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Xiaoyun Deng et al.
CHEMMEDCHEM (2019)
Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors
Nan He et al.
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Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease
E. P. Lebois et al.
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Wessel A. C. Burger et al.
JOURNAL OF GENERAL PHYSIOLOGY (2018)
Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia
Michael R. Wood et al.
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Beatrice Mihaela Radu et al.
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Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
James C. Tarr et al.
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Touqeer Ahmed et al.
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Michael R. Wood et al.
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Cecilie de la Cour et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Wesley K. Kroeze et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
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Michael Bubser et al.
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Yuji Odagaki et al.
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P. Jeffrey Conn et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Muscarinic acetylcholine receptors: novel opportunities for drug development
Andrew C. Kruse et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Uyen Le et al.
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Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
James M. Salovich et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor
S. Suratman et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice
Lene S. Schmidt et al.
PSYCHOPHARMACOLOGY (2011)
Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties
Katie Leach et al.
NEUROPSYCHOPHARMACOLOGY (2010)
Synthesis and Structure-Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor
J. Phillip Kennedy et al.
CHEMMEDCHEM (2009)
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
P. Jeffrey Conn et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
Anantha Shekhar et al.
AMERICAN JOURNAL OF PSYCHIATRY (2008)
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Ashley E. Brady et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
W. Y. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
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Jana K. Shirey et al.
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Towards a muscarinic hypothesis of schizophrenia
T. J. Raedler et al.
MOLECULAR PSYCHIATRY (2007)
Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients
E Mulugeta et al.
BRAIN RESEARCH (2003)
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