期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/jcm11154291
关键词
Alzheimer's disease; Amaryllidaceae alkaloids; Lycopodiaceae alkaloids; coumarins; acetylcholinesterase inhibitors; inflammation
资金
- Funds for Statutory Activity of Medical University of Lublin, Poland [36/2020/2021]
This study evaluated the safety and pharmacological activity of compounds obtained from various plant extracts, and found that these compounds have a high safety profile and significantly improve rodent memory.
The study aimed to evaluate the safety and pharmacological activity Amaryllidaceae, Lycopodiaceae alkaloids and coumarins obtained from Narcissus triandrus L., Lycopodium clavatum L., Lycopodium annotinum L., Huperzia selago L. and Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. In the in vivo studies. The influence of the tested compounds on the central nervous system of rats was assessed in behavioral tests (locomotor activity, Y-maze, passive avoidance). In order to investigate the mechanisms of action, biochemical determinations were performed (AChE activity, BChE activity, IL-1 beta, IL-6 concentration). In order to assess safety, the concentrations of AST, ALT, GGT and urea and creatinine were determined. The results of the conducted studies indicate a high safety profile of the tested compounds. Behavioral tests showed that they significantly improved rodent memory in a passive avoidance test. The results of biochemical studies showed that by reducing the activity of AChE and BChE and lowering the concentration of IL-1 beta and IL-6, the coumarin-rich Angelica dahurica extract shows the most promising potential for future therapeutic AD strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据