☆ 4.6 Review

Progress and Setbacks in Translating a Decade of Ferroptosis Research into Clinical Practice

CELLS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

The multifaceted role of ferroptosis in liver disease

Junyi Chen et al.

Summary: Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and is associated with liver diseases. Dysregulated metabolic pathways and impaired iron homeostasis play a role in the progression of liver disease via ferroptosis. Several ferroptosis-associated genes and pathways have been implicated in liver disease. Targeting ferroptosis may have therapeutic potential for managing liver diseases.

CELL DEATH AND DIFFERENTIATION (2022)

添加到收藏夹

Article Cell Biology

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Hai-Liang Zhang et al.

Summary: Through CRISPR-Cas9 and kinase inhibitor screening, Zhang et al. found that PKC beta II phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

NATURE CELL BIOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Clinical use of N-acetyl cysteine during liver transplantation: Implications of oxidative stress and inflammation as therapeutic targets

Yonela Ntamo et al.

Summary: Liver transplantation is the definitive treatment for complete liver failure, but oxidative stress and inflammation contribute to the damage caused during the procedure. N-acetyl cysteine (NAC) has been studied as a potential therapeutic drug to counteract oxidative stress and inflammation. Clinical evidence suggests that NAC can improve liver function by enhancing endogenous antioxidants and attenuating inflammation, but some studies have shown conflicting results.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Epidemiology of cardiovascular disease in Europe

Nick Townsend et al.

Summary: This review highlights the significant health burden of cardiovascular disease (CVD) in the WHO European Region, with CVD being the leading cause of death in the region. Men have higher age-standardized rates of morbidity and death from CVD compared to women, particularly in individuals under 70 years of age. Improving surveillance and monitoring, as well as implementing evidence-based preventive and treatment approaches, are essential to address the large inequalities in CVD outcomes across countries in Europe.

NATURE REVIEWS CARDIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury

Jing Mu et al.

Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury

Benedikt Kolbrink et al.

Summary: Ferroptosis, a type of iron-dependent programmed cell death, plays a vital role in multiple diseases. However, there are no pharmacologic inhibitors of ferroptosis in clinical use. In this study, vitamin K1 was identified as an efficient inhibitor of ferroptosis, providing a new strategy for pharmacological control of this mode of cell death.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

添加到收藏夹

Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Jean-Philippe Collet et al.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease

Wen-Dai Bao et al.

Summary: Iron homeostasis disturbance and ferroptosis play critical roles in the pathogenesis and progression of Alzheimer's disease, and targeting these processes may provide promising therapeutic approaches for this disease.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

Lohans Pedrera et al.

Summary: Ferroptosis is a form of regulated necrosis that depends on iron ions and is associated with lipid peroxidation. An increase in cytosolic Ca2+ precedes cell bursting in ferroptosis, and membrane nanopores are linked to plasma membrane damage in this process. Activation of ESCRT-III serves as a general protective mechanism, counterbalancing cell death kinetics during ferroptosis.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary A Report of the AAN Guideline Subcommittee

Tamara Pringsheim et al.

Summary: The review found that initial treatment with levodopa provides better motor benefits compared to dopamine agonists, but is also more likely to cause motor complications. There was little evidence to suggest that any particular formulation or method of administration of dopamine agonists is superior. Long-acting forms of levodopa and combination formulations with entacapone do not appear to differ in efficacy from immediate-release levodopa for early disease motor symptoms. Patients using dopamine agonists may have a higher risk of impulse control disorders compared to those using levodopa.

NEUROLOGY (2021)

添加到收藏夹

Article Peripheral Vascular Disease

Worldwide Trends in Prevalence, Mortality, and Disability-Adjusted Life Years for Hypertensive Heart Disease From 1990 to 2017

Haijiang Dai et al.

Summary: The prevalence of hypertensive heart disease (HHD) has been increasing globally from 1990 to 2017, while the mortality and disability-adjusted life year rates have shown a decrease. Female gender and older age are associated with higher prevalence rates of HHD, while there is a negative correlation between Sociodemographic index and disability-adjusted life year rates.

HYPERTENSION (2021)

添加到收藏夹

Review Medicine, General & Internal

Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

Ruta Zulpaite et al.

Summary: Kidney transplantation is the gold standard treatment for patients with end-stage kidney disease, but the quality of donor organs poses limitations. Ex-vivo machine perfusion technology has great potential in maintaining kidney viability and optimizing organ treatment, serving as an important component of novel techniques in transplant surgery.

FRONTIERS IN MEDICINE (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

N-Acetylcysteine for Cardiac Protection During Coronary Artery Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sher Ali Khan et al.

Summary: Reperfusion is essential for managing symptoms in patients with myocardial ischemia, but it can lead to paradoxical injury. The use of N-acetylcysteine (NAC) has shown promise in reducing reactive oxygen species (ROS) and improving clinical outcomes in patients undergoing coronary artery reperfusion procedures. Meta-analysis of randomized controlled trials (RCTs) suggests that NAC administration during or prior to reperfusion may decrease serum cardiac troponin levels and the incidence of postoperative atrial fibrillation, providing supportive evidence for the potential benefit of NAC as adjunct therapy for cardiac protection against reperfusion injury.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

添加到收藏夹

Review Cell Biology

Regulated cell death pathways in doxorubicin-induced cardiotoxicity

Effimia Christidi et al.

Summary: This review summarizes recent advances in understanding the mechanisms by which Doxorubicin induces cardiomyocyte death, including pathways such as autophagy, ferroptosis, necroptosis, pyroptosis, and apoptosis. Understanding these mechanisms may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

Christina M. Bebber et al.

Summary: The loss of TP53 and RB1 in treatment-naive small cell lung cancer (SCLC) indicates a need to inactivate cell death pathways prior to therapy. This study identifies non-neuroendocrine (NE) SCLC as vulnerable to ferroptosis and neuroendocrine (NE) SCLC as susceptible to TRX pathway inhibition, with combining these treatments showing promise in overcoming subtype plasticity in SCLC.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Medicine, General & Internal

Alzheimer disease

David S. Knopman et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive impairments. The pathophysiology involves a complex interplay of loss of synaptic homeostasis and dysfunction in endosomal/lysosomal clearance pathways. Therapeutic options are still being sought to substantially alter the clinical course of individuals with Alzheimer's disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Review Surgery

Machine Perfusion of the Liver: A Review of Clinical Trials

Nikolaos Serifis et al.

Summary: Efforts to increase the pool of available livers have led to the adoption of extended criteria for liver acceptance, however, this practice poses risks for recipients. Donor liver machine perfusion offers a promising strategy, with various techniques like hypothermic and normothermic machine perfusion showing potential in assessing graft viability. Studies on markers of viability and the potential for completely ischemia-free transplantation are ongoing, suggesting a promising future for the incorporation of machine perfusion into routine clinical practice.

FRONTIERS IN SURGERY (2021)

添加到收藏夹

Review Medicine, General & Internal

Liver cirrhosis

Pere Gines et al.

Summary: Cirrhosis is a widespread disease with various causes, leading to portal hypertension, systemic inflammation, and liver failure. Early diagnosis and management of complications are crucial to prevent progression to decompensated cirrhosis. Liver transplantation may be necessary in severe cases.

LANCET (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Ramon Rodrigo et al.

Summary: Post-PCI intravenous infusion of vitamin C can reduce cardiac injury biomarkers, inflammatory biomarkers, and ROS production, but its association with Vit C remains inconclusive. Therefore, combining other antioxidant agents may further enhance these beneficial effects.

MOLECULES (2021)

添加到收藏夹

Article Cell Biology

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis

Bo Zhang et al.

Summary: The study demonstrates the role of ferroptosis in renal fibrosis induced by unilateral ureteral obstruction. Inhibiting ferroptosis can alleviate the morphological and pathological changes of renal fibrosis and suppress the expression of profibrotic factors. Liproxstatin-1 may potentially be used as a therapeutic approach for UUO-induced renal fibrosis by inhibiting ferroptosis in renal tubular epithelial cells.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Medicine, General & Internal

Acute kidney injury

John A. Kellum et al.

Summary: Acute kidney injury (AKI) describes a sudden loss of kidney function which can lead to long term damage. AKI and AKD are global issues with different causes and management strategies in various regions. Prevention and early detection of AKI are crucial for better outcomes.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

添加到收藏夹

Article Critical Care Medicine

Mortality in septic patients treated with vitamin C: a systematic meta-analysis

Sean S. Scholz et al.

Summary: Despite no reduction in pooled mortality, potential benefits of administering vitamin C for 3-4 days in septic patients were observed. Further research is needed to identify patient subgroups that might benefit from intravenous supplementation of vitamin C.

CRITICAL CARE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

ROS in cancer therapy: the bright side of the moon

Bruno Perillo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

Naoya Yamada et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Cell Biology

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

Zhaoxin Hu et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Hematology

Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis

Yingying Yu et al.

BLOOD (2020)

添加到收藏夹

Article Urology & Nephrology

Donor Age, Cold Ischemia Time, and Delayed Graft Function

Ilkka Helantera et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Vanessa A. N. Kraft et al.

ACS CENTRAL SCIENCE (2020)

添加到收藏夹

Article Cell Biology

Transferrin Receptor Is a Specific Ferroptosis Marker

Huizhong Feng et al.

CELL REPORTS (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Sepsis-Induced Cardiomyopathy: a Comprehensive Review

Michael L'Heureux et al.

CURRENT CARDIOLOGY REPORTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Deirdre Nolfi-Donegan et al.

REDOX BIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Mariluz Soula et al.

NATURE CHEMICAL BIOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Theo Vos et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Yilong Zou et al.

NATURE (2020)

添加到收藏夹

Article Cell Biology

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

Michelle Riegman et al.

NATURE CELL BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish

Anushka Katikaneni et al.

NATURE CELL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Nandini Verma et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial

Piotr Ponikowski et al.

LANCET (2020)

添加到收藏夹

Article Oncology

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Article Urology & Nephrology

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

Mina Borran et al.

RENAL REPLACEMENT THERAPY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Cell Biology

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

Yilei Zhang et al.

CELL CYCLE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Drug-induced liver injury

Raul J. Andrade et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Review Urology & Nephrology

Regulated necrosis in kidney ischemia-reperfusion injury

Aspasia Pefanis et al.

KIDNEY INTERNATIONAL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Javier Garcia-Bermudez et al.

NATURE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

Yufei Wang et al.

EMBO REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

Melania Guerrero-Hue et al.

FASEB JOURNAL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

ACG Clinical Guideline: Hereditary Hemochromatosis

Kris V. Kowdley et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

Daniel A. Monti et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling

Jiao Wu et al.

NATURE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Xiaoqing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Article Medicine, General & Internal

Canadian guideline for Parkinson disease

David Grimes et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2019)

添加到收藏夹

Article Medicine, General & Internal

Drug-induced liver injury

Raul J. Andrade et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

添加到收藏夹

Article Cell Biology

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

Tae-Jun Park et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Medicine, General & Internal

Ischaemic stroke

Bruce C. Campbell et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Yansheng Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia

M. Grazia Cotticelli et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

添加到收藏夹

Article Oncology

The Interrelationship of Pharmacologic Ascorbate Induced Cell Death and Ferroptosis

Tamas Lorincz et al.

PATHOLOGY & ONCOLOGY RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

Bei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

Mingzhu Yan et al.

REDOX BIOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Haemochromatosis

Pierre Brissot et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

添加到收藏夹

Review Urology & Nephrology

Global epidemiology and outcomes of acute kidney injury

Eric A. J. Hoste et al.

NATURE REVIEWS NEPHROLOGY (2018)

添加到收藏夹

Article Clinical Neurology

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

Saravanan S. Karuppagounder et al.

ANNALS OF NEUROLOGY (2018)

添加到收藏夹

Article Urology & Nephrology

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

Diego Martin-Sanchez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

添加到收藏夹

Review Cell Biology

Necroptosis in development, inflammation and disease

Ricardo Weinlich et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Characterization of Ferroptosis in Murine Models of Hemochromatosis

Hao Wang et al.

HEPATOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Iron and Ferroptosis: A Still Ill-Defined Liaison

Sebastian Doll et al.

IUBMB LIFE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-z Tuo et al.

MOLECULAR PSYCHIATRY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

添加到收藏夹

Review Medicine, General & Internal

Acute Myocardial Infarction

Jeffrey L. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Article Clinical Neurology

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

Marietta Zille et al.

STROKE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

William Sealy Hambright et al.

REDOX BIOLOGY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Omkar Zilka et al.

ACS CENTRAL SCIENCE (2017)

添加到收藏夹

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson's disease

Antonio Martin-Bastida et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

Tammo Mueller et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment-Elevation Myocardial Infarction and Adverse Left Ventricular Remodeling

Heerajnarain Bulluck et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Metallothionein-1G Facilitates Sorafenib Resistance Through Inhibition of Ferroptosis

Xiaofang Sun et al.

HEPATOLOGY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Sam Hofmans et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Epidemiology and aetiology of heart failure

Boback Ziaeian et al.

NATURE REVIEWS CARDIOLOGY (2016)

添加到收藏夹

Article Neurosciences

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

Bruce Do Van et al.

NEUROBIOLOGY OF DISEASE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Surgery

Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers

Marco Cannistra et al.

INTERNATIONAL JOURNAL OF SURGERY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Meta-analysis of brain iron levels of Parkinson's disease patients determined by postmortem and MRI measurements

Jian-Yong Wang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

Liuji Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

添加到收藏夹

Article Oncology

Ferroptosis is Involved in Acetaminophen Induced Cell Death

Tamas Lorincz et al.

PATHOLOGY & ONCOLOGY RESEARCH (2015)

添加到收藏夹

Article Immunology

Effect of N-Acetylcysteine Pretreatment of Deceased Organ Donors on Renal Allograft Function: A Randomized Controlled Trial

Jean-Christophe Orban et al.

TRANSPLANTATION (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Joe Dan Dunn et al.

REDOX BIOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

David Devos et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Rachid Skouta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Immunology

Pulsatile Perfusion Reduces the Risk of Delayed Graft Function in Deceased Donor Kidney Transplants, Irrespective of Donor Type and Cold Ischemic Time

Jagbir Gill et al.

TRANSPLANTATION (2014)

添加到收藏夹

Review Critical Care Medicine

Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review

Nadezda Petejova et al.

CRITICAL CARE (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress and the Use of Antioxidants in Stroke

Rachel Shirley et al.

ANTIOXIDANTS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

Tohru Yamamori et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

添加到收藏夹

Review Toxicology

Drug-Induced Oxidative Stress and Toxicity

Damian G. Deavall et al.

JOURNAL OF TOXICOLOGY (2012)

添加到收藏夹

Review Chemistry, Multidisciplinary

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

Jesper Z. Haeggstrom et al.

CHEMICAL REVIEWS (2011)

添加到收藏夹

Article Urology & Nephrology

Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure

Andreas Linkermann et al.

KIDNEY INTERNATIONAL (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

A Phase 1/2, Dose-Escalation Trial of Deferasirox for the Treatment of Iron Overload in HFE-Related Hereditary Hemochromatosis

Pradyumna Phatak et al.

HEPATOLOGY (2010)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Magnetic Resonance Imaging Quantification of Liver Iron

Claude B. Sirlin et al.

MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA (2010)

添加到收藏夹

Article Medicine, General & Internal

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency.

Stefan D. Anker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Urology & Nephrology

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Asli Korkmaz et al.

RENAL FAILURE (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

Wan Seok Yang et al.

CHEMISTRY & BIOLOGY (2008)

添加到收藏夹

Review Medicine, General & Internal

Vitamin E for Alzheimer's disease and mild cognitive impairment

Mokhtar Gad El Kareem Nasr Isaac et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Vitamin C and vitamin E for Alzheimer's disease

LA Boothby et al.

ANNALS OF PHARMACOTHERAPY (2005)

添加到收藏夹

Article Medicine, General & Internal

Dietary intake of antioxidants and risk of Alzheimer disease

MJ Engelhart et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

添加到收藏夹

Review Multidisciplinary Sciences

Apoptosis in development

P Meier et al.

NATURE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.