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Human Milk Extracellular Vesicles: A Biological System with Clinical Implications

CELLS (2022)

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Review Food Science & Technology

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

Carolina de Weerth et al.

Summary: Human milk is a complex liquid food that is customized to meet the needs of infants. The non-nutrient bioactives in milk have an impact on child cognitive and behavioral development, a process known as 'Lactocrine Programming'. This review discusses the links between human milk composition and child cognitive and behavioral development, and provides recommendations for future studies.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Article Pharmacology & Pharmacy

Gestational Diabetes Mellitus Is Associated with Altered Abundance of Exosomal MicroRNAs in Human Milk

Kruti B. Shah et al.

Summary: The study examined the impact of gestational diabetes mellitus (GDM) on microRNA (miRNA) abundance in human milk and its association with infant body composition during the first 6 months of life. The results showed that GDM mothers had reduced abundance of certain miRNAs in their milk. Additionally, higher maternal diet quality was positively associated with increased miRNA abundance. Some miRNAs were also found to be associated with infant weight and fat mass.

CLINICAL THERAPEUTICS (2022)

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Article Environmental Sciences

Maternal and Childhood Ambient Air Pollution Exposure and Mental Health Symptoms and Psychomotor Development in Children: An Australian Population-Based Longitudinal Study

Salma M. Ahmed et al.

Summary: The study found that exposure to moderate and high levels of PM2.5 was associated with increased risk of emotional and behavioral problems, and gross motor delay in children. However, there was insufficient evidence to suggest that NO2 exposure or living near major roads was associated with children's emotional and behavioral problems or developmental delay.

ENVIRONMENT INTERNATIONAL (2022)

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Article Cell Biology

Human Breast Milk-Derived Exosomal miR-148a-3p Protects Against Necrotizing Enterocolitis by Regulating p53 and Sirtuin 1

Miao-miao Guo et al.

Summary: The miR-148a-3p/p53/SIRT1 axis has a considerable protective effect on NEC, and agomir therapy provides a new treatment strategy for NEC.

INFLAMMATION (2022)

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Article Neurosciences

Cerebrospinal Fluid Extracellular Vesicles with Distinct Properties in Autoimmune Encephalitis and Herpes Simplex Encephalitis

Yongang Li et al.

Summary: This study examined the role of cerebrospinal fluid (CSF) exosomes from patients with autoimmune encephalitis (AE) and herpes simplex encephalitis (HSE). The study found specific miRNAs highly expressed in AE patients and higher exosome concentration in CSF of HSE patients. Furthermore, the research suggests that HSV may trigger brain autoimmunity in HSE through the presentation of surface autoantigens via exosomes.

MOLECULAR NEUROBIOLOGY (2022)

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Review Instruments & Instrumentation

Exosomal targeting and its potential clinical application

Jiao He et al.

Summary: Exosomes, as extracellular vesicles secreted by living cells, possess natural targeting as nano-carriers for drug delivery systems. However, the natural targeting alone is insufficient for precise delivery, requiring engineering transformation and modification to optimize targeting efficiency.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Human Milk Oligosaccharides: Potential Applications in COVID-19

Somchai Chutipongtanate et al.

Summary: This review summarizes the potential role and application prospects of human milk oligosaccharides (hMOS) in COVID-19, discusses the possible mechanisms of action of hMOS in different stages of SARS-CoV-2 infection, and describes the challenges and opportunities of hMOS research for clinical applications.

BIOMEDICINES (2022)

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Review Cell Biology

Milk exosomes in nutrition and drug delivery

Alice Ngu et al.

Summary: Exosomes are natural nanoparticles that play an important role in cell-to-cell communication by transferring RNA, lipids, and proteins. They have high concentration and resistance to degradation in milk. Milk exosomes have the potential to be novel bioactive food compounds and drug carriers, which has attracted significant interest and research in nutrition and pharmacology fields.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Milk-Derived Exosomes as Nanocarriers to Deliver Curcumin and Resveratrol in Breast Tissue and Enhance Their Anticancer Activity

Antonio Gonzalez-Sarrias et al.

Summary: This study compared the delivery and anticancer activity of free curcumin and resveratrol with their encapsulation in milk-derived EXOs in breast tissue and breast cancer cell lines. The results demonstrated that milk EXOs enhanced the bioavailability and anticancer activity of curcumin and resveratrol, providing a promising approach for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, Research & Experimental

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease

Li Zeng et al.

Summary: This study revealed the important role and mechanism of miR-148a-3p in Alzheimer's disease, which protects neuronal cells against tau hyperphosphorylation by regulating the p35/CDK5 and PTEN/p38 MAPK pathways. Moreover, a mutual regulatory link between miR-148a-3p and PTEN was confirmed through the promotion of transcription and expression, suggesting their essential contribution to AD pathology.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Oncology

Extracellular Vesicle-Based Method for Detecting MYCN Amplification Status of Pediatric Neuroblastoma

Jirawan Panachan et al.

Summary: This study aimed to establish a less invasive method to detect the MYCN status in pediatric neuroblastoma (NB) based on the content of MYCN mRNA in extracellular vesicles (EVs). The study successfully detected MYCN mRNA in microvesicles (MVs) of MYCN-amplified NB cells. The feasibility of the EV-based method was demonstrated using simulated samples and clinical specimens, showing promising results.

CANCERS (2022)

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Letter Cell Biology

Anti-SARS-CoV-2 effect of extracellular vesicles released from mesenchymal stem cells

Somchai Chutipongtanate et al.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Nutrition & Dietetics

Small Extracellular Vesicles in Milk Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice

Fang Zhou et al.

Summary: This study assessed the transportation of sEVs across the blood-brain barrier and their accumulation in the brain, as well as their effects on neuronal development, spatial learning and memory, and resistance to kainic acid-induced seizures in mice. The findings suggest that sEVs play a crucial role in these processes.

FRONTIERS IN NUTRITION (2022)

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Review Biochemistry & Molecular Biology

The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer

Manal A. Babaker et al.

Summary: Colorectal cancer is a prevalent and deadly form of cancer. Current chemotherapy treatments are not selective, causing harm to healthy cells. Milk-derived extracellular vesicles offer potential as a natural alternative with the ability to suppress tumor cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Hematology

Extracellular vesicles from amniotic fluid, milk, saliva, and urine expose complexes of tissue factor and activated factor VII

Yong Hu et al.

Summary: This study found that extracellular vesicles (EVs) in amniotic fluid, milk, saliva, and urine expose functional extrinsic tenase complexes that can trigger blood clotting. These EVs promote clotting in both normal plasma and FVII-deficient plasma, and their activity is inhibited by antibodies.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Review Cell Biology

Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis

Rosa Suades et al.

Summary: Atherosclerotic cardiovascular disease is a major global health threat. Extracellular vesicles play important roles in its development, both negatively by causing vascular dysfunction and inflammation, and positively through promoting vascular repair and anti-inflammatory effects.

CELLS (2022)

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Review Biochemistry & Molecular Biology

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Yolanda Olmos

Summary: This article reviews the molecular mechanisms of membrane constriction and scission by ESCRT-III and describes its essential role in sealing and repairing damaged cellular membranes.

MEMBRANES (2022)

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Article Pediatrics

Active free secretory component and secretory IgA in human milk: do maternal vaccination, allergy, infection, mode of delivery, nutrition and active lifestyle change their concentrations?

Veronique Demers-Mathieu et al.

Summary: Active free secretory component (free SC) in human milk, a critical constituent of SIgA, is more impacted by maternal factors such as vaccination during pregnancy, allergy, nutrition, type of delivery and lifestyle. The concentration of free SC varies significantly among mothers.

PEDIATRIC RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Associations between maternal lifetime stressors and negative events in pregnancy and breast milk-derived extracellular vesicle microRNAs in the programming of intergenerational stress mechanisms (PRISM) pregnancy cohort

Anne K. Bozack et al.

Summary: Maternal lifetime stress and negative life events during pregnancy are associated with detection and expression levels of breast milk extracellular vesicle microRNAs. These microRNAs are linked to biological pathways such as fatty acid metabolism and the Hippo signaling pathway. Further research is needed to identify the impact of these microRNAs on child health outcomes.

EPIGENETICS (2021)

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Article Neurosciences

Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis

Yiwen Huang et al.

Summary: In this study, it was found that post-ischemic stroke, HOTAIR absorbed miR-148a3p and upregulated KLF6 expression, promoting apoptosis and inflammation, exacerbating neurological injury.

BRAIN RESEARCH BULLETIN (2021)

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Article Biochemistry & Molecular Biology

Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy

Lorena del Pozo-Acebo et al.

Summary: miRNAs are potential mediators of gene expression in therapeutic strategies, but the instability of extracellular RNAs limits their biological function. Strategies to enhance miRNA therapeutic potential include developing efficient, tissue-specific delivery methods using exosomes. However, a standard, reproducible, and cost-effective protocol for exosome isolation and extracellular RNA delivery is currently lacking.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Obstetrics & Gynecology

The impact of maternal obesity on childhood neurodevelopment

Lilin Tong et al.

Summary: Maternal obesity may increase children's susceptibility to neurodevelopmental and neuropsychiatric disorders. Key mechanisms such as inflammation, alterations to the microbiome, epigenetic modifications, and impaired signaling pathways have been identified. Proposed interventions and future research priorities include addressing these mechanisms and knowledge gaps.

JOURNAL OF PERINATOLOGY (2021)

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Article Developmental Biology

Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth

Jiayi Jiang et al.

Summary: The study found that SNHG29 was overexpressed in placentas from women who delivered preterm with labor and in HTR8/SVneo cells treated with H2O2. High levels of SNHG29 promoted cell senescence, potentially affecting the pathophysiology of spontaneous preterm birth.

PLACENTA (2021)

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Review Obstetrics & Gynecology

Outcomes improved with human milk intake in preterm and full-term infants

Katherine E. Chetta et al.

Summary: Human milk has significant effects on the gut microbiome, somatic growth, and neurocognitive outcomes. Continued research promises to improve donor human milk and donor milk derived products to achieve better outcomes for infants who do not receive their own mother's milk. The promotion of human milk is well-founded on evidence from the previous half century.

SEMINARS IN PERINATOLOGY (2021)

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Article Medicine, Research & Experimental

lncRNA NORAD is consistently detected in breastmilk exosomes and its expression is downregulated in mothers of preterm infants

Niki Mourtzi et al.

Summary: This study found that lncRNAs in breast milk may play an important role in early human development, with generally higher levels of lncRNAs in the milk of mothers who gave birth at term compared to those who gave birth prematurely. The presence of lncRNAs in human breast milk could explain the consistent inability of researchers to fully 'humanize' animal milk.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Nursing

Human Colostrum and Derived Extracellular Vesicles Prevent Infection by Human Rotavirus and Respiratory Syncytial Virus in Vitro

Andrea Civra et al.

Summary: The study found significant antiviral activity of human colostrum against rotavirus and respiratory syncytial virus, with extracellular vesicles interfering with early steps of viral replication. This contributes to understanding novel mechanisms of human milk as a protective and therapeutic agent in preterm infants.

JOURNAL OF HUMAN LACTATION (2021)

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Article Pediatrics

Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant

Margaret G. Parker et al.

Summary: Providing mother's own milk for hospitalized very low birth weight infants in the NICU has short- and long-term health benefits. When mother's own milk is not available, pasteurized human donor milk is recommended as an alternative. Neonatal health care providers can support lactation in the NICU to reduce disparities in provision of mother's own milk.

PEDIATRICS (2021)

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Article Multidisciplinary Sciences

The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey

Kun A. Susiloretni et al.

Summary: Parental psychological distress is associated with reduced linear growth and stunting in children, with factors such as socioeconomic status, physiological factors, behavioral factors, and infectious diseases playing a role in stunting. The study suggests that nutritional and biomedical interventions alone are insufficient, and emphasizes the importance of mental and behavioral health programs for parents in enhancing child growth and development.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Comparison of methods for pre-processing, exosome isolation, and RNA extraction in unpasteurized bovine and human milk

Sanoji Wijenayake et al.

Summary: This study tested various preprocessing methods, exosome isolation techniques, and RNA extraction protocols to improve and optimize the isolation and characterization of milk-derived exosomes.

PLOS ONE (2021)

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Article Biochemical Research Methods

Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size

Thanh Kha Phan et al.

Summary: Apoptotic bodies (ApoBDs) are large extracellular vesicles released exclusively by apoptotic cells, possessing therapeutically exploitable properties. The PANX1 channel has been identified as a key regulator of ApoBD formation, influencing both nuclear content packaging and ApoBD size. Pharmacologically targeting PANX1 activity may enhance the therapeutic potential of ApoBD-based therapies.

PROTEOMICS (2021)

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Article Multidisciplinary Sciences

Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands

Allison Kupsco et al.

Summary: Human milk extracellular vesicles (EVs) containing microRNAs (miRNAs) play a critical role in infant cognitive, immune, and cardiometabolic functions. The expression of many top-cluster human milk EV-miRNAs is highly correlated, and they are involved in pathways related to the endocrine system, cellular community, neurodevelopment, and cancers. Further studies are needed to elucidate the determinants of human milk EV-miRNAs and their impact on health outcomes.

SCIENTIFIC REPORTS (2021)

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Review Cell Biology

Why Cells and Viruses Cannot Survive without an ESCRT

Arianna Calistri et al.

Summary: The complex network of intracellular organelles and vesicles trafficking plays a central role in eukaryotic cells, with ESCRT machinery exerting multiple functions in membrane remodeling, cellular processes control, and viral infection.

CELLS (2021)

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Article Nutrition & Dietetics

Exposure to 3′Sialyllactose-Poor Milk during Lactation Impairs Cognitive Capabilities in Adulthood

Edoardo Pisa et al.

Summary: Research has shown that early exposure to breast milk lacking 3′SL can lead to decreased attention, spatial and working memory, as well as altered long-term potentiation in the hippocampal region in adulthood.

NUTRIENTS (2021)

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Review Nutrition & Dietetics

Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review

Francesca Lockyer et al.

Summary: Micronutrients are crucial for healthy brain development in infants, and deficiencies in breast milk may impact cognitive outcomes. Current research on the relationship between breast milk micronutrients and infant developmental outcomes is limited, highlighting the need for further investigation in this area.

NUTRIENTS (2021)

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Article Cell Biology

Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses

Marijke Zonneveld et al.

Summary: Maternal milk extracellular vesicles play a crucial role in supporting epithelial barrier function and modulating the immune system. Their unique proteome can target key hotspots of signaling networks in various cell types within the gastrointestinal tract.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Multidisciplinary Sciences

Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma

Elena Y. Komarova et al.

Summary: The release of Hsp70 chaperone from tumor cells can trigger a full-scale and effective anti-tumor immune response when specifically treated cancer cells generate Hsp70-containing EVs. This leads to enhanced NK cell toxicity towards melanoma, reduced tumor growth rate, and prolonged lifespan in animal models. Furthermore, pre-treating melanoma cells with Hsp70-enriched EVs can decrease the generation of tumor-associated macrophages, demonstrating the immunomodulatory effect of Hsp70-containing EVs.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Small RNAs are modified with N-glycans and displayed on the surface of living cells

Ryan A. Flynn et al.

Summary: This study challenges the conventional view that RNA is not a major target of glycosylation by providing evidence that mammals use RNA as a third scaffold for glycosylation. The researchers found that conserved small noncoding RNAs bear sialylated glycans, which are present in multiple cell types and mammalian species. The majority of glycoRNAs were located on the cell surface and were shown to interact with anti-dsRNA antibodies and members of the Siglec receptor family, suggesting a direct interface between RNA biology and glycobiology.

CELL (2021)

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Article Immunology

Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition

Antti E. Seppo et al.

Summary: The study found that maternal milk composition under the traditional Old Order Mennonite (OOM) farming lifestyle is beneficial in preventing allergic diseases in children, with higher levels of specific immune antibodies and other substances compared to residents in other regions. Additionally, there are significant differences in the composition of milk between OOM and ROC areas.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Allergy

Genetic variants in Hippo pathway genes are associated with house dust mite-induced allergic rhinitis in a Chinese population

Min Chen et al.

Summary: This study revealed that rs754466 in the DLG5 gene is significantly associated with a decreased risk of HDM-induced AR, with the A allele reducing the risk in the moderate/severe nasal symptom score subgroup. The rs754466 variant is also linked to higher mRNA expression of DLG5 and is situated in a region with enriched histone modification and transcription factor binding sites.

CLINICAL AND TRANSLATIONAL ALLERGY (2021)

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Review Cell Biology

A brief history of nearly EV-erything - The rise and rise of extracellular vesicles

Yvonne Couch et al.

Summary: Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space, serving as a complex cell-to-cell communication mechanism that transfers functional cargo and influences biological processes, with deregulation in disease. The field of EVs has grown exponentially over the past two decades with an organized community, but still faces key challenges.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Medicine, General & Internal

Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

Wararat Chiangjong et al.

Summary: Red blood cell-derived extracellular vesicles (RBCEVs) have shown potential for clinical applications due to their safety and biocompatibility, allowing for precise treatment by encapsulating genetic materials and releasing them into target cells. Challenges remain in terms of side effects, half-lives, target cell specificity, and large-scale production under good manufacturing practice.

FRONTIERS IN MEDICINE (2021)

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Article Food Science & Technology

Lipidomic Profiling of Human Milk Derived Exosomes and Their Emerging Roles in the Prevention of Necrotizing Enterocolitis

Wenjuan Chen et al.

Summary: The study reveals the complexity of lipid expression profiles in exosomes derived from preterm and term human milk. The top 50 lipids identified in the exosomes regulate intestinal epithelial cell function via the ERK/MAPK pathway, providing novel mechanistic insight on how human milk prevents the development of necrotizing enterocolitis (NEC).

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Neurosciences

Aberrant expression of miR-148a-3p in Alzheimer's disease and its protective role against amyloid-β induced neurotoxicity

Hao Zhang et al.

Summary: In this study, the expression of miR-148a-3p was found to be downregulated in AD patients, positively correlated with MMSE score, and potentially useful for AD diagnosis. Overexpression of miR-148a-3p attenuated Aβ-induced neurotoxicity in AD by targeting ROCK1.

NEUROSCIENCE LETTERS (2021)

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Review Pediatrics

Human Milk, More Than Simple Nourishment

Giulia Vizzari et al.

Summary: Human breast milk contains various bioactive factors that play important roles in infant neuro-cognitive development, immune modulation, and microbiome development. Despite significant advancements in understanding breast milk potential, the exact mechanisms of its bioactivity remain unclear.

CHILDREN-BASEL (2021)

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Article Cell Biology

miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome

Xiaodong Xu et al.

Summary: Aberrant expression of miR-30d in pancreatic cancer is associated with poor prognosis and early relapse of patients. The tumor suppressive effect of miR-30d is mediated through direct targeting of SOX4, leading to inhibition of the PI3K-AKT signaling pathway and repression of pancreatic cancer cell growth and metastasis.

CELL DEATH & DISEASE (2021)

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Article Nutrition & Dietetics

Human Milk Exosomal MicroRNA: Associations with Maternal Overweight/Obesity and Infant Body Composition at 1 Month of Life

Kruti B. Shah et al.

Summary: Breast milk is a rich source of microRNAs, specifically miRNAs. This study aimed to investigate the impact of maternal overweight/obesity on select miRNAs related to adipogenesis and glucose metabolism, and their relationship with infant body composition. The findings showed that miR-148a and miR-30b were significantly lower in overweight/obese mothers compared to normal-weight mothers at 1 month, with associations between these miRNAs and infant weight and body composition.

NUTRIENTS (2021)

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Review Immunology

Emerging Role of Exosomes in Tuberculosis: From Immunity Regulations to Vaccine and Immunotherapy

Yin-Fu Sun et al.

Summary: Exosomes are important signal transport vectors for cell-cell communication and immune modulation, playing a critical role in anti-MTB immune response. Infected-cell-derived exosomes trigger different immune responses during tuberculosis infection, highlighting their potential in developing new vaccination and treatment strategies for TB. Exosomes, as a novel kind of delivery system, show promise in the field of novel anti-MTB vaccines and therapies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Nutrition & Dietetics

Human milk 3′-Sialyllactose is positively associated with language development during infancy

Seoyoon Cho et al.

Summary: This study found a positive association between 3'-SL and cognition, particularly language functions, in typically developing children who received human milk containing detectable A-tetra during infancy.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

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Review Biochemical Research Methods

A complete proteomic profile of human and bovine milk exosomes by liquid chromatography mass spectrometry

Kanchan Manohar Vaswani et al.

Summary: The study investigated the proteomic content of milk exosomes from humans and cows, identifying similarities and differences in protein content. A total of 176 and 186 unique proteins were found in human and bovine milk exosomes, respectively, with 53 proteins common to both species.

EXPERT REVIEW OF PROTEOMICS (2021)

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Article Multidisciplinary Sciences

NORAD-induced Pumilio phase separation is required for genome stability

Mahmoud M. Elguindy et al.

Summary: Liquid-liquid phase separation is a key mechanism through which long noncoding RNA controls RNA-binding proteins and maintains genomic stability in mammalian cells. The study shows that RNA-driven phase separation competitively sequesters RNA-binding proteins by nucleating the formation of phase-separated condensates, influencing RBP activity and genome maintenance. The repetitive sequence architecture of lncRNAs suggests that phase separation may be a widely used mechanism of lncRNA-mediated regulation.

NATURE (2021)

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Editorial Material Cell Biology

RNA, a new member in the glycan-club that gets exposed at the cell surface

Eric Chevet et al.

TRAFFIC (2021)

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Article Oncology

MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1

Qing Chen et al.

Summary: The study revealed that miR-148a-3p expression levels were significantly decreased in cervical cancer, and it inhibited the proliferation of cervical cancer cells by regulating the expression levels of DNMT1/UTF1.

ONCOLOGY LETTERS (2021)

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Article Nutrition & Dietetics

Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection

Yingying He et al.

Summary: Exosomes in human body fluids contain immune-modulatory components like human milk oligosaccharides, which play critical roles in infant immune system development. These exosomes can be uptaken by macrophages and protect against infections and inflammation, showing promise in providing a natural way for immune regulation in newborns. Understanding the interaction between a mother's breastfeeding and infant mucosal immune system development is advantageous for utilizing exosome-like particles to transport milk oligosaccharides to their targets.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation

Sho Okumura et al.

Summary: The study reveals that microRNA-148a plays a crucial role in breast cancer cell proliferation, with knockdown of miR-148a leading to a greater and longer-lasting inhibition of cell growth compared to targeting oncogenic microRNA-21. Additionally, the study identifies thioredoxin-interacting protein (TXNIP) as a target gene of miR-148a, showing that sequestering miR-148a can provoke an increase in TXNIP mRNA expression.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Exosomal delivery of therapeutic modulators through the blood-brain barrier; promise and pitfalls

Morteza Heidarzadeh et al.

Summary: Current drug delivery strategies for neurological disorders face challenges due to the blood-brain barrier (BBB) limiting transport to the brain parenchyma. Stem cell byproducts such as exosomes are proposed as natural nano-drug carriers, but the intact BBB may hinder their delivery. Understanding the molecular mechanisms behind exosomal trafficking through the BBB remains unclear despite some preliminary studies showing potential.

CELL AND BIOSCIENCE (2021)

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Review Immunology

Non-Coding RNAs in Human Breast Milk: A Systematic Review

Lina Tingo et al.

Summary: Breast milk contains a variety of RNA types, including miRNAs, with some miRNAs being widely reported across different fractions. It is currently challenging to determine which factors influence the characteristics of the miRNA profile, but studies suggest that certain miRNAs are highly expressed and stable in breast milk. Future research needs to further explore the biological effects of miRNAs in breast milk and characterize other ncRNAs.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles

Oskar Staufer et al.

Summary: Extracellular vesicles play a crucial role in intercellular communication and cell physiology, but quantitative knowledge on their signaling mechanisms is lacking, hampering their therapeutic applications. By using a synthetic approach, researchers have shown that synthetic EVs have functionalities similar to natural EVs and can be used for therapeutic purposes in wound healing and neovascularization. Transcriptome profiling has enabled a systematic decoding of synergistic effects between individual EV constituents, leading to a better understanding of EV signaling.

SCIENCE ADVANCES (2021)

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Review Cell Biology

Siglec Ligands

Anabel Gonzalez-Gil et al.

Summary: Glycans on the cell surface play important roles in cell physiology, with Siglecs being a type of glycan binding protein that regulates cellular responses by interacting with sialylated glycans. The study of Siglec ligands, including both natural and synthetic compounds, presents new opportunities for understanding molecular pathways controlling cell physiology and for therapeutic interventions.

CELLS (2021)

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Article Biochemistry & Molecular Biology

HMP-S7 Is a Novel Anti-Leukemic Peptide Discovered from Human Milk

Wararat Chiangjong et al.

Summary: HMP-S7, a novel anti-leukemic peptide with 3+ charges and an alpha helical structure, exhibits selective cytotoxic activity against leukemic cells while sparing solid malignancies and normal cells. It induces leukemic cell death by penetrating the plasma membrane to enter the cytoplasm and cause the leakage of lactate dehydrogenase. Further validation in preclinical and clinical studies is needed to confirm its anti-leukemic effects.

BIOMEDICINES (2021)

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Review Biochemistry & Molecular Biology

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

David L. Bernstein et al.

Summary: The let-7 family of microRNAs is highly expressed in the cerebral and cardiovascular systems, and plays a role in cardiovascular diseases and associated inflammation. It is involved in the development and differentiation of embryonic stem cells in the cardiovascular system, and may serve as a research focus for potential therapeutic targets in cardiovascular diseases.

BIOMEDICINES (2021)

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Review Biotechnology & Applied Microbiology

Advances in the analysis of single extracellular vesicles: A critical review

Shannon H. Hilton et al.

Summary: There is a growing need for new cancer diagnostic approaches, with extracellular vesicles (EVs) showing potential to provide earlier and more complete diagnostic information. Current methods for analyzing EVs are limited, but new approaches for single EV analysis are emerging, offering opportunities for studying biogenesis.

SENSORS AND ACTUATORS REPORTS (2021)

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Article Oncology

Targeted Oral Delivery of Paclitaxel Using Colostrum-Derived Exosomes

Raghuram Kandimalla et al.

Summary: Paclitaxel (PAC) is widely used in the treatment of various cancers, including lung cancer, but its solvent-based formulation is associated with severe side effects. Utilizing bovine colostrum-derived exosomes as a delivery system for PAC can enhance therapeutic efficacy and reduce toxicity, providing a promising alternative to current therapies. Studies show that a tumor-targeted oral formulation of PAC delivered by exosomes significantly improves efficacy and safety compared to traditional intravenous administration.

CANCERS (2021)

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Developmental Biology

Febrile Seizure-Related miR-148a-3p Exerts Neuroprotection by Promoting the Proliferation of Hippocampal Neurons in Children with Temporal Lobe Epilepsy

Yanhui Yu et al.

Summary: The study identified that miR-148a-3p is overexpressed in children with TLE and associated with seizure frequency and history of febrile seizures, demonstrating its value as a diagnostic biomarker for TLE. Downregulation of miR-148a-3p improves hippocampal neuronal cell viability, suggesting a neuroprotective role. This miRNA may offer new insights for the treatment and diagnosis of TLE.

DEVELOPMENTAL NEUROSCIENCE (2021)

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Article Health Care Sciences & Services

Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study

Ardythe L. Morrow et al.

Summary: The PREVAIL Cohort study aims to document the natural history of enteric and respiratory infections and immunity in children aged 0-2 years in the United States. Out of 245 mother-child pairs enrolled, 194 were compliant with the study requirements.

JMIR RESEARCH PROTOCOLS (2021)

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Review Cell Biology

The many functions of ESCRTs

Marina Vietri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Pediatrics

Human breast milk exosomes attenuate intestinal damage

Hiromu Miyake et al.

PEDIATRIC SURGERY INTERNATIONAL (2020)

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Article Toxicology

Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice

Akiko Matsuda et al.

JOURNAL OF APPLIED TOXICOLOGY (2020)

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Review Cell & Tissue Engineering

Extracellular vesicles and their roles in stem cell biology

Yun H. Hur et al.

STEM CELLS (2020)

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Review Nutrition & Dietetics

The Impact of Maternal Obesity on Human Milk Macronutrient Composition: A Systematic Review and Meta-Analysis

Gabriela E. Leghi et al.

NUTRIENTS (2020)

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Review Cell Biology

Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases

Michael Groot et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Exposure of Intestinal Epithelial Cells to 2′-Fucosyllactose and CpG Enhances Galectin Release and Instructs Dendritic Cells to Drive Th1 and Regulatory-Type Immune Development

Veronica Ayechu-Muruzabal et al.

BIOMOLECULES (2020)

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Article Endocrinology & Metabolism

MicroRNA-148a-3p alleviates high glucose-induced diabetic retinopathy by targeting TGFB2 and FGF2

Jihong Wang et al.

ACTA DIABETOLOGICA (2020)

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Article Neurosciences

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

Stephen A. Fleming et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Medical Laboratory Technology

MicroRNA-148a-3p inhibits cancer progression and is a novel screening biomarker for gastric cancer

Chenhui Bao et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

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Article Microbiology

Extracellular Vesicles in Human Preterm Colostrum Inhibit Infection by Human Cytomegalovirus In Vitro

Manuela Donalisio et al.

MICROORGANISMS (2020)

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Review Cardiac & Cardiovascular Systems

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease JACC State-of-the-Art Review

Vivek Narayan et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Unleashing the therapeutic potential of apoptotic bodies

Thanh Kha Phan et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

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Article Multidisciplinary Sciences

Impact of processing method on donated human breast milk microRNA content

Urszula Smyczynska et al.

PLOS ONE (2020)

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Article Developmental Biology

Milk exosomes and miRNA cross the placenta and promote embryo survival in mice

Mahrou Sadri et al.

REPRODUCTION (2020)

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Article Nutrition & Dietetics

Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression

Stephen A. Fleming et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo

Hongyu Tao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Sergey Sedykh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction

Jana Jankovicova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

MicroRNA-148a-3p suppresses epithelial-to-mesenchymal transition and stemness properties via Wnt1-mediated Wnt/β-catenin pathway in pancreatic cancer

Xiaowei Fu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Nutrition & Dietetics

Cow and Human Milk-Derived Exosomes Ameliorate Colitis in DSS Murine Model

Shimon Reif et al.

NUTRIENTS (2020)

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Article Infectious Diseases

Anti-Zika virus and anti-Usutu virus activity of human milk and its components

Rachele Francese et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

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Article Cell Biology

The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma

Julia Paczkowska et al.

CELLS (2020)

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Article Medicine, Research & Experimental

Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858

Cheng Liu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Hematology

Human milk triggers coagulation via tissue factor-exposing extracellular vesicles

Yong Hu et al.

BLOOD ADVANCES (2020)

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Review Oncology

The evolving translational potential of small extracellular vesicles in cancer

Andreas Moller et al.

NATURE REVIEWS CANCER (2020)

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Article Medicine, General & Internal

Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation

Yao Wu et al.

JAMA NETWORK OPEN (2020)

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Article Cell & Tissue Engineering

Protective Effects of Human Milk-Derived Exosomes on Intestinal Stem Cells Damaged by Oxidative Stress

Ping Dong et al.

CELL TRANSPLANTATION (2020)

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Review Biochemistry & Molecular Biology

Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

Tore Skotland et al.

JOURNAL OF LIPID RESEARCH (2019)

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Review Clinical Neurology

Exosomes-beyond stem cells for restorative therapy in stroke and neurological injury

Zheng Gang Zhang et al.

NATURE REVIEWS NEUROLOGY (2019)

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Review Pediatrics

Fortification of Human Milk for Preterm Infants: Update and Recommendations of the European Milk Bank Association (EMBA) Working Group on Human Milk Fortification

Sertac Arslanoglu et al.

FRONTIERS IN PEDIATRICS (2019)

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Article Obstetrics & Gynecology

Breastfeeding: Investing in the Future

Bernardo L. Horta

BREASTFEEDING MEDICINE (2019)

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Article Oncology

Milk exosomes - Natural nanoparticles for siRNA delivery

Farrukh Aqil et al.

CANCER LETTERS (2019)

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Review Immunology

Transforming Growth Factor-β Signaling in Immunity and Cancer

Eduard Batlle et al.

IMMUNITY (2019)

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Article Food Science & Technology

Identification and Peptidomic Profiling of Exosomes in Preterm Human Milk: Insights Into Necrotizing Enterocolitis Prevention

Xingyun Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

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Article Multidisciplinary Sciences

Long-term studies will track indelible marks of first flu

Declan Butler

NATURE (2019)

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Review Immunology

The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation

Poshmaal Dhar et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Article Pediatrics

Association of Perceived Maternal Stress During the Perinatal Period With Electroencephalography Patterns in 2-Month-Old Infants

Lara J. Pierce et al.

JAMA PEDIATRICS (2019)

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Editorial Material Cell Biology

Extracellular vesicles: a new communication paradigm?

Graca Raposo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Cell Biology

The Hsp70 chaperone network

Rina Rosenzweig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Medicine, General & Internal

Three contaminated sites in southern Italy. The Neonatal Environment and Health Outcomes cohort: protocol for a longitudinal birth cohort study

Silvia Ruggieri et al.

BMJ OPEN (2019)

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Article Pharmacology & Pharmacy

MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

Linlin Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Medicine, Research & Experimental

Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon tumor cells in a miRNA-dependent manner

Shimon Reif et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Article Pediatrics

A comparison of exosomes derived from different periods breast milk on protecting against intestinal organoid injury

Runnan Gao et al.

PEDIATRIC SURGERY INTERNATIONAL (2019)

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Article Nutrition & Dietetics

Breast Milk Supply of MicroRNA Associated with Leptin and Adiponectin Is Affected by Maternal Overweight/Obesity and Influences Infancy BMI

Rocio Zamanillo et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

miR-22-3p is involved in gluconeogenic pathway modulated by 3,5-diiodo-L-thyronine (T2)

Rosalba Senese et al.

SCIENTIFIC REPORTS (2019)

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Article Immunology

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs

Aashiq H. Mirza et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Allergy

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood

Mikail Berdi et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2019)

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Article Agriculture, Dairy & Animal Science

Milk-Derived Exosomes and Metabolic Regulation

Janos Zempleni et al.

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 7 (2019)

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Review Cell Biology

Toward characterizing extracellular vesicles at a single-particle level

Chun-yi Chiang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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Article Biochemistry & Molecular Biology

MicroRNA 148a-3p promotes Thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting Kruppel-like factor 6

Heng'an Ge et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Obstetrics & Gynecology

Evaluation of Fetal Intestinal Cell Growth and Antimicrobial Biofunctionalities of Donor Human Milk After Preparative Processes

Pasinee Kanaprach et al.

BREASTFEEDING MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Exosomes and Ectosomes in Intercellular Communication

Jacopo Meldolesi

CURRENT BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Exosome enrichment by ultracentrifugation and size exclusion chromatography

Yong Qin Koh et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2018)

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Article Biochemistry & Molecular Biology

Human breast milk-derived exosomes attenuate cell death in intestinal epithelial cells

Colin Martin et al.

INNATE IMMUNITY (2018)

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Article Medicine, General & Internal

MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells

Kang-tai Lv et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Extracellular vesicles: lipids as key components of their biogenesis and functions

Michel Record et al.

JOURNAL OF LIPID RESEARCH (2018)

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Article Food Science & Technology

Exosomal MicroRNAs in Milk from Mothers Delivering Preterm Infants Survive in Vitro Digestion and Are Taken Up by Human Intestinal Cells

Sarah Kahn et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Review Immunology

Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer

Furong Zeng et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

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Review Endocrinology & Metabolism

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

Amin Ardestani et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

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Article Cell Biology

MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7

Yuan-Yuan Ye et al.

CELL DEATH & DISEASE (2018)

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Review Cell & Tissue Engineering

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

Somayeh Keshtkar et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Multidisciplinary Sciences

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Sonia Manca et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Multiplex Biomarker Screening Assay for Urinary Extracellular Vesicles Study: A Targeted LabelFree Proteomic Approach

Somchai Chutipongtanate et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

Johannes Schoneberg et al.

SCIENCE (2018)

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Article Nutrition & Dietetics

Sialic Acid and Sialylated Oligosaccharide Supplementation during Lactation Improves Learning and Memory in Rats

Elena Oliveros et al.

NUTRIENTS (2018)

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Article Medicine, General & Internal

Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden

Malin Barman et al.

BMJ OPEN (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales

Anna-Kristin Ludwig et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma

Priyanka Sharma et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Hematology

Ablation of miR-146b in mice causes hematopoietic malignancy

Takahiro Mitsumura et al.

BLOOD ADVANCES (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles

Paola de Candia et al.

FEBS LETTERS (2017)

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Article Food Science & Technology

Comparative proteomic analysis of milk-derived exosomes in human and bovine colostrum and mature milk samples by iTRAQ-coupled LC-MS/MS

Mei Yang et al.

FOOD RESEARCH INTERNATIONAL (2017)

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Article Agriculture, Multidisciplinary

Small Interfering RNA in Milk Exosomes Is Resistant to Digestion and Crosses the Intestinal Barrier In Vitro

Shruti Shandilya et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Editorial Material Urology & Nephrology

Breaking the ice: urine proteomics of medullary sponge kidney disease

Somchai Chutipongtanate

KIDNEY INTERNATIONAL (2017)

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Article Food Science & Technology

Characterization and biological function of milk-derived miRNAs

Regina Golan-Gerstl et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

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Article Food Science & Technology

Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells

Yalin Liao et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

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Article Nanoscience & Nanotechnology

Milk-derived exosomes for oral delivery of paclitaxel

Ashish K. Agrawal et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Review Biochemical Research Methods

Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications

Somchai Chutipongtanate et al.

PROTEOMICS CLINICAL APPLICATIONS (2017)

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Article Allergy

Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy

Lili E. Fodor et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

Farrukh Aqil et al.

FOOD & FUNCTION (2017)

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Article Nutrition & Dietetics

Dietary Sialyllactose Influences Sialic Acid Concentrations in the Prefrontal Cortex and Magnetic Resonance Imaging Measures in Corpus Callosum of Young Pigs

Austin T. Mudd et al.

NUTRIENTS (2017)

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Article Oncology

Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers

Scott Langevin et al.

ONCOTARGET (2017)

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Article Cell & Tissue Engineering

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

Carolina Balbi et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Pharmacology & Pharmacy

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin

Farrukh Aqil et al.

AAPS JOURNAL (2017)

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Article Biochemistry & Molecular Biology

Curcumin Encapsulated in Milk Exosomes Resists Human Digestion and Possesses Enhanced Intestinal Permeability in Vitro

Monika Vashisht et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2017)

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Article Cell Biology

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane

Kerstin Menck et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Pediatrics

Associations between human breast milk hormones and adipocytokines and infant growth and body composition in the first 6months of life

D. A. Fields et al.

PEDIATRIC OBESITY (2017)

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Article Endocrinology & Metabolism

Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts

Nicolai A. Lund-Blix et al.

DIABETES CARE (2017)

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Article Oncology

Exosomal formulation of anthocyanidins against multiple cancer types

Radha Munagala et al.

CANCER LETTERS (2017)

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Article Cell Biology

Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis

Rio Jati Kusuma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Characterisation of plasmalemmal shedding of vesicles induced by the cholesterol/sphingomyelin binding protein, ostreolysin A-mCherry

Matej Skocaj et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

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Article Biochemistry & Molecular Biology

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Sungyul Lee et al.

CELL (2016)

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Article Pathology

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

Farrukh Aqil et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2016)

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Article Allergy

Prenatal and postnatal stress and asthma in children: Temporal- and sex-specific associations

Alison Lee et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles

Katherine R. Martin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Nutrition & Dietetics

Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2′-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial

Karen C. Goehring et al.

JOURNAL OF NUTRITION (2016)

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Article Nutrition & Dietetics

The Human Milk Oligosaccharide 2′-Fucosyllactose Quenches Campylobacter jejuni-Induced Inflammation in Human Epithelial Cells HEp-2 and HT-29 and in Mouse Intestinal Mucosa

Zhuo-Teng Yu et al.

JOURNAL OF NUTRITION (2016)

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Article Biochemical Research Methods

Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components

Martijn J. C. van Herwijnen et al.

MOLECULAR & CELLULAR PROTEOMICS (2016)

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Article Cell Biology

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer

Xiao Wang et al.

CELL DEATH & DISEASE (2016)

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Article Multidisciplinary Sciences

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Nadia C. Correia et al.

SCIENTIFIC REPORTS (2016)

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Article Neurosciences

The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress

Qi Wu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

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Article Biotechnology & Applied Microbiology

Xanthine dehydrogenase: An old enzyme with new knowledge and prospects

Cheng-Hua Wang et al.

BIOENGINEERED (2016)

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Article Gastroenterology & Hepatology

The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation

YingYing He et al.

GUT (2016)

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Article Multidisciplinary Sciences

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro

Jennifer K. Lang et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk

Mohammed Alsaweed et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Human Milk Cells Contain Numerous miRNAs that May Change with Milk Removal and Regulate Multiple Physiological Processes

Mohammed Alsaweed et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Biochemistry & Molecular Biology

Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice

Adolf Geiger et al.

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