期刊
CELLS
卷 11, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/cells11142224
关键词
lipid metabolism; neutral lipids; lipid droplets; DNA viral infections
类别
资金
- ANID-Millennium Science Initiative Program [ICN09_016]
- Millennium Institute on Immunology and Immunotherapy [ICN09_016/ICN 2021_045]
- FONDECYT from ANID [1190864, 1190830]
- Regional Government of Antofagasta through the Innovation Fund for Competitiveness FICR 2017 (BIP) [30488811-0]
- PATH
- 3M-Globalgiving
- ANID [21191390, 21221163]
This article reviews and discusses the interplay between neutral lipid metabolism and lipid droplets (LDs) in the replication cycle of different DNA viruses. It highlights the role of LDs in modulating viral infection and identifies potentially new molecular targets for the treatment of viral infections.
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and cholesterol esters that are coated by a phospholipid monolayer and associated proteins. LDs are known to play important roles in the storage and availability of lipids in the cell and to serve as a source of energy reserve for the cell. However, these structures have also been related to oxidative stress, reticular stress responses, and reduced antigen presentation to T cells. Importantly, LDs are also known to modulate viral infection by participating in virus replication and assembly. Here, we review and discuss the interplay between neutral lipid metabolism and LDs in the replication cycle of different DNA viruses, identifying potentially new molecular targets for the treatment of viral infections.
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