3D-PAST: Risk Assessment Model for Predicting Venous Thromboembolism in COVID-19

Article Pharmacology & Pharmacy

Anticoagulant Treatment Regimens in Patients with Covid-19: A Meta-Analysis

Anselm Jorda et al.

Summary: In patients with COVID-19, higher-dose anticoagulation compared to prophylactic-dose anticoagulation reduces the risk of thromboembolic events but increases the risk of major bleeding, with no significant impact on the risk of death.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Cardiac & Cardiovascular Systems

Incidence, Mortality, and Imaging Outcomes of Atrial Arrhythmias in COVID-19

Qasim Jehangir et al.

Summary: Atrial arrhythmias (AAs) are associated with poor clinical outcomes in hospitalized patients with COVID-19, including in-hospital mortality rate and incidence of new-onset congestive heart failure.

AMERICAN JOURNAL OF CARDIOLOGY (2022)

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Article Immunology

Venous Thromboembolism and Major Bleeding in Patients With Coronavirus Disease 2019 (COVID-19): A Nationwide, Population-Based Cohort Study

Michael Dalager-Pedersen et al.

Summary: In a population-based setting, the risk of VTE among individuals with SARS-CoV-2 infection is low to moderate and not significantly increased compared to SARS-CoV-2 test-negative and influenza patients. However, ICU patients may face a higher risk of bleeding while receiving thromboprophylaxis.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Respiratory System

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

Joan Loo et al.

Summary: Thrombotic events in COVID-19, especially venous thromboemboli, are associated with disease severity and poor clinical outcomes. Distinctive microvascular abnormalities include endothelial inflammation, disruption of intercellular junctions, and microthrombi formation. COVID-19 can lead to immunothrombosis, and a better understanding of the pathobiological mechanisms is crucial for developing new treatments.

THORAX (2021)

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Letter Hematology

Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report

Francesco Violi et al.

THROMBOSIS AND HAEMOSTASIS (2021)

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Review Critical Care Medicine

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

David Jimenez et al.

Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.

CHEST (2021)

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Article Medicine, General & Internal

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

Christopher T. Rentsch et al.

Summary: The study found that early initiation of prophylactic anticoagulation was associated with decreased risk of 30 day mortality among patients hospitalized with covid-19 in the United States, without increasing the risk of serious bleeding events.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Hematology

American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19

Adam Cuker et al.

Summary: The American Society of Hematology provided two conditional recommendations for anticoagulation in COVID-19-related critical illness and acute illness, emphasizing the low certainty in the evidence and the importance of future high-quality randomized controlled trials for validation.

BLOOD ADVANCES (2021)

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Article Hematology

Bleeding risk by intensity of anticoagulation in critically ill patients with COVID-19: A retrospective cohort study

Rim Halaby et al.

Summary: Critically ill patients with COVID-19 had a similar risk of bleeding as those with other respiratory viral illnesses. Therapeutic-intensity anticoagulation was associated with a higher risk of major bleeding compared to standard thromboprophylaxis when accounting for changes in anticoagulation intensity.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems

SOFA Score as a Reliable Tool to Detect High Risk for Venous Thrombosis in Patients With Critical Stage SARS-CoV-2

Giorgio Prouse et al.

Summary: For critically ill SARS-CoV-2 patients, those with a SOFA score of 1 or 2 are at low risk of developing DVT and do not require therapeutic-intensity anticoagulation, while patients with scores >= 3 are at high risk of developing DVT.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19

Matthew Kheir et al.

Summary: Admission serum albumin levels appear to be a predictive biomarker for outcomes in COVID-19 patients. Higher albumin levels on admission were associated with significantly fewer adverse outcomes, including less VTE events, ARDS development, ICU admissions, and readmissions within 90 days. Screening patients based on albumin levels may help identify those at risk for complications and improve preventative efforts.

PLOS ONE (2021)

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Review Peripheral Vascular Disease

Venous thromboembolism in COVID-19: A systematic review and meta-analysis

Anastasios Kollias et al.

Summary: Severe COVID-19 is associated with an increased risk of VTE, with higher prevalence in patients with higher D-dimer levels and a higher percentage of ICU patients. The pooled odds ratio for death in COVID-19 patients with VTE versus those without VTE was 2.1, indicating a higher mortality risk. Preventive anticoagulation therapy should be investigated further for individualized VTE risk assessment in COVID-19 patients.

VASCULAR MEDICINE (2021)

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Article Surgery

The original and modified Caprini score equally predicts venous thromboembolism in COVID-19 patients

Sergey Tsaplin et al.

Summary: This study confirmed a significant correlation between the Caprini score and VTE risk in patients with COVID-19. All models incorporating specific COVID-19 scores showed equally high predictability, with the original Caprini score being appropriate for patients with COVID-19.

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS (2021)

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Article Hematology

Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study

Jana J. Anderson et al.

Summary: The study explored the association between remote history of VTE and COVID-19 severity, finding that a remote history of VTE is associated with an increased risk of nonfatal community, nonfatal hospitalized, and severe COVID-19. The association was stronger among men, suggesting the importance of considering sex-specific risk factors in COVID-19 risk prediction models.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

The CoVID-TE risk assessment model for venous thromboembolism in hospitalized patients with cancer and COVID-19

Ang Li et al.

Summary: Hospitalized patients with cancer and COVID-19 are at increased risk of VTE and ATE. A simplified RAM model named CoVID-TE was developed to predict VTE in this vulnerable population, showing good performance in stratifying patients into low-risk and high-risk cohorts based on clinical risk factors. The CoVID-TE RAM may aid in real-time data-driven decisions for thrombosis prevention in this population.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems

External validation of the IMPROVE-DD risk assessment model for venous thromboembolism among inpatients with COVID-19

Mark Goldin et al.

Summary: The IMPROVE-DD VTE RAM demonstrated good discrimination in identifying low, moderate, and high VTE risk in hospitalized COVID-19 patients, with a sensitivity of 0.971, specificity of 0.215, PPV of 0.036, and NPV of 0.996. The ROC AUC was 0.703, indicating very good discrimination ability in an external validation study.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Patrick R. Lawler et al.

Summary: This study showed that therapeutic-dose anticoagulation with heparin in non-critically ill patients with Covid-19 increased the likelihood of survival to hospital discharge and reduced the need for cardiovascular or respiratory organ support compared to usual-care thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Trends in Venous Thromboembolism Anticoagulation in Patients Hospitalized With COVID-19

Valerie M. Vaughn et al.

Summary: This study analyzed a large, multicenter cohort of patients hospitalized with COVID-19 and found that only a small number of patients had confirmed VTE, with varying use of treatment-dose anticoagulation across hospitals. Nonadherence to VTE prevention and anticoagulation strategies were associated with 60-day mortality, while receiving any dose of anticoagulation (compared to no anticoagulation) was associated with lower in-hospital mortality.

JAMA NETWORK OPEN (2021)

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Article Hematology

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients

Adam Cuker et al.

Summary: The American Society of Hematology (ASH) guidelines recommend prophylactic-intensity anticoagulation over intermediate-intensity anticoagulation in critically ill patients with COVID-19 who do not have confirmed or suspected VTE. The recommendation was based on low certainty evidence, highlighting the need for more high-quality randomized controlled trials to compare different intensities of anticoagulation in critically ill patients. Other key research priorities include better evidence on predictors of thrombosis and bleeding risk in critically ill patients with COVID-19, as well as the impact of nonanticoagulant therapies on thrombotic risk.

BLOOD ADVANCES (2021)

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Article Hematology

Anticoagulation and In-Hospital Mortality From Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

Chatphatai Moonla et al.

Summary: Coagulation abnormalities in COVID-19 patients can worsen disease severity, but the efficacy varies among different doses of anticoagulation therapy. Prophylactic dose anticoagulation shows lower mortality risk compared to non-anticoagulated patients, while intermediate-to-therapeutic dose anticoagulation may increase mortality and major bleeding. Our findings support the use of prophylactic dose anticoagulation for optimal efficacy and safety in hospitalized COVID-19 patients.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Hematology

Validation of the IMPROVE-DD risk assessment model for venous thromboembolism among hospitalized patients with COVID-19

Alex C. Spyropoulos et al.

Summary: The external validation study of the IMPROVE-DD VTE RAM showed good discrimination in identifying low, moderate, and high VTE risk in hospitalized patients with COVID-19, indicating its potential to individualize thromboprophylactic strategies.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

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Article Respiratory System

Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19

Mingshan Xue et al.

Summary: The study found that in critically ill COVID-19 patients, HBP levels are closely related to disease progression and pulmonary ventilation-perfusion status. Elevated HBP levels up to 5 days before clinical deterioration may predict worsening of patient condition.

ERJ OPEN RESEARCH (2021)

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Letter Cardiac & Cardiovascular Systems

Pulmonary Embolism in Patients With COVID-19 Awareness of an Increased Prevalence

Julien Poissy et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Serum Albumin Is a Marker of Myocardial Fibrosis, Adverse Pulsatile Aortic Hemodynamics, and Prognosis in Heart Failure With Preserved Ejection Fraction

Stuart B. Prenner et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Letter Hematology

Heparin - An old drug with multiple potential targets in Covid-19 therapy

Ulf Lindahl et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19

Alex C. Spyropoulos et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Cardiac & Cardiovascular Systems

Heparin resistance in COVID-19 patients in the intensive care unit

D. White et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Critical Care Medicine

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

Sharon E. Fox et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Critical Care Medicine

Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019 CHEST Guideline and Expert Panel Report

Lisa K. Moores et al.

CHEST (2020)

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Article Hematology

Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience

Ahmad Hanif et al.

ANNALS OF HEMATOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Rate of venous thromboembolism in a prospective all-comers cohort with COVID-19

Marina Rieder et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Infectious Diseases

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

Luca Carsana et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Hematology

Anticoagulation and bleeding risk in patients with COVID-19

Nancy Musoke et al.

THROMBOSIS RESEARCH (2020)

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Review Medicine, General & Internal

Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis

Mahmoud B. Malas et al.

ECLINICALMEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Predicting Venous Thromboembolic Events in Patients with Coronavirus Disease 2019 Requiring Hospitalization: an Observational Retrospective Study by the COVIDIC Initiative in a Swiss University Hospital

Eleftheria Kampouri et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Medicine, General & Internal

Heparin-binding protein: a key player in the pathophysiology of organ dysfunction in sepsis

J. Fisher et al.

JOURNAL OF INTERNAL MEDICINE (2017)

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Article Emergency Medicine

D-dimer Interval Likelihood Ratios for Pulmonary Embolism

Michael A. Kohn et al.

ACADEMIC EMERGENCY MEDICINE (2017)

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Article Emergency Medicine

Blood pressure for outcome prediction and risk stratification in acute pulmonary embolism

Karsten Keller et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2015)

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Article Critical Care Medicine

VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock

David Kaplan et al.

CHEST (2015)

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Article Critical Care Medicine

Predictive and Associative Models to Identify Hospitalized Medical Patients at Risk for VTE

Alex C. Spyropoulos et al.

CHEST (2011)

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Article Hematology

A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score

S. Barbar et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

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Article Hematology

Serum albumin and risk of venous thromboembolism

Aaron R. Folsom et al.

THROMBOSIS AND HAEMOSTASIS (2010)

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Article Immunology

Coronaviridae and SARS-associated coronavirus strain HSR1

E Vicenzi et al.

EMERGING INFECTIOUS DISEASES (2004)

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Article Hematology

Use of different D-dimer levels to exclude venous thromboembolism depending on clinical pretest probability

LA Linkins et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)

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Article Emergency Medicine

Prospective validation of wells criteria in the evaluation of patients with suspected pulmonary embolism

SJ Wolf et al.

ANNALS OF EMERGENCY MEDICINE (2004)

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Review Cardiac & Cardiovascular Systems

Acute pulmonary embolism: Part I - Epidemiology, pathophysiology, and diagnosis

SZ Goldhaber et al.

CIRCULATION (2003)

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Article Medicine, General & Internal

Excluding pulmonary embolism at the bedside without diagnostic imaging: Management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer

PS Wells et al.

ANNALS OF INTERNAL MEDICINE (2001)

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3D-PAST: Risk Assessment Model for Predicting Venous Thromboembolism in COVID-19

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