期刊
EBIOMEDICINE
卷 82, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2022.104124
关键词
Multiple sclerosis; Diet; Intermittent fasting; Immunophenotyping
资金
- National MS Society
- NIH
- Johns Hopkins Catalyst Award
In people with multiple sclerosis, an intermittent calorie restriction diet is associated with reduction in memory T cell subsets and changes in certain lipid markers.
Background Intermittent fasting or calorie restriction (CR) diets provide anti-inflammatory and neuroprotective advantages in models of multiple sclerosis (MS); data in humans are sparse. Methods We conducted a randomised-controlled feeding study of different CR diets in 36 people with MS over 8 weeks. Participants were randomised to 1 of 3 diets: 1) a control diet, in which the participant received 100% of his or her calorie needs 7 days per week, 2) a daily CR diet, in which the participant received 78% of his or her calorie needs 7 days per week, or 3) an intermittent CR diet, in which the participant received 100% of his or her calorie needs on 5 days per week and 25% of his or her calorie needs 2 days per week (i.e., a 5:2 style diet). Untargeted metabolomics was performed on plasma samples at weeks 0, 4 and 8 at Metabolon Inc (Durham, NC). Flow cytometry of cryopreserved peripheral blood mononuclear cells at weeks 0 and 8 were used to identify CD3(+);CD4(+) (CD4(+)) and CD3(+); CD4(-) (as a proxy for CD8(+)) T cell subsets including effector memory, central memory, and naive cells. Findings 31 (86%) completed the trial. Over time, individuals randomised to intermittent CR had significant reductions in effector memory (for CD4(-) EM:-3.82%; 95%CI:-7.44,-0.21; for CD4(-) :-6.96%; 95%CI:-11.96,-1.97) and Th1 subsets (-4.26%; 95% CI:-7.11,-1.40) and proportional increases in naive subsets (for CD4(-) : 10.11%; 95%CI: 3.30, 16.92%). No changes were observed for daily CR or weight-stable diets. Larger within-person changes in lysophospholipid and lysoplasmalogen metabolites in intermittent CR were associated with larger reductions in memory T cell subsets and larger increases in naive T cell subsets. Interpretation In people with MS, an intermittent CR diet was associated with reduction in memory T cell subsets and certain biologically-relevant lipid markers. Copyright (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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