Association of Meibomian Gland Dysfunction with Oral Statin Use

Article Medicine, General & Internal

Statin Use Is Associated With a Lower Risk of Blepharitis: A Population-Based Study

Kathy Ming Feng et al.

Summary: Blepharitis is a common eye disorder with symptoms like irritation and itchiness; the use of statins can reduce the risk of developing blepharitis.

FRONTIERS IN MEDICINE (2022)

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Article Ophthalmology

Prevalence and risk factors for dry eye disease: the Sao Paulo dry eye study

Leonardo Guedes C. Marculino et al.

Summary: The study found a higher prevalence of dry eye disease in Sao Paulo city, with women being more affected than men. For women, age and hypertension were significant risk factors for dry eye disease, while eye drops use was an indicator for both sexes.

ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (2022)

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Article Ophthalmology

The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort

Natalia Mussi et al.

Summary: In this study, it was found that risk factors for metabolic syndrome are not specifically associated with an increase in meibomian gland disease (MGD) in a dry eye cohort. However, MGD was associated with male gender and increasing age. While risk factors for metabolic syndrome are related to dry eye disease, they likely reflect a chronic systemic state of low-grade inflammation.

CLINICAL OPHTHALMOLOGY (2021)

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Article Multidisciplinary Sciences

Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea using propensity score matching

Minji Ha et al.

Summary: The study found that patients with meibomian gland dysfunction (MGD) have significantly higher levels of high-density lipoprotein (HDL) and significantly lower levels of low-density lipoprotein (LDL) compared to the general population, although there was no difference in total cholesterol (TC) and triglycerides (TG) levels.

SCIENTIFIC REPORTS (2021)

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Article Ophthalmology

Risk Factors Associated with Meibomian Gland Dysfunction: A Hospital Based Study

Nitin Tulsyan et al.

Summary: The severity of Meibomian Gland Dysfunction increases with age, and there is a significant risk of higher grades of MGD in hypertensive patients, diabetics, and post-menopausal women. Blood sugar, blood pressure, and blood cholesterol levels are seen as risk factors that should be controlled to reduce disease severity.

NEPALESE JOURNAL OF OPHTHALMOLOGY (2021)

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Review Ophthalmology

Dry eye syndrome risk factors: A systemic review

Zahra I. Y. Hasan

Summary: Dry eye disease is a global public health problem with consequences ranging from restrictions in daily life activities to high management costs. There is currently a lack of knowledge regarding the most important risk factors for eye dryness. Female gender, contact lenses, use of computers, thyroid abnormalities, hypertension, antidepressant, and antihistamine have been identified as the strongest and most common risk factors for dry eye syndrome.

SAUDI JOURNAL OF OPHTHALMOLOGY (2021)

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Article Ophthalmology

Association of Dry Eye Disease With Dyslipidemia and Statin Use

Khalid M. Aldaas et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2020)

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Article Ophthalmology

Effect of 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase Inhibitors on the Meibomian Gland Morphology in Patients with Dyslipidemia

Kuan- Wu et al.

AMERICAN JOURNAL OF OPHTHALMOLOGY (2020)

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Article Multidisciplinary Sciences

Clinical efficacy of eyelid hygiene in blepharitis and meibomian gland dysfunction after cataract surgery: a randomized controlled pilot trial

Youngsub Eom et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

Pleiotropic use of Statins as non-lipid-lowering drugs

Qijia Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Ophthalmology

Association of dyslipidaemia and oral statin use, and dry eye disease symptoms in the Blue Mountains Eye Study

Kenneth G. -J. Ooi et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2019)

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Article Ophthalmology

Diabetes mellitus is associated with dry eye syndrome: a meta-analysis

Tae Keun Yoo et al.

INTERNATIONAL OPHTHALMOLOGY (2019)

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Article Ophthalmology

Hyperlipidemia induces meibomian gland dysfunction

Jinghua Bu et al.

OCULAR SURFACE (2019)

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Article Ophthalmology

HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line

Kenneth G-J Ooi et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2019)

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Article Ophthalmology

Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction

Garzon P. Sandra Johanna et al.

JOURNAL OF OPTOMETRY (2019)

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Article Ophthalmology

Association of the severity of meibomian gland dysfunction with dyslipidemia in Indian population

Brahm P. Guliani et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2018)

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Article Ophthalmology

Meibomian glands, meibum, and meibogenesis

Igor A. Butovich

EXPERIMENTAL EYE RESEARCH (2017)

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Review Ophthalmology

TFOS DEWS II pathophysiology report

Anthony J. Bron et al.

OCULAR SURFACE (2017)

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Review Medicine, General & Internal

New onset diabetes mellitus induced by statins: current evidence

Steven G. Chrysant

POSTGRADUATE MEDICINE (2017)

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Article Multidisciplinary Sciences

Asymptomatic Meibomian Gland Dysfunction and Cardiovascular Disease Risk Factors in a MiddleAged Population in Taiwan - A Cross-sectional Analysis

Alexander Chen et al.

SCIENTIFIC REPORTS (2017)

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Review Pharmacology & Pharmacy

PPAR Agonists, Atherogenic Dyslipidemia and Cardiovascular Risk

Dragana Nikolic et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Article Ophthalmology

Dyslipidemia and its association with meibomian gland dysfunction

Puneet S. Braich et al.

INTERNATIONAL OPHTHALMOLOGY (2016)

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Review Ophthalmology

Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics

Xinyuan Zhang et al.

JOURNAL OF OPHTHALMOLOGY (2016)

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Article Ophthalmology

Efficacy and Safety of Topical Atorvastatin for the Treatment of Dry Eye Associated with Blepharitis: A Pilot Study

Kenneth G. -J. Ooi et al.

OPHTHALMIC RESEARCH (2015)

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Review Pharmacology & Pharmacy

The pharmacology of statins

Cesare R. Sirtori

PHARMACOLOGICAL RESEARCH (2014)

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Article Ophthalmology

Psychometric Properties and Validation of the Standard Patient Evaluation of Eye Dryness Questionnaire

William Ngo et al.

CORNEA (2013)

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Article Ophthalmology

Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells

Ying Wang et al.

EXPERIMENTAL EYE RESEARCH (2013)

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Article Ophthalmology

Associations Between the Grade of Meibomian Gland Dysfunction and Dyslipidemia

Amal A. Bukhari

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY (2013)

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Article Ophthalmology

Meibomian Gland Dysfunction and Hypercholesterolemia

Antonio Pinna et al.

OPHTHALMOLOGY (2013)

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Review Nutrition & Dietetics

Dyslipidemia in Obesity: Mechanisms and Potential Targets

Boudewijn Klop et al.

NUTRIENTS (2013)

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Article Ophthalmology

Disruption and Destabilization of Meibomian Lipid Films Caused by Increasing Amounts of Ceramides and Cholesterol

Juan C. Arciniega et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

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Article Medicine, General & Internal

Clinical and Immunological Responses in Ocular Demodecosis

Jae Hoon Kim et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2011)

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Article Ophthalmology