4.6 Article

Does MIS Play a Role in the Treatment of Advanced Ovarian Cancer?

期刊

CANCERS
卷 14, 期 15, 页码 -

出版社

MDPI
DOI: 10.3390/cancers14153579

关键词

interval cytoreduction; neoadjuvant chemotherapy; ovarian malignancy; primary cytoreduction; survival; progression-free survival

类别

向作者/读者索取更多资源

Minimally invasive surgery can be used for interval debulking after neoadjuvant chemotherapy in selected patients with initially unresectable ovarian cancer. It has the main benefits of shorter hospital stay and fewer intestinal resections compared to primary debulking. Neoadjuvant chemotherapy allows a minimally invasive approach for interval debulking in patients with ovarian cancer considered unresectable at diagnosis.
Simple Summary Minimally invasive surgery can be used for interval debulking after neoadjuvant chemotherapy in selected patients with ovarian cancer initial disease unresectable by laparotomy without compromising survival. The main benefit of minimally invasive surgery for primary and interval debulking is a shorter hospital stay. There are fewer intestinal resections at interval debulking compared with primary debulking. Neoadjuvant chemotherapy allows a minimally invasive approach for interval debulking in patients with ovarian cancer considered unresectable to no residual disease by laparotomy at diagnosis. The aim of the study was to evaluate the type of surgical approach at interval debulking (ID) after three courses of carboplatin and taxol in patients with unresectable ovarian cancer at diagnosis compared with the type of surgical approach at primary debulking (PD). A secondary objective was to compare the perioperative outcomes of MIS vs. laparotomy at ID. A retrospective review of the type of surgical approach at ID following three courses of carboplatin and taxol was compared with the surgical approach at PD, and a review of the perioperative outcomes of MIS vs. open at ID was performed during the period from 21 January 2012, through 21 February 2013, for stage IIIC > 2 cm or IV epithelial ovarian cancer (EOC) unresectable at diagnosis and the surgical approach at PD. During the study period, 127 patients with stage IIIC or IV EOC met the inclusion criteria. Minimally invasive surgery (MIS), laparoscopic or robotic, was used in 21.6% of patients at ID and in 23.3% of patients at PD. At ID, MIS patients had a shorter hospital stay as compared to laparotomy (2 vs. 8 days; p < 0.001). At 5 year follow-up, 31.5% of EOC patients were alive (ID MIS: 47.5% vs. ID open: 30%; PD MIS: 41% vs. PD open: 28%), while 24.4% had no evidence of disease (ID MIS: 39% vs. ID open: 19.5%; PD MIS: 32% vs. PD open: 22%). Among living patients, 22% had evidence of disease. Neoadjuvant chemotherapy is a form of chemo-debulking and allows a minimally invasive approach at interval debulking in about one-fifth of the patients, with initial disease deemed unresectable to no residual tumor at initial diagnosis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据