☆ 4.7 Article

Moesin Serves as Scaffold Protein for PD-L1 in Human Uterine Cervical Squamous Carcinoma Cells

JOURNAL OF CLINICAL MEDICINE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Association of PD-L1 and ZEB-1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma

Natsumi Takamaru et al.

Summary: PD-L1 and ZEB-1 are two markers associated with oral squamous cell carcinoma (OSCC). Co-expression of PD-L1 and ZEB-1 is correlated with higher cervical lymph node metastasis and lower survival rate in OSCC patients, indicating their potential as prognostic markers.

ONCOLOGY LETTERS (2022)

添加到收藏夹

Article Biology

PD-L1 Expression Correlated with Clinicopathological Factors and Akt/Stat3 Pathway in Oral SCC

Dong-Ho Geum et al.

Summary: Programmed cell death ligand 1 (PD-L1) plays an important role in the progression of oral squamous cell carcinoma (OSCC) and is closely associated with poor prognosis in patients. Inhibiting PD-L1 expression can lead to increased apoptosis, reduced proliferative capacity, and decreased tumorigenicity in cancer cells.

LIFE-BASEL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pathophysiological Roles of Actin-Binding Scaffold Protein, Ezrin

Kotoku Kawaguchi et al.

Summary: Ezrin, a member of the ezrin/radixin/moesin (ERM) family of proteins, plays key roles in cell migration, survival, signal transduction, and as a structural component. It acts as a cross-linker between membrane proteins or phospholipids and the actin cytoskeleton, as well as a platform for signaling molecules. Consequently, ezrin is an important target in cancer diagnosis and therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Roles of PTEN inactivation and PD-1/PD-L1 activation in esophageal squamous cell carcinoma

Rong Qiu et al.

Summary: This review summarizes the roles of tumor suppressor gene PTEN and programmed cell death protein PD-1 in promoting ESCC, including their involvement in cell proliferation, invasion, migration, and resistance to treatment. The expression of PD-L1 and PTEN is also associated with ESCC progression and patient prognosis.

MOLECULAR BIOLOGY REPORTS (2022)

添加到收藏夹

Article Oncology

UALCAN: An update to the integrated cancer data analysis platform

Darshan Shimoga Chandrashekar et al.

Summary: UALCAN is a web portal for exploring, analyzing, and visualizing cancer genomic, transcriptomic, and proteomic data, providing researchers with valuable insights into gene, protein, and pathway alterations in cancer, as well as evaluating patient survival data.

NEOPLASIA (2022)

添加到收藏夹

Article Medicine, General & Internal

Ezrin Contributes to the Plasma Membrane Expression of PD-L1 in A2780 Cells

Mayuka Tameishi et al.

Summary: Programmed death ligand-1 (PD-L1) is a molecule on the plasma membrane of cancer cells that negatively regulates immune surveillance. This study suggests that ezrin may be responsible for the plasma membrane expression of PD-L1 in ovarian cancer cells, making it a potential therapeutic target for improving immune checkpoint inhibitor treatment.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Medicine, General & Internal

Ezrin Regulates the Cell Surface Localization of PD-L1 in HEC-151 Cells

Chihiro Tanaka et al.

Summary: This study reveals the mechanism of PD-L1 localization on endometrial cancer cell surfaces. The ERM protein family, with Ezrin as a key scaffold protein, contributes to the cell surface localization of PD-L1.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Biology

PD-L1 expression in tongue squamous cell carcinoma

Naoki Akisada et al.

Summary: The study showed a correlation between PD-L1 expression in tongue SCCs and advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors could potentially serve as adjuvant therapy for tongue SCCs with PD-L1 upregulation.

MEDICAL MOLECULAR MORPHOLOGY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Role of Ezrin/Radixin/Moesin in the Surface Localization of Programmed Cell Death Ligand-1 in Human Colon Adenocarcinoma LS180 Cells

Takuro Kobori et al.

Summary: The interaction of PD-L1 with ERM proteins in colorectal adenocarcinoma cells can affect its expression on the cell membrane, thereby potentially modulating the efficacy of PD-1/PD-L1 blockade therapies.

PHARMACEUTICALS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Contribution of Ezrin on the Cell Surface Plasma Membrane Localization of Programmed Cell Death Ligand-1 in Human Choriocarcinoma JEG-3 Cells

Mayuka Tameishi et al.

Summary: The study suggests that ezrin may contribute to the cell surface localization of PD-L1 as a scaffold protein in JEG-3 cells, potentially offering a therapeutic target to improve current ICB therapy in patients with GTN.

PHARMACEUTICALS (2021)

添加到收藏夹

Article Cell Biology

Programmed cell death-ligand 1 expression predicts poor treatment response and prognostic value in esophageal squamous cell carcinoma patients without esophagectomy

Fang Zhang et al.

Aging-US (2021)

添加到收藏夹

Article Oncology

Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases

Camille Faure et al.

Summary: Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2(+) cancer. However, resistance remains a challenge, particularly in the brain metastatic setting. This study identifies a novel class of allosteric HER2 inhibitors, including a compound mimicking Moesin, which effectively inhibits HER2(+) breast tumor progression and shows significant activity on HER2(+) brain tumor progression.

CANCER RESEARCH (2021)

添加到收藏夹

Article Oncology

Phase II study of the safety and efficacy of the anti-PD-1 antibody balstilimab in patients with recurrent and/or metastatic cervical cancer

David M. O'Malley et al.

Summary: This study evaluated the safety and antitumor activity of the anti-PD-1 antibody balstilimab in patients with previously-treated, recurrent/metastatic cervical cancer. Balstilimab demonstrated meaningful clinical activity, with responses seen in both PD-L1 positive and negative tumors, as well as in cervical adenocarcinoma. The most common grade 3 or higher treatment-related adverse events were immune-mediated enterocolitis and diarrhea.

GYNECOLOGIC ONCOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ezrin Modulates the Cell Surface Expression of Programmed Cell Death Ligand-1 in Human Cervical Adenocarcinoma Cells

Chihiro Tanaka et al.

Summary: The ERM family scaffold proteins play a role in PD-L1 expression in HeLa cells, with ezrin potentially acting as a scaffold protein for PD-L1 and regulating its protein expression. This finding suggests ezrin could be a therapeutic target for cervical cancer, improving immune checkpoint blockade therapy.

MOLECULES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Expression and clinical value of PD-L1 which is regulated by BRD4 in tongue squamous cell carcinoma

Lu Zhao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

添加到收藏夹

Review Oncology

Recent Findings in the Posttranslational Modifications of PD-L1

Shu-Man Li et al.

JOURNAL OF ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer

Fanbiao Meng et al.

MOLECULAR ONCOLOGY (2020)

添加到收藏夹

Review Oncology

Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer

Takuo Ogihara et al.

CANCERS (2020)

添加到收藏夹

Review Cell Biology

The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis

Ying-Nai Wang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with tumor characteristics and patient survival

Masaharu Noi et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2020)

添加到收藏夹

Article Oncology

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study

Hyun Cheol Chung et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma

Ying-Hua Xie et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

添加到收藏夹

Article Oncology

Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial

R. Wendel Naumann et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms Controlling PD-L1 Expression in Cancer

Jong-Ho Cha et al.

MOLECULAR CELL (2019)

添加到收藏夹

Review Health Care Sciences & Services

Immunotherapy for Uterine Cervical Cancer

Masahiro Kagabu et al.

HEALTHCARE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells

Xiao-Dan Zhang et al.

NUCLEIC ACIDS RESEARCH (2018)

添加到收藏夹

Article Oncology

Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

Francisco Barbara Abreu Barros et al.

BMC CANCER (2018)

添加到收藏夹

Article Oncology

The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance

Yang-chun Feng et al.

CANCER MANAGEMENT AND RESEARCH (2018)

添加到收藏夹

Article Genetics & Heredity

L1CAM drives oncogenicity in esophageal squamous cell carcinoma by stimulation of ezrin transcription

Jin-Cheng Guo et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

添加到收藏夹

Article Pathology

Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer

Emeka K. Enwere et al.

MODERN PATHOLOGY (2017)

添加到收藏夹

Article Oncology

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

Darshan S. Chandrashekar et al.

NEOPLASIA (2017)

添加到收藏夹

Article Oncology

Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

C. Marth et al.

ANNALS OF ONCOLOGY (2017)

添加到收藏夹

Article Pathology

Programmed death-ligand 1 (PD-L1) is expressed in a significant number of the uterine cervical carcinomas

Opal L. Reddy et al.

DIAGNOSTIC PATHOLOGY (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Pathophysiological Roles of Ezrin/Radixin/Moesin Proteins

Kotoku Kawaguchi et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2017)

添加到收藏夹

Article Oncology

Evaluation of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma

Maria Vassilakopoulou et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹

Review Obstetrics & Gynecology

Changing paradigms in the systemic treatment of advanced cervical cancer

Krista S. Pfaendler et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2016)

添加到收藏夹

Review Oncology

Management of patients with recurrent/advanced cervical cancer beyond first line platinum regimens: Where do we stand? A literature review

Stergios Boussios et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

添加到收藏夹

Review Immunology

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

Jonathan M. Pitt et al.

IMMUNITY (2016)

添加到收藏夹

Article Oncology

Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins

Nagham Asp et al.

ONCOTARGET (2016)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

Expression of ezrin in oral squamous cell carcinoma: Prognostic impact and clinicopathological correlations

Ali-Farid Safi et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2015)

添加到收藏夹

Article Pathology

Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers

Louisa Mezache et al.

MODERN PATHOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma

X. Wang et al.

GENETICS AND MOLECULAR RESEARCH (2014)

添加到收藏夹

Article Cell Biology

ERM proteins in cancer progression

Jarama Clucas et al.

JOURNAL OF CELL SCIENCE (2014)

添加到收藏夹

Article Chemistry, Medicinal

Decreased Radixin Function for ATP-Binding Cassette Transporters in Liver in Adjuvant-Induced Arthritis Rats

Atsushi Kawase et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells

Magdalena Boncler et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2014)

添加到收藏夹

Article Chemistry, Medicinal

Effect of Knockdown of Ezrin, Radixin, and Moesin on P-Glycoprotein Function in HepG2 Cells

Takashi Kano et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

添加到收藏夹

Article Oncology

Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade

Mian He et al.

BMC CANCER (2010)

添加到收藏夹

Review Cell Biology

Organizing the cell cortex: the role of ERM proteins

Richard G. Fehon et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

添加到收藏夹

Article Gastroenterology & Hepatology

Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases

Hideyuki Kojima et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

Heidi Lyng et al.

BMC GENOMICS (2006)

添加到收藏夹

Article Oncology

Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma

H Kobayashi et al.

CLINICAL CANCER RESEARCH (2004)

添加到收藏夹

Article Gastroenterology & Hepatology

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis

H Kojima et al.

JOURNAL OF HEPATOLOGY (2003)

添加到收藏夹

Review Cell Biology

ERM proteins and merlin: Integrators at the cell cortex

A Bretscher et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

添加到收藏夹

Article Genetics & Heredity

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

S Kikuchi et al.

NATURE GENETICS (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.