期刊
JOURNAL OF ENVIRONMENTAL QUALITY
卷 45, 期 2, 页码 394-406出版社
WILEY
DOI: 10.2134/jeq2015.07.0336
关键词
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资金
- Agriculture and Food Research Initiative Competitive from USDA National Institute of Food and Agriculture [2013-68003-21256]
- National Pork Board (Iowa, USA)
- NIFA [577212, 2013-68003-21256] Funding Source: Federal RePORTER
We propose a simple causal model depicting relationships involved in dissemination of antibiotics and antibiotic resistance in agroecosystems and potential effects on human health, functioning of natural ecosystems, and agricultural productivity. Available evidence for each causal link is briefly summarized, and key knowledge gaps are highlighted. A lack of quantitative estimates of human exposure to environmental bacteria, in general, and antibiotic-resistant bacteria, specifically, is a significant data gap hindering the assessment of effects on human health. The contribution of horizontal gene transfer to resistance in the environment and conditions that might foster the horizontal transfer of antibiotic resistance genes into human pathogens also need further research. Existing research has focused heavily on human health effects, with relatively little known about the effects of antibiotics and antibiotic resistance on natural and agricultural ecosystems. The proposed causal model is used to elucidate gaps in knowledge that must be addressed by the research community and may provide a useful starting point for the design and analysis of future research efforts.
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