期刊
CELLS
卷 11, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/cells11142260
关键词
hedgehog signaling pathway; oligodendrocytes; remyelination; multiple sclerosis
类别
资金
- National Natural Science Foundation of China [82101244, 32170969]
- Brain Initiative Grant of the Ministry of Science and Technology, China [2022ZD0204701]
Remyelination is a crucial repair process in the central nervous system, but it often fails in demyelinating diseases. The Hedgehog signaling pathway is a key regulatory target for myelin regeneration, although its exact mechanisms are still not fully understood.
Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional impairment. While spontaneous remyelination often fails in the progression of demyelinating diseases, increased understanding of the mechanisms and identification of targets that regulate myelin regeneration becomes crucial. To date, several signaling pathways have been implicated in the remyelination process, including the Hedgehog (Hh) signaling pathway. This review summarizes the current data concerning the complicated roles of the Hh signaling pathway in the context of remyelination. We will highlight the open issues that have to be clarified prior to bringing molecules targeting the Hh signaling to demyelinating therapy.
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