期刊
CELLS
卷 11, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/cells11132050
关键词
immunoscore; CD8; FoxP3; CD68; head and neck cancer; prognosis; tumor microenvironment; tumor infiltration
类别
资金
- University of Mons
- Walloon Region via the ProtherWal society [7289]
- EpiCURA Hospital
By assessing immune cell infiltrates, an immunoscore can be developed for prognosis in head and neck cancer patients, with the combination of CD8, FoxP3, and CD68 immunoscore showing a significant association with overall survival.
We assessed immune cell infiltrates to develop an immunoscore for prognosis and to investigate its correlation with the clinical data of patients with head and neck cancer. CD8, FoxP3, and CD68 markers were evaluated by immunohistochemistry in 258 carcinoma samples and positive cells were counted in stromal and intra-tumoral compartments. The RStudio software was used to assess optimal cut-offs to divide the population according to survival while the prognostic value was established by using Kaplan-Meier curves and Cox regression models for each immune marker alone and in combination. We found with univariate analysis that the infiltration of immune cells in both compartments was predictive for recurrence-free survival and overall survival. Multivariate analysis revealed that CD8+ density was an independent prognostic marker. Additionally, the combination of CD8, FoxP3, and CD68 in an immunoscore provided a significant association with overall survival (p = 0.002, HR = 9.87). Such an immunoscore stayed significant (p = 0.018, HR = 11.17) in a multivariate analysis in comparison to tumor stage and histological grade, which had lower prognostic values. Altogether, our analysis indicated that CD8, FoxP3, and CD68 immunoscore was a strong, independent, and significant prognostic marker that could be introduced into the landscape of current tools to improve the clinical management of head and neck cancer patients.
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