4.6 Article

Myeloid Derived Suppressor Cells Migrate in Response to Flow and Lymphatic Endothelial Cell Interaction in the Breast Tumor Microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression

Christopher Groth et al.

Summary: Myeloid-derived suppressor cells (MDSC) are a heterogeneous myeloid cell population expanded in tumor-bearing hosts and contribute to immunosuppression, making them a valuable therapeutic target. In melanoma, both polymorphonuclear (PMN) and monocytic (M) MDSC subsets have comparable immunosuppressive activities, with PMN-MDSC recruitment mediated by the CXCR2/CXCL1 axis. Inhibiting CXCR2 decreases PMN-MDSC infiltration, improves survival, and reduces metastasis, suggesting a critical role of PMN-MDSC in suppressing the NK cell-mediated anti-tumor response.

CANCERS (2021)

Article Cell Biology

Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response

Qods Lahmar et al.

Summary: Tumors evade the immune system by recruiting MDSCs to tdLNs and inhibiting T-cell activation before reaching the highly immunosuppressive tumor microenvironment.

CELLULAR IMMUNOLOGY (2021)

Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Oncology

Clinical relevance of systemic monocytic-MDSCs in patients with metastatic breast cancer

Caroline Bergenfelz et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

Review Cell Biology

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Andrew M. K. Law et al.

Article Multidisciplinary Sciences

Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas

Bassel Dawod et al.

SCIENTIFIC REPORTS (2020)

Article Oncology

How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions

Annika M. Bruger et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

Review Oncology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Tongyan Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

Myeloid-derived suppressor cells in hematological malignancies: friends or foes

Meng Lv et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

The hypoxic tumour microenvironment

Varvara Petrova et al.

ONCOGENESIS (2018)

Review Immunology

The Yin and Yang of Myeloid Derived Suppressor Cells

Snehil Budhwar et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Cell Biology

Lymphangiogenesis guidance by paracrine and pericellular factors

Kari Vaahtomeri et al.

GENES & DEVELOPMENT (2017)

Article Oncology

Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients

Kimberly R. Jordan et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Review Cell Biology

Lymphatic system: An active pathway for immune protection

Shan Liao et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Article Medical Laboratory Technology

Complexity and challenges in defining myeloid-derived suppressor cells

Vera Damuzzo et al.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2014)

Review Oncology

Interstitial fluid flow in cancer: implications for disease progression and treatment

Jennifer M. Munson et al.

CANCER MANAGEMENT AND RESEARCH (2014)

Editorial Material Oncology

MIF Metastasis/MDSC-inducing factor?

Kendra D. Simpson et al.

ONCOIMMUNOLOGY (2013)

Article Cell Biology

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

Ulrike Haessler et al.

INTEGRATIVE BIOLOGY (2012)

Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Interstitial flow influences direction of tumor cell migration through competing mechanisms

William J. Polacheck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

Suzanne Ostrand-Rosenberg

CANCER IMMUNOLOGY IMMUNOTHERAPY (2010)

Article Cardiac & Cardiovascular Systems

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

Dimana O. Miteva et al.

CIRCULATION RESEARCH (2010)

Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Immunology

Subsets of myeloid-derived suppressor cells in tumor-bearing mice

Je-In Youn et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model

CP Ng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)