期刊
CELLS
卷 11, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/cells11152310
关键词
adipose tissue; obesity; mechanobiology
类别
资金
- Fondation pour la Recherche Medicale (FRM) [FDT201904008276, FDT202106012793]
Adipose tissue expansion is an adaptive mechanism that increases nutrient buffering capacity. However, remodeling of adipose tissue, characterized by adipocyte hypertrophy, immune cells infiltration, fibrosis, and changes in vascular architecture, generates mechanical stress on adipose cells. This mechanical stimulus alters adipose function through mechanotransduction, leading to obesity-associated dysfunction in adipose tissue.
The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering capacity in response to an overall positive energy balance. Over the course of expansion, the adipose microenvironment undergoes continual remodeling to maintain its structural and functional integrity. However, in the long run, adipose tissue remodeling, typically characterized by adipocyte hypertrophy, immune cells infiltration, fibrosis and changes in vascular architecture, generates mechanical stress on adipose cells. This mechanical stimulus is then transduced into a biochemical signal that alters adipose function through mechanotransduction. In this review, we describe the physical changes occurring during adipose tissue remodeling, and how they regulate adipose cell physiology and promote obesity-associated dysfunction in adipose tissue.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据