期刊
FRONTIERS IN PSYCHIATRY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2022.967941
关键词
spectroscopy; NMDA; imaging and schizophrenia; CSF-correction; longitudinal; glutamate
类别
资金
- Medical Research Council-UK
- Maudsley Charity [MC_U120097115]
- Wellcome Trust [666]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London [094849/Z/10/Z]
- Lord Leverhulme Charitable Trust
- UCL Welcome Ph.D. Fellowship
- UCL [102186/B/13/Z]
- Max Planck Society
This study found that baseline glutamatergic levels are unlikely to predict treatment response in patients with first episode psychosis. Antipsychotic treatment also does not significantly affect glutamate levels in the anterior cingulate cortex.
IntroductionGlutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP). Materials and methodsThe sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). ResultsThere was no significant change in glutamate [baseline 13.23 +/- 2.33; follow-up 13.89 +/- 1.74; t(21) = -1.158, p = 0.260], or Glx levels [baseline 19.64 +/- 3.26; follow-up 19.66 +/- 2.65; t(21) = -0.034, p = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu r = 0.061, p = 0.777, Glx r = -0.152, p = 0.477), negative (Glu r = 0.144, p = 0.502, Glx r = 0.052, p = 0.811), general (Glu r = 0.110, p = 0.607, Glx r = -0.212, p = 0.320), or total scores (Glu r = 0.078, p = 0.719 Glx r = -0.155, p = 0.470). ConclusionThese findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC.
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