期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/jcm11154632
关键词
meibomian gland dysfunction; dry eye disease; statin; HMG-CoA reductase inhibitor; meiboscore
资金
- National Research Foundation of Korea (NRF) [2022R1A2C2006109]
- National Research Foundation of Korea [2022R1A2C2006109] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study found an association between oral statin use and dry eye disease and meibomian gland dysfunction. Significant differences were observed in total cholesterol, low-density lipoprotein, and meiboscore levels between statin users and nonstatin users. Older age and nonstatin use were associated with higher meiboscores, suggesting a potential protective effect of statins on the meibomian gland.
This retrospective cross-sectional study aimed to determine the association of oral statin use, dry eye disease (DED), and meibomian gland dysfunction (MGD). A total of 93 subjects were included and divided into two groups: statin users (n = 45) and nonstatin users (n = 47). Significant differences were observed in the total cholesterol (p = 0.013), low-density lipoprotein (LDL) (p = 0.005), and meiboscore (p = 0.000) levels between the two groups. For stratified analysis, the statin group was divided into subgroups according to the type or dose of statin and total duration of statin use. However, there were no differences in clinical features between the subgroups. In multiple regression analysis, meiboscore was significantly associated with age (slope = 0.05, p = 0.00) and statin use (slope = -1.19, p = 0.00), with an R-2 of 0.44. Thus, older adults and participants who do not use statin appeared to have higher scores. In conclusion, although the mechanism is unclear, statins may exert a protective effect on the meibomian gland. Further lipidomic studies are required to determine the pharmacological effects of statins on the meibomian gland and other meibum components.
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