Exonucleases: Degrading DNA to Deal with Genome Damage, Cell Death, Inflammation and Cancer

Although DNA degradation might seem an unwanted event, it is essential in many cellular processes that are key to maintaining genomic stability and cell and organism homeostasis. The capacity to cut out nucleotides one at a time from the end of a DNA chain is present in enzymes called exonucleases. Exonuclease activity might come from enzymes with multiple other functions or specialized enzymes only dedicated to this function. Exonucleases are involved in central pathways of cell biology such as DNA replication, repair, and death, as well as tuning the immune response. Of note, malfunctioning of these enzymes is associated with immune disorders and cancer. In this review, we will dissect the impact of DNA degradation on the DNA damage response and its links with inflammation and cancer.

Automated summary

DNA degradation plays a crucial role in maintaining genomic stability and cellular homeostasis. Exonucleases, enzymes capable of removing nucleotides from the end of a DNA chain, are involved in vital cellular processes such as DNA replication, repair, and immune response regulation. Dysfunctions in these enzymes are associated with immune disorders and cancer.