期刊
CELLS
卷 11, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/cells11142163
关键词
acute phase response; acute phase proteins; insulin resistance; type II diabetes; glucocorticoids; pro-inflammatory cytokines
类别
资金
- Medical Research Council of South Africa
Acute phase proteins (APPs) such as PAI-1, SAA, and CRP are elevated in type-2 diabetes and may be the causal link between stress, inflammation, and the development of insulin resistance.
Acute phase proteins (APPs), such as plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), and C-reactive protein (CRP), are elevated in type-2 diabetes (T2D) and are routinely used as biomarkers for this disease. These APPs are regulated by the peripheral mediators of stress (i.e., endogenous glucocorticoids (GCs)) and inflammation (i.e., pro-inflammatory cytokines), with both implicated in the development of insulin resistance, the main risk factor for the development of T2D. In this review we propose that APPs, PAI-1, SAA, and CRP, could be the causative rather than only a correlative link between the physiological elements of risk (stress and inflammation) and the development of insulin resistance.
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