期刊
ADVANCED FUNCTIONAL MATERIALS
卷 25, 期 12, 页码 1822-1831出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201404372
关键词
DNA; electron transfer; iron oxide nanoparticles; metamaterials; nanoconjugates
类别
资金
- Italian Institutional Ministry [60A06-7411, 60A06-8055]
- CARIPARO (Cassa Risparmio di Padova e Rovigo) foundation
- Operational Program Research and Development for Innovations - European Regional Development Fund [CZ.1.05/2.1.00/03.0058]
- Operational Program Education for Competitiveness - European Social Fund of the Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.07/2.3.00/20.0155]
- Grant Agency of the Academy of Sciences of the Czech Republic [KAN115600801, KAN200380801]
A new category of iron oxide nanoparticles (surface active maghemite nanoparticles (SAMNs, -Fe2O3)) allows the intimate chemical and electrical contact with DNA by direct covalent binding. On these basis, different DNA-nanoparticle architectures are developed and used as platform for studying electrical properties of DNA. The macroscopic 3D nanobioconjugate, constituted of 5% SAMNs, 70% water, and 25% DNA, shows high stability, electrochemical reversibility and, moreover, electrical conductivity (70-80 cm(-1)). Reversible electron transfer at the interface between nanoparticles and DNA is unequivocally demonstrated by Mossbauer spectroscopy, which shows the appearance of Fe(II) atoms on nanoparticles following nanobioconjugate formation. This represents the first example of permanent electron exchange by DNA, as well as, of DNA conductivity at a macroscopic scale. Finally, the most probable configuration of the binding is tentatively modeled by density functional theory (DFT/UBP86/6-31+G*), showing the occurrence of electron transfer from the organic orbitals of DNA to surface exposed Fe(III) on nanoparticles, as well as the generation of defects (holes) on the DNA bases. The unequivocal demonstration of DNA conduction provides a new perspective in the five decades long debate about electrical properties of this biopolymer, further suggesting novel approaches for DNA exploitation in nanoelectronics.
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