4.6 Review

Proteases and HPV-Induced Carcinogenesis

期刊

CANCERS
卷 14, 期 13, 页码 -

出版社

MDPI
DOI: 10.3390/cancers14133038

关键词

HPV; carcinogenesis; proteases; cervical cancer; anogenital cancer; oropharyngeal cancer

类别

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation
  2. FAPESP) [2014/06316-2, 2019/04896-5, 2018/16989-5]
  3. Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (FAEPA)
  4. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [310154/2021-9]
  5. CAPES (Brazilian Ministry of Education)
  6. CAPES

向作者/读者索取更多资源

Human papillomavirus (HPV) infection is a common sexually transmitted disease worldwide. While most infections do not lead to cancer, some HPV types are linked to cervical, anogenital, and oropharyngeal cancers. The role of proteases in HPV-induced carcinogenesis is emphasized in this review, along with recent epidemiological data.
Simple Summary Human papillomavirus (HPV) infection is a sexually transmitted disease with high prevalence worldwide. Although most HPV infections do not lead to cancer, some HPV types are correlated with the majority of cervical cancers, and with some anogenital and oropharyngeal cancers. Moreover, enzymes known as proteases play an essential role in the pathogenic process in HPV-induced carcinogenesis. This review highlights the role of proteases and recent epidemiological data regarding HPV-dependent carcinogenesis. Persistent infection with Human papillomavirus (HPV) is the main etiologic factor for pre-malignant and malignant cervical lesions. Moreover, HPV is also associated with oropharynx and other anogenital carcinomas. Cancer-causing HPV viruses classified as group 1 carcinogens include 12 HPV types, with HPV 16 and 18 being the most prevalent. High-risk HPVs express two oncoproteins, E6 and E7, the products of which are responsible for the inhibition of p53 and pRB proteins, respectively, in human keratinocytes and cellular immortalization. p53 and pRB are pleiotropic proteins that regulate the activity of several signaling pathways and gene expression. Among the important factors that are augmented in HPV-mediated carcinogenesis, proteases not only control processes involved in cellular carcinogenesis but also control the microenvironment. For instance, genetic polymorphisms of matrix metalloproteinase 1 (MMP-1) are associated with carcinoma invasiveness. Similarly, the serine protease inhibitors hepatocyte growth factor activator inhibitor-1 (HAI-1) and -2 (HAI-2) have been identified as prognostic markers for HPV-dependent cervical carcinomas. This review highlights the most crucial mechanisms involved in HPV-dependent carcinogenesis, and includes a section on the proteolytic cascades that are important for the progression of this disease and their impact on patient health, treatment, and survival.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据