4.6 Article

Widespread alterations in microRNA biogenesis in human Huntington's disease putamen

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

MicroRNA editing patterns in Huntington's disease

Shiyong Guo et al.

Summary: This study identified miRNA editing sites and SNPs in the brains of Huntington's disease (HD) patients, and found significantly different editing levels in the prefrontal cortex. Furthermore, the edited hsa-mir-10b was shown to downregulate GTPBP10, which may contribute to the progression of HD.

SCIENTIFIC REPORTS (2022)

Article Neurosciences

The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade

Richard A. Hickman et al.

Summary: Huntington disease is characterized by progressive neurodegeneration and the presence of polyglutamine huntingtin inclusions. This study found that the distribution and density of HTT inclusions in the cerebral cortex are regionally contingent and dependent on CAG repeat expansion, but are not related to the grade of striatal degeneration or the duration of clinical disease.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Transcriptional Dysregulation in Huntington's Disease: The Role in Pathogenesis and Potency for Pharmacological Targeting

Aleksandra Pogoda et al.

Summary: Huntington's disease is a genetic neurodegenerative disorder caused by a mutation in the Htt gene. Dysfunction of multiple transcription factors is implicated in the pathological changes associated with HD. Investigating the role of these transcription factors in the development of HD may lead to potential therapeutic interventions.

CURRENT MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology

Marie Rieux et al.

Summary: Huntington's disease is a monogenic neurodegenerative disorder caused by a mutation in the huntingtin gene, with evidence suggesting that the mutant huntingtin protein (mHTT) can spread through the bloodstream and induce pathology. Through a parabiosis approach, it was observed that mHTT can propagate and cause pathological changes in normal mice, while healthy blood can attenuate pathology. These findings have implications for the development of therapies for HD.

MOLECULAR PSYCHIATRY (2021)

Review Neurosciences

MicroRNAs in Huntington's Disease: Diagnostic Biomarkers or Therapeutic Agents?

Xiaoyu Dong et al.

Summary: miRNA is a key molecule in the growth and function of the nervous system. Dysregulated miRNA expression has been linked to neurodegenerative disorders like Huntington's disease, suggesting potential roles as biomarkers and therapeutic targets in these diseases.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Cell Biology

Altered microRNA expression in animal models of Huntington's disease and potential therapeutic strategies

Bridget Martinez et al.

Summary: Studies have shown that regulation of certain microRNAs in animal models and cell studies can improve symptoms of Huntington's disease, increase survival rates, and inhibit the production of mutant huntingtin protein.

NEURAL REGENERATION RESEARCH (2021)

Article Neurosciences

High-Throughput Sequencing of BACHD Mice Reveals Upregulation of Neuroprotective miRNAs at the Pre-Symptomatic Stage of Huntington's Disease

Isabella G. Olmo et al.

Summary: miRNAs altered in early stages of HD regulate genes related to cell survival, while their targets at 8 months of age are not significantly enriched in similar pathways, highlighting a potential neuroprotective role of miRNAs in the initial stages of the disease.

ASN NEURO (2021)

Review Biochemistry & Molecular Biology

MicroRNAs as major regulators of the autophagy pathway

Yunus Akkoc et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Editorial Material Biochemistry & Molecular Biology

On the Number of Functional microRNA Targets

Herve Seitz

MOLECULAR BIOLOGY AND EVOLUTION (2019)

Review Biochemistry & Molecular Biology

The Role of MicroRNAs in Spinocerebellar Ataxia Type 3

Sybille Krauss et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

Article Clinical Neurology

Platelet abnormalities in Huntington's disease

Helena L. Denis et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Multidisciplinary Sciences

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

Peter Langfelder et al.

PLOS ONE (2018)

Article Medicine, Research & Experimental

Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain

Masashi Fukuoka et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Review Neurosciences

Converging pathways in neurodegeneration, from genetics to mechanisms

Li Ga et al.

NATURE NEUROSCIENCE (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Clinical Neurology

Co-occurrence of mixed proteinopathies in late-stage Huntington's disease

Isabelle St-Amour et al.

ACTA NEUROPATHOLOGICA (2018)

Article Cell Biology

Dicer and microRNAs protect adult dopamine neurons

Piotr Chmielarz et al.

CELL DEATH & DISEASE (2017)

Review Neurosciences

RNAi mechanisms in Huntington's disease therapy: siRNA versus shRNA

Sebastian Aguiar et al.

TRANSLATIONAL NEURODEGENERATION (2017)

Article Behavioral Sciences

Memory formation and retention are affected in adult miR-132/212 knockout mice

Julia Hernandez-Rapp et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

Review Cell Biology

The biological functions of miRNAs: lessons from in vivo studies

Joana A. Vidigal et al.

TRENDS IN CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

The complexity of miRNA-mediated repression

A. Wilczynska et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

Yukio Kawahara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Neurosciences

Altered microRNA regulation in Huntington's disease models

Soon-Tae Lee et al.

EXPERIMENTAL NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy

Pascal Y. Smith et al.

HUMAN MOLECULAR GENETICS (2011)

Review Clinical Neurology

Huntington's disease: from molecular pathogenesis to clinical treatment

Christopher A. Ross et al.

LANCET NEUROLOGY (2011)

Article Multidisciplinary Sciences

The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation

Cathal McCann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Nuclear factor TDP-43 can affect selected microRNA levels

Emanuele Buratti et al.

FEBS JOURNAL (2010)

Article Biochemistry & Molecular Biology

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

Sebastien S. Hebert et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

A Role for Huntington Disease Protein in Dendritic RNA Granules

Jeffrey N. Savas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing

Eulalia Marti et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemistry & Molecular Biology

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

Tamara Ratovitski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

Trinna L. Cuellar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

Jeffrey N. Savas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Neurosciences

Role of brain-derived neurotrophic factor in Huntington's disease

Chiara Zuccato et al.

PROGRESS IN NEUROBIOLOGY (2007)

Review Clinical Neurology

The selective vulnerability of nerve cells in Huntington's disease

KA Sieradzan et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2001)