期刊
SCIENCE ADVANCES
卷 8, 期 26, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abo2896
关键词
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资金
- Wenner-Gren Foundation
- Foundation Blanceflor Boncompagni Ludovisi, nee Bildt
- Tore Nilsson Foundation for Medical Science
- National Institutes of Health (NIH) [AG053592, DK114652]
- Novo Nordisk Foundation Challenge Grant
- Institut National de la Sante et la Recherche Medicale [U1233]
- European Research Council (ERC) under the European Union [787041]
- Government of Cataluna (SGR grant)
- Government of Spain (MINECO)
- La Marato/TV3 Foundation
- Foundation Lilliane Bettencourt
- Spanish Association for Cancer Research (AECC)
- Worldwide Cancer Research Foundation (WCRF)
- IRB Barcelona is a Severo Ochoa Center of Excellence [SEV-2015-0505]
- AFM, DPP-Spain [MICINN-RTI2018-096068, ERC-2016-AdG-741966, LaCaixa-HEALTH-HR17-00040, UPGRADE-H2020-825825]
- Fundacio La Marato [TV3-80/19-202021]
- MWRF
- Maria-de-Maeztu Program for Units of Excellence [2014-0370]
- Japan Society for the Promotion of Science (JSPS) fellowship
- European Union [749869, 754510]
- MCIN/AEI/ [RYC2019-026661-I]
- ESF Investing in your future
- NIH [GM117942, NIH GM123558]
- American Heart Association [17PRE33410952]
- UCI School of Medicine Behrens Research Excellence Award
- European Research Council (ERC) [787041] Funding Source: European Research Council (ERC)
- Marie Curie Actions (MSCA) [749869] Funding Source: Marie Curie Actions (MSCA)
Life on Earth relies on molecular clocks and intertissue communication to regulate circadian and metabolic rhythms, with the central clock playing a crucial role in governing metabolic rhythms.
Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals.
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