Recent Advances in the Synthesis of 5-Membered N-Heterocycles via Rhodium Catalysed Cascade Reactions

Five membered N-heterocycles are significant targets in organic synthesis because of their ubiquitous existence in bioactive natural products and pharmaceuticals. Over the past decade a compelling attractiveness has grown to develop rhodium complex catalysed efficient and atom-economic chemistry to access structurally diverse N-heterocyclic frameworks. This present review enlightens notable progresses and advances in synthesis of 5-membered N-heterocycles via rhodium catalysed cascade reactions (annulations, C-H/C-C activation, cycloaddition, rearrangement, cyclization, metathesis) from 2018-2021.

Automated summary

This review summarizes the significant progress and advances in the synthesis of 5-membered N-heterocycles through rhodium-catalyzed cascade reactions, including annulations, C-H/C-C activation, cycloaddition, rearrangement, cyclization, and metathesis, from 2018 to 2021.