Recent Advances in the Diagnosis and Management of High-Risk Cutaneous Squamous Cell Carcinoma

Review Dermatology

Adjuvant radiotherapy may not significantly change outcomes in high-risk cutaneous squamous cell carcinomas with clear surgical margins: A systematic review and meta-analysis

Yesul Kim et al.

Summary: There is no significant difference in poor outcomes between surgery alone and surgery with adjuvant radiotherapy for high-risk cutaneous squamous cell carcinoma patients.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Cumulative incidence and disease-specific survival of metastatic cutaneous squamous cell carcinoma: A nationwide cancer registry study

Selin Tokez et al.

Summary: This study investigated the cumulative incidence and disease-specific survival of patients with metastatic cutaneous squamous cell carcinoma (mcSCC) in the Dutch population and assessed patient-based risk factors. The results showed that approximately 2% of cSCCs metastasize, with higher risk for men, increasing age, and immunocompromised patients. The 5-year disease-specific survival for patients with mcSCC was high.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Review Dermatology

Epidemiology of advanced cutaneous squamous cell carcinoma

C. Dessinioti et al.

Summary: The lack of epidemiological data on locally advanced cSCC highlights the need for standardization in defining and reporting both locally advanced and metastatic cSCC. Metastatic cSCCs, though a small portion, have aggressive characteristics contributing to higher morbidity and mortality, requiring systemic treatments.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Review Dermatology

Overview of guideline recommendations for the management of high-risk and advanced cutaneous squamous cell carcinoma

C. Dessinioti et al.

Summary: Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer, and various guidelines have been issued to guide its management. However, there are still discrepancies among these guidelines, highlighting the need for further research.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

Assessment of the Diagnostic Accuracy of Baseline Clinical Examination and Ultrasonographic Imaging for the Detection of Lymph Node Metastasis in Patients With High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck

Selin Tokez et al.

Summary: In this study, baseline ultrasonography was found to be more sensitive than clinical examination alone for detecting lymph node metastasis in patients with high-risk cutaneous SCC of the head and neck. Ultrasonography showed high sensitivity for detecting nodal metastases, especially in patients with negative baseline clinical examination results. However, the high rate of false-positive findings should be taken into consideration.

JAMA DERMATOLOGY (2022)

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Article Dermatology

A Sensitivity Meta-Analysis of Disease-Specific Death in Localized Cutaneous Squamous Cell Carcinoma

Clio Dessinioti et al.

Summary: Patients with immunosuppression are at significantly higher risk of death from cSCC in localized cSCC at initial diagnosis. However, caution is needed in interpreting the results due to limited evidence-based data on DSD in localized cSCC, variability of selected risk factors, and variability in defining risk factors.

DERMATOLOGY (2022)

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Article Oncology

Enhanced metastatic risk assessment in cutaneous squamous cell carcinoma with the 40-gene expression profile test

Sherrif F. Ibrahim et al.

Summary: This study validates the prognostic value of the 40-GEP test for cutaneous squamous cell carcinoma patients and demonstrates that integrating the test with clinicopathologic risk factor assessment methods can improve risk classification, potentially informing risk-appropriate management strategies for patients.

FUTURE ONCOLOGY (2022)

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Article Dermatology

Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-center

Emily S. Ruiz et al.

Summary: This study evaluated the impact of adjuvant radiation therapy on high T-stage cutaneous squamous cell carcinomas following clear margin surgery. Results showed that adjuvant radiation therapy significantly reduced the risk of local recurrence and locoregional recurrence.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Risk factors for metastatic cutaneous squamous cell carcinoma: Refinement and replication based on 2 nationwide nested case-control studies

Selin Tokez et al.

Summary: This study analyzed and replicated the risk factors for metastatic cutaneous squamous cell carcinoma (cSCC) using two different datasets. In addition to diameter and thickness, poor differentiation, invasion, male sex, perineural/lymphovascular invasion, and facial localization were identified as significant risk factors for metastatic cSCC.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Outcome of cutaneous squamous cell carcinoma with microscopic residual disease after surgery and usefulness of postoperative radiotherapy: a retrospective cohort study

L. Revelles-Penas et al.

Summary: Microscopic residual disease (MRD) after surgery has an impact on the prognosis of cutaneous squamous cell carcinoma (CSCC), and postoperative radiotherapy (PORT) can improve local control in patients with MRD.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma

Ashley Wysong et al.

Summary: A gene expression profile (GEP) test was developed and validated to predict metastasis risk in high-risk cutaneous squamous cell carcinoma (cSCC) patients, improving risk-directed patient management.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Letter Dermatology

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in psoriasis and atopic dermatitis: A case-control study

Alberto Conde-Ferreiros et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020

S. G. Keohane et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

A Systematic Review of Primary, Adjuvant, and Salvage Radiation Therapy for Cutaneous Squamous Cell Carcinoma

Aimee E. Krausz et al.

Summary: The study reviewed 46 studies on the efficacy of primary and adjuvant/salvage RT for the treatment of cSCC, showing promising results overall, but with higher rates of local recurrence for T3 and T4 tumors. Prospective randomized studies comparing outcomes by tumor stage are needed to guide treatment guidelines.

DERMATOLOGIC SURGERY (2021)

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Review Dermatology

Efficacy and prognostic factors of adjuvant radiotherapy for cutaneous squamous cell carcinoma: A systematic review and meta-analysis

J. Zhang et al.

Summary: This systematic review and meta-analysis found that adjuvant radiotherapy for cutaneous squamous cell carcinoma can reduce recurrence risk, prolong disease-free survival, and improve overall survival. Additionally, postoperative radiotherapy significantly contributes to better overall survival in these patients.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Dermatology

Factors predicting outcomes of patients with high-risk squamous cell carcinoma treated with Mohs micrographic surgery

Andrew Matsumoto et al.

Summary: Research on the long-term outcomes of high-risk cutaneous squamous cell carcinomas (hrSCC) treated with Mohs micrographic surgery (MMS) is limited. MMS remains an effective treatment for hrSCC, with factors like perineural invasion, poor differentiation, and immunosuppression associated with poor outcomes. Further study is needed on the effect of adjuvant treatment.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Long-term clinical outcomes of patients with invasive cutaneous squamous cell carcinoma treated with Mohs micrographic surgery: A 5-year, multicenter, prospective cohort study

Amanda J. Tschetter et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Evaluation of the utility of localized adjuvant radiation for node-negative primary cutaneous squamous cell carcinoma with clear histologic margins

Emily Stamell Ruiz et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Detection of subclinical disease with baseline and surveillance imaging in high-risk cutaneous squamous cell carcinomas

Jacqueline M. Maher et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Postoperative radiotherapy provides better local control and long-term outcome in selective cases of cutaneous squamous cell carcinoma with perineural invasion

J. Canueto et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Article Oncology

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention

Alexander J. Stratigos et al.

EUROPEAN JOURNAL OF CANCER (2020)

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Article Oncology

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment

Alexander J. Stratigos et al.

EUROPEAN JOURNAL OF CANCER (2020)

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Article Otorhinolaryngology

Association of Immunosuppression With Outcomes of Patients With Cutaneous Squamous Cell Carcinoma of the Head and Neck

Samantha Tam et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2020)

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Article Dermatology

Performance of the American Joint Committee on Cancer Staging Manual, 8th Edition vs the Brigham and Women's Hospital Tumor Classification System for Cutaneous Squamous Cell Carcinoma

Emily Stamell Ruiz et al.

JAMA DERMATOLOGY (2019)

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Letter Dermatology

Surgery and Salvage Limited-Field Irradiation for Control of Cutaneous Squamous Cell Carcinoma With Microscopic Residual Disease

Emily Stamell Ruiz et al.

JAMA DERMATOLOGY (2019)

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Article Dermatology

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Zoe C. Venables et al.

JAMA DERMATOLOGY (2019)

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Article Oncology

Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial

Sandro Virgilio Porceddu et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Combination of post-operative radiotherapy and cetuximab for high-risk cutaneous squamous cell cancer of the head and neck: A propensity score analysis

Joshua D. Palmer et al.

ORAL ONCOLOGY (2018)

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Article Dermatology

Survival of Patients with Cutaneous Squamous Cell Carcinoma: Results of a Prospective Cohort Study

Thomas K. Eigentler et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Dermatology

The positive impact of radiologic imaging on high-stage cutaneous squamous cell carcinoma management

Emily Stamell Ruiz et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Article Medicine, General & Internal

Role of Concurrent Systemic Therapy with Adjuvant Radiation Therapy for Locally Advanced Cutaneous Head and Neck Squamous Cell Carcinoma

Uma Goyal et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2017)

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Review Dermatology

Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease

Kyle A. Burton et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2016)

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Article Dermatology

Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death A Systematic Review and Meta-analysis

Agnieszka K. Thompson et al.

JAMA DERMATOLOGY (2016)

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Article Surgery

The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival A Retrospective Follow-Up Study

Jacobus Nick Brinkman et al.

ANNALS OF PLASTIC SURGERY (2015)

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Article Dermatology

S1 guideline: microscopically controlled surgery (MCS)

Christoph R. Loeser et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2015)

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Review Dermatology

High-risk cutaneous squamous cell carcinoma and the emerging role of sentinel lymph node biopsy: A literature review

Cristian Navarrete-Dechent et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Oncology

Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital Tumor Staging for Cutaneous Squamous Cell Carcinoma

Pritesh S. Karia et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

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Review Otorhinolaryngology

Utility of Head and Neck Cutaneous Squamous Cell Carcinoma Sentinel Node Biopsy: A Systematic Review

Mostafa M. Ahmed et al.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2014)

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Article Dermatology

Staging for Cutaneous Squamous Cell Carcinoma as a Predictor of Sentinel Lymph Node Biopsy Results Meta-analysis of American Joint Committee on Cancer Criteria and a Proposed Alternative System

Adam R. Schmitt et al.

JAMA DERMATOLOGY (2014)

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Article Oncology

Phase 1 Study of Erlotinib Plus Radiation Therapy in Patients With Advanced Cutaneous Squamous Cell Carcinoma

C. Hope Heath et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)

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Article Medicine, General & Internal

Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies

Louise Lansbury et al.

BMJ-BRITISH MEDICAL JOURNAL (2013)

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Article Dermatology

Evaluation of AJCC Tumor Staging for Cutaneous Squamous Cell Carcinoma and a Proposed Alternative Tumor Staging System

Anokhi Jambusaria-Pahlajani et al.

JAMA DERMATOLOGY (2013)

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Article Dermatology

Factors Predictive of Recurrence and Death From Cutaneous Squamous Cell Carcinoma A 10-Year, Single-Institution Cohort Study

Chrysalyne D. Schmults et al.

JAMA DERMATOLOGY (2013)

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Review Oncology

Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature

Steve Kwon et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2011)

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Article Oncology

Cutaneous squamous cell carcinoma (SCC) of the head and neck: Risk factors of overall and recurrence-free survival

Athanassios Kyrgidis et al.

EUROPEAN JOURNAL OF CANCER (2010)

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Article Oncology

Analysis of risk factor's determining prognosis of cutaneous squamous-cell carcinoma:: a prospective study

Kay D. Brantsch et al.

LANCET ONCOLOGY (2008)

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Article Oncology

Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma

Abenaa M. Brewster et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

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Review Dermatology

A confusing world:: what to call histology of three-dimensional tumour margins?

M. Moehrle et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2007)

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Article Medicine, General & Internal

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

JA Bonner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Article Oncology

Mortality risk from squamous cell skin cancer

GL Clayman et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

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Article Surgery

Audit of clinical and histological prognostic factors in primary invasive squamous cell carcinoma of the skin: assessment in a minimum 5 year follow-up study after conventional excisional surgery

RW Griffiths et al.

BRITISH JOURNAL OF PLASTIC SURGERY (2002)

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Recent Advances in the Diagnosis and Management of High-Risk Cutaneous Squamous Cell Carcinoma

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