期刊
CHEM
卷 8, 期 9, 页码 2498-2513出版社
CELL PRESS
DOI: 10.1016/j.chempr.2022.06.006
关键词
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资金
- National Natural Science Foundation of China [21725501, 21874007]
- Beijing Municipal Natural Science Foundation [2212011]
- Royal Society
- Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University [2020ZD01]
In this study, a nanoplatform consisting of CMC NFs and F-19 probes has been developed, which can enhance therapeutic efficiency and activate F-19 MRI capability within the tumor microenvironment. The nanoplatforms can effectively disrupt redox homeostasis and perform tumor-specific chemodynamic therapy, offering great potential for deep-seated tumor diagnosis and treatment.
Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and F-19 probes have been developed, which exhibit enhanced therapeutic efficiency and activatable F-19 magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cu-ox/Cu-red, Mn-ox/Mn-red) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the F-19 MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable (FMRI)-F-19-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.
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