期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/jcm11144210
关键词
pleomorphic adenoma; epithelial-mesenchymal transition; carcinoma ex-pleomorphic adenoma
资金
- JSPS KAKENHI [JP21K16945]
This article reviews the role of epithelial-mesenchymal transition (EMT) in pleomorphic adenoma (PA) and explores the mechanisms of EMT in the development, chondrocyte differentiation, and malignant transformation of PA.
Pleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30-60 years and is a female predilection; the exact etiology remains unclear. Epithelial-mesenchymal transition (EMT) is the transdifferentiation of stationary epithelial cells primarily activated by a core set of transcription factors (EMT-TFs) involved in DNA repair and offers advantages under various stress conditions. Data have suggested that EMTs represent the basic principle of tissue heterogeneity in PAs, demonstrating the potential of adult epithelial cells to transdifferentiate into mesenchymal cells. It has also been reported that multiple TFs, such as TWIST and SLUG, are involved in EMT in PA and that SLUG could play an essential role in the transition from myoepithelial to mesenchymal cells. Given this background, this review aims to summarize and clarify the involvement of EMT in the development of PA, chondrocyte differentiation, and malignant transformation to contribute to the fundamental elucidation of the mechanisms underlying EMT.
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