2004)
Modulation of mammalian life span by the short isoform of p53
B Maier et al.
GENES & DEVELOPMENT (2004)
Living with or without cyclins and cyclin-dependent kinases
CJ Sherr et al.
GENES & DEVELOPMENT (2004)
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
A Matheu et al.
GENES & DEVELOPMENT (2004)
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics
A Aslanian et al.
GENES & DEVELOPMENT (2004)
p19ARF directly and differentially controls the functions of c-Myc independently of p53
Y Qi et al.
NATURE (2004)
Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the Arf tumor suppressor gene
AC Martin et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2004)
p19ARF-induced p53-independent apoptosis largely occurs through BAX
H Suzuki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Defective endochondral ossification in mice with strongly compromised expression of JunB
J Hess et al.
JOURNAL OF CELL SCIENCE (2003)
Reversal of human cellular senescence:: roles of the p53 and p16 pathways
CM Beauséjour et al.
EMBO JOURNAL (2003)
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
IK Park et al.
NATURE (2003)
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
I García-Cao et al.
EMBO JOURNAL (2002)
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
J Seoane et al.
NATURE (2002)
Negative regulation of the mammalian UV response by Myc through association with Miz-1
S Herold et al.
MOLECULAR CELL (2002)
The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction
KD Wagner et al.
FASEB JOURNAL (2002)
The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development
RN McKeller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
p53 mutant mice that display early ageing-associated phenotypes
SD Tyner et al.
NATURE (2002)
The E2F1-3 transcription factors are essential for cellular proliferation
LZ Wu et al.
NATURE (2001)
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
P Krimpenfort et al.
NATURE (2001)
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
NE Sharpless et al.
NATURE (2001)
Modulation of the expression of the Cip/Kip family of cyclin-dependent kinase inhibitors in foetal developing lungs of hamsters
T Ikomo et al.
CELL PROLIFERATION (2001)
The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells
JL Lewis et al.
BLOOD (2001)
p53-independent functions of the p19ARF tumor suppressor
JD Weber et al.
GENES & DEVELOPMENT (2000)
Downregulation of 14-3-3σ prevents clonal evolution and leads to immortalization of primary human keratinocytes
E Dellambra et al.
JOURNAL OF CELL BIOLOGY (2000)
p16INK4a can initiate an autonomous senescence program
CY Dai et al.
ONCOGENE (2000)
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