4.7 Article

Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity

期刊

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/jitc-2022-005065

关键词

Immunotherapy; Tumor Microenvironment; Programmed Cell Death 1 Receptor; Oncolytic Virotherapy; Drug Therapy; Combination

资金

  1. Zhejiang Provincial College Student Science and Technology Innovation Activity Plan-College Student Innovation and Entrepreneurship Incubation Program (Young Talent Program) [2022R40122]
  2. National Natural Science Foundation of China [31970696, 81502975, 82188102]
  3. Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar [LR22H160010]
  4. National Key Research and Development Program of China [2019YFC1316000]

向作者/读者索取更多资源

Oncolytic peptides are highly effective in remodeling the tumor microenvironment and enhancing anticancer immunity by inducing immunogenic cell death. A recent study shows that LTX-315 inhibits PD-L1 expression via ATP11B, thereby enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. This commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, as well as the potential issues and directions in cancer immunotherapy.
Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy.

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